Publications by authors named "Prachi P Agarwal"

Article Synopsis
  • - Of the 5 randomized controlled trials (RCTs) analyzed, 20% of participants had chronic thromboembolic pulmonary hypertension (CTEPH), but none specifically studied the impacts of exercise training in these patients.
  • - The study suggests that exercise training can enhance exercise capacity in pulmonary hypertension (PH) patients, specifically indicated by improvements in 6-minute walk distance.
  • - It also highlights that exercise training appears to be safe for patients with CTEPH and pulmonary arterial hypertension (PAH), challenging the common belief that exercise is risky for these individuals.
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  • Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension (CTEPH) faces challenges due to the need for safe devices to cross vascular lesions, prompting a study on the piercing properties of artery walls and CTEPH lesions.
  • In a lab experiment using specimens from nine patients, researchers measured the force required to penetrate artery walls and CTEPH lesions, finding that less force was needed for lesions compared to the arterial wall.
  • The study concluded that the arterial wall is delicate and can be damaged easily, but the lower force needed to cross CTEPH lesions suggests a potential safety margin for improving balloon pulmonary angioplasty procedures.
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  • Catheter-based treatments are becoming important for both acute and chronic pulmonary blood clots, making it essential to understand the anatomy of pulmonary arterial branches.* -
  • A study of 179 patients undergoing angiography showed a variety of branching patterns in the pulmonary arteries, with a total of 7 patterns in the right upper lobe, 3 in the right middle lobe, and so on across the left lobes.* -
  • Notably, only 2-3 branching patterns per lobe were responsible for over 90% of the observed variations, offering valuable insights for medical professionals and future research in pulmonary interventions.*
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This document summarizes the relevant literature for the selection of preprocedural imaging in three clinical scenarios in patients needing endovascular treatment or cardioversion of atrial fibrillation. These clinical scenarios include preprocedural imaging prior to radiofrequency ablation; prior to left atrial appendage occlusion; and prior to cardioversion. The appropriateness of imaging modalities as they apply to each clinical scenario is rated as usually appropriate, may be appropriate, and usually not appropriate to assist the selection of the most appropriate imaging modality in the corresponding clinical scenarios.

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Unroofed sinus is categorized into four subtypes. Types I and II represent complete unroofing with or without an LSVC, respectively [1]. Types III and IV are partial unroofing involving the mid-CS (type III) or near the LA appendage and left superior pulmonary vein (type IV) [1].

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In this review, the authors summarize the role of coronary computed tomography angiography and coronary artery calcium scoring in different clinical presentations of chest pain and preventative care and discuss future directions and new technologies such as pericoronary fat inflammation and the growing footprint of artificial intelligence in cardiovascular medicine.

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  • * While initially thought to primarily affect the right ventricle, ACM can also impact the left ventricle or both ventricles, leading to changes in diagnostic criteria due to evolving understanding of the disease.
  • * The updated Padua criteria enhance diagnosis by including modern imaging techniques like cardiac MRI and recognizing features such as ventricular dilation and tissue characterization, while considering other conditions that could mimic ACM, especially in right-dominant and left-dominant phenotypes.
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Tuberculosis (TB) afflicted 10.6 million people in 2021, and its global burden is increasing due to multidrug-resistant TB (MDR-TB) and extensively resistant TB (XDR-TB). Here, we analyze multi-domain information from 5,060 TB patients spanning 10 countries with high burden of MDR-TB from the NIAID TB Portals database to determine predictors of TB treatment outcome.

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  • Accurately diagnosing severe COVID-19 lung infections is critical for timely oxygen treatment and hospitalization, as severe cases pose higher health risks and may lead to lasting lung damage requiring follow-up imaging.
  • Researchers developed deep learning neural network models using chest radiographs (CXR) to differentiate between severe and non-severe COVID-19 lung infections, utilizing a dataset of 5748 cases and 6193 images from various countries and institutions.
  • The performance of the models was assessed using an area under the receiver operating characteristic curve (AUC), with the Inception-v4 models achieving higher accuracy (AUC of 0.85-0.89) compared to the Inception-v1 models (AUC of 0.
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Background: Tetralogy of Fallot (ToF) is the most common form of cyanotic congenital heart disease, where right ventricular (RV) function is an important determinant of subsequent intervention.

Objective: In this study, we evaluate the feasibility of fast strain-encoding (fastSENC; a one-heartbeat sequence) magnetic resonance imaging (MRI) for assessing regional cardiac function in ToF.

Method: FastSENC was implemented to characterize regional circumferential (Ecc) and longitudinal (Ell) strains in the left ventricle (LV) and RV in post-repair ToF.

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Noncerebral systemic arterial embolism, which can originate from cardiac and noncardiac sources, is an important cause of patient morbidity and mortality. When an embolic source dislodges, the resulting embolus can occlude a variety of peripheral and visceral arteries causing ischemia. Characteristic locations for noncerebral arterial occlusion include the upper extremities, abdominal viscera, and lower extremities.

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Background: Balloon pulmonary angioplasty (BPA) was introduced as a treatment modality for patients with inoperable, medically refractory chronic thromboembolic pulmonary hypertension decades ago; however, reports of high rates of pulmonary vascular injury have led to considerable refinement in procedural technique.

Objectives: The authors sought to better understand the evolution of BPA procedure-related complications over time.

Methods: The authors conducted a systematic review of original articles published by pulmonary hypertension centers globally and performed a pooled cohort analysis of procedure-related outcomes with BPA.

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Background: Frequent premature ventricular complexes (PVCs) can result in a reversible form of cardiomyopathy that usually affects the left ventricle (LV).

Objectives: The objective of this study was to assess whether frequent PVCs have an impact on right ventricular (RV) function.

Methods: Serial cardiac magnetic resonance (CMR) studies were performed in a series of 47 patients before and after ablation of frequent PVCs.

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Background: Balloon pulmonary angioplasty (BPA) is currently performed at select centers worldwide, with the current standard of practice being postprocedural inpatient monitoring for 24 to 72 hours. We sought to evaluate the safety and efficacy of BPA in a cohort of patients with chronic thrombo-embolic pulmonary disease (CTEPD) and chronic thromboembolic pulmonary hypertension (CTEPH) and outline a protocol for implementation in the outpatient setting.

Methods: All patients with distal, inoperable CTEPH, residual symptoms after pulmonary endarterectomy, or symptomatic CTEPD from July 1, 2020, to June 30, 2022, were evaluated by a multidisciplinary chronic thromboembolic pulmonary hypertension team for consideration of BPA.

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Balloon pulmonary angioplasty (BPA) is an evolving treatment modality for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not candidates for pulmonary endarterectomy. Although several imaging modalities currently exist for evaluating CTEPH, their individual use, specifically in the clinical practice of BPA, has not been well described. In this article, we provide a preprocedural, intraprocedural, and postprocedural interventional imaging roadmap for safe and effective BPA performance in routine clinical practice.

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Myocardial strain is a measure of myocardial deformation, which is a more sensitive imaging biomarker of myocardial disease than the commonly used ventricular ejection fraction. Although myocardial strain is commonly evaluated by using speckle-tracking echocardiography, cardiovascular MRI (CMR) is increasingly performed for this purpose. The most common CMR technique is feature tracking (FT), which involves postprocessing of routinely acquired cine MR images.

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Management of patients with chronic chest pain in the setting of high probability of coronary artery disease (CAD) relies heavily on imaging for determining or excluding presence and severity of myocardial ischemia, hibernation, scarring, and/or the presence, site, and severity of obstructive coronary lesions, as well as course of management and long-term prognosis. In patients with no known ischemic heart disease, imaging is valuable in determining and documenting the presence, extent, and severity of obstructive coronary narrowing and presence of myocardial ischemia. In patients with known ischemic heart disease, imaging findings are important in determining the management of patients with chronic myocardial ischemia and can serve as a decision-making tool for medical therapy, angioplasty, stenting, or surgery.

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Tracheobronchomalacia (TBM) and excessive dynamic airway collapse (EDAC) are airway abnormalities that share a common feature of expiratory narrowing but are distinct pathophysiologic entities. Both entities are collectively referred to as expiratory central airway collapse (ECAC). The or weakness of cartilage that supports the tracheobronchial tree may occur only in the trachea (ie, tracheomalacia), in both the trachea and bronchi (TBM), or only in the bronchi (bronchomalacia).

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Lymphatic abnormalities encompass a wide range of disorders spanning solitary common cystic lymphatic malformations (LMs) to entities involving multiple organ systems such as lymphangioleiomyomatosis. Many of these disorders are rare, yet some, such as secondary lymphedema from the treatment of malignancy (radiation therapy and/or lymph node dissection), affect millions of patients worldwide. Owing to complex and variable anatomy, the lymphatics are not as well understood as other organ systems.

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Medical errors may lead to patient harm and may also have a devastating effect on medical providers, who may suffer from guilt and the personal impact of a given error (second victim experience). While it is important to recognize and remedy errors, it should be done in a way that leads to long-standing practice improvement and focuses on systems-level opportunities rather than in a punitive fashion. Traditional peer review systems are score based and have some undesirable attributes.

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