The 2024 British Society for Rheumatology guideline for management of systemic sclerosis.

This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare professionals with expertise in SSc and people with lived experience, as well as patient organization representatives. It is an update of the previous 2015 SSc guideline. The recommendations were developed and agreed by the group and are underpinned by published evidence, assessed by systematic literature review and reinforced by collective expert opinion of the group.

The 2024 British Society for Rheumatology guideline for management of systemic sclerosis-executive summary.

This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare professionals with expertise in SSc and people with lived experience, as well as patient organization representatives. It is an update of the previous 2015 SSc guideline. The recommendations were developed and agreed by the group and are underpinned by published evidence, assessed by systematic literature review and reinforced by collective expert opinion of the group.

Electrospun PVDF/aromatic HBP of 4th gen based flexible and self-powered TENG for wearable energy harvesting and health monitoring.

In recent times, high-performance wearable electronic devices that can transform mechanical force into electrical energy for biomedical monitoring applications are receiving an increasing amount of attention. In the present study, we focused on a flexible, self-powered and wearable triboelectric nanogenerator (TENG) based on electrospun polyvinylidene fluoride (PVDF)/aromatic hyperbranched polyester of 4th generation (Ar.HBP-G4, 0-40 wt.

Enzymatic and biochemical properties of lens in age-related cataract versus diabetic cataract: A narrative review.

Cataract is the leading cause of blindness worldwide. There is an increased incidence of cataract formation in the diabetic population due to several factors. Diabetes mellitus accelerates the development of cataract.

A Comprehensive Review on Processing, Development and Applications of Organofunctional Silanes and Silane-Based Hyperbranched Polymers.

Since the last decade, hyperbranched polymers (HBPs) have gained wider theoretical interest and practical applications in sensor technology due to their ease of synthesis, highly branched structure but dimensions within nanoscale, a larger number of modified terminal groups and lowering of viscosity in polymer blends even at higher HBP concentrations. Many researchers have reported the synthesis of HBPs using different organic-based core-shell moieties. Interestingly, silanes, as organic-inorganic hybrid modifiers of HBP, are of great interest as they resulted in a tremendous improvement in HBP properties like increasing thermal, mechanical and electrical properties compared to that of organic-only moieties.

Fabrication of CuO-NP-Doped PVDF Composites Based Electrospun Triboelectric Nanogenerators for Wearable and Biomedical Applications.

A flexible and portable triboelectric nanogenerator (TENG) based on electrospun polyvinylidene fluoride (PVDF) doped with copper oxide (CuO) nanoparticles (NPs, 2, 4, 6, 8, and 10 wt.-% w.r.

Polyvinylidene Fluoride/Aromatic Hyperbranched Polyester of Third-Generation-Based Electrospun Nanofiber as a Self-Powered Triboelectric Nanogenerator for Wearable Energy Harvesting and Health Monitoring Applications.

Flexible pressure sensors have played an increasingly important role in the Internet of Things and human-machine interaction systems. For a sensor device to be commercially viable, it is essential to fabricate a sensor with higher sensitivity and lower power consumption. Polyvinylidene fluoride (PVDF)-based triboelectric nanogenerators (TENGs) prepared by electrospinning are widely used in self-powered electronics owing to their exceptional voltage generation performance and flexible nature.

Biopolymer Based Multifunctional Films Loaded with Anthocyanin Rich Floral Extract and ZnO Nano Particles for Smart Packaging and Wound Healing Applications.

There are significant societal repercussions from our excessive use of plastic products derived from petroleum. In response to the increasing environmental implications of plastic wastes, biodegradable materials have been proven to be an effective means of mitigating environmental issues. Therefore, protein- and polysaccharide-based polymers have gained widespread attention recently.

Revision to the musculoskeletal domain of the BILAG-2004 index to incorporate ultrasound findings.

Objectives: To improve the definitions of inflammatory arthritis within the musculoskeletal (MSK) domain of the BILAG-2004 index by incorporating imaging findings and clinical features predictive of response to treatment.

Methods: The BILAG MSK Subcommittee proposed revisions to the BILAG-2004 index definitions of inflammatory arthritis, based on review of evidence in two recent studies. Data from these studies were pooled and analysed to determine the impact of the proposed changes on the severity grading of inflammatory arthritis.

Management of systemic sclerosis: British Society for Rheumatology guideline scope.

This guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in evidence-based treatment and increased knowledge about assessment, classification and management. General approaches to management as well as treatment of specific complications will be covered, including lung, cardiac, renal and gastrointestinal tract disease, as well as RP, digital vasculopathy, skin manifestations, calcinosis and impact on quality of life. It will include guidance related to emerging approved therapies for interstitial lung disease and account for National Health Service England prescribing policies and national guidance relevant to SSc.

Cataract surgical training among residents in India: Results from a survey.

Purpose: To assess the quantum of cataract surgical training opportunities for trainees enrolled in ophthalmology residency programs in India.

Methods: An anonymous online survey was sent across to resident ophthalmologists across India through various social media platforms. The results were tabulated and analyzed.

Interaction of sugar stabilised silver nanoparticles with Momordica charantia seed lectin, a type II ribosome inactivating protein.

Sugar-stabilised nanomaterials have received a lot of attention in cancer therapy in recent years due to their pronounced application as specific targeting agents and maximizing their therapeutic potential while bypassing off-target effects. Lectins, the carbohydrate-binding proteins, are capable of binding to receptors present on the target cell/tissue and interact with transformed glycans better than normal cells. Besides some of the lectins exhibit anticancer activity.

The performance enhancement of solar cooker integrated with photovoltaic module and evacuated tubes using ZnO/Acalypha Indica leaf extract: response surface study analysis.

In this study, the effect of employing ZnO/Acalypha Indica leaf extract (ZAE) on the energy absorption of a coated portable solar cooker has been examined using an experimental setup. A prototypical model has been developed to corroborate in associating an investigative outcome per constituents of the experiments. The studied heat transfer process in ZAE is stable for harsh conditions.

Artificial intelligence based health indicator extraction and disease symptoms identification using medical hypothesis models.

Patient health record analysis models assist the medical field to understand the current stands and medical needs. Similarly, collecting and analyzing the disease features are the best practice for encouraging medical researchers to understand the research problems. Various research works evolve the way of medical data analysis schemes to know the actual challenges against the diseases.

The BILAG-2004 index is associated with development of new damage in SLE.

Objective: To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined.

Methods: This was a multicentre longitudinal study.

Detecting and Extracting Brain Hemorrhages from CT Images Using Generative Convolutional Imaging Scheme.

Purpose: The need for computerized medical assistance for accurate detection of brain hemorrhage from Computer Tomography (CT) images is more mandatory than conventional clinical tests. Recent technologies and advanced computerized algorithms follow Artificial Intelligence (AI), Machine Learning (ML), and Deep Learning (DL) techniques to improve medical diagnosis platforms. This technology is making the diagnosis practice of brain issues easier for medical practitioners to analyze and identify diseases with an assured degree of precision and performance.

BF·OEt catalyzed decarbonylative arylation/C-H functionalization of diazoamides with arylaldehydes: synthesis of substituted 3-aryloxindoles.

A metal-free BF·OEt catalyzed direct decarbonylative arylation of diazoamides with readily accessible aryl aldehydes under an open-air atmosphere was developed to afford 3-aryloxindoles 1,2-aryl migration with high selectivity. The reaction offers an efficient pathway for 3-arylation of diazoamides under relatively mild conditions, which shows a high level of functional group tolerance of both electron-donating and electron-withdrawing groups with a broad substrate scope. 3-Aryloxindoles were also obtained by a substituent-controlled chemo- and site-selective C-H bond functionalization of unprotected salicylaldehyde derivatives.

BF·OEt catalyzed chemoselective CC bond cleavage of α,β-enones: an unexpected synthesis of 3-alkylated oxindoles and spiro-indolooxiranes.

A BF·OEt catalyzed highly chemoselective formal CC double bond cleavage reaction of α,β-enones with diazoamides for the synthesis of 3-alkylated oxindoles is developed. Boron trifluoride etherate is found to be an effective catalyst for the chemoselective C-C cleavage of enones to obtain 3-alkylated oxindoles. The product formation indicates a selective β-carbon elimination pathway of α,β-enones using the inexpensive BF·OEt as a catalyst, transition metal-free conditions, an open-air environment, good functional tolerance and broad substrate scope.

Fecal microbiome and bile acid metabolome in adult short bowel syndrome.

Loss of functional small bowel surface area causes short bowel syndrome (SBS), intestinal failure, and parenteral nutrition (PN) dependence. The gut adaptive response following resection may be difficult to predict, and it may take up to 2 yr to determine which patients will wean from PN. Here, we examined features of gut microbiota and bile acid (BA) metabolism in determining adaptation and ability to wean from PN.

Microcontroller PIC 16F877A standard based on solar cooker using PV-evacuated tubes with an extension of heat integrated energy system.

The unavailability of sunlight during nighttime and cloudy weather condition has limited the usage of solar cookers throughout the day. This study will attempt to engineer a solar cooker with PV (photovoltaic panel), evacuated tubes with CPC reflectors, battery, and charge controller using the microcontroller PIC 16F877A. A mathematical model is developed to predict the electrical power (E) required during cloudy weather condition and nighttime as well as the temperatures occurring at different parts of the cooker.

Comparison of Responsiveness of British Isles Lupus Assessment Group 2004 Index, Systemic Lupus Erythematosus Disease Activity Index 2000, and British Isles Lupus Assessment Group 2004 Systems Tally.

Objective: To compare the responsiveness of the British Isles Lupus Assessment Group 2004 index (BILAG-2004) and the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) disease activity indices and to determine whether there was any added value in combining BILAG-2004, BILAG-2004 system tally (BST), or simplified BST (sBST) with SLEDAI-2K.

Methods: This was a multicenter longitudinal study of SLE patients. Data were collected on BILAG-2004, SLEDAI-2K, and therapy on consecutive assessments in routine practice.

Copper-catalyzed synthesis of spiro-indolofurobenzopyrans: tandem reactions of diazoamides and O-propargyl salicylaldehydes.

An atom-economical synthesis of spiro-indolofurobenzopyrans was developed from diazoamides and O-propargyl salicylaldehydes in the presence of copper(i) thiophene-2-carboxylate in a diastereoselective manner. This methodology involves the preparation of carbonyl ylide intermediates followed by 1,3-dipolar cycloaddition with internal/external alkynes, offering a great potential for constructing biologically significant spiro-indolofurobenzopyrans, as thermodynamically controlled products, in a tandem manner.