Polycyclic aromatic hydrocarbons (PAHs), one of the major environmental pollutants, produced from incomplete combustion of materials like coal, oil, gas, wood, and charbroiled meat, that contaminate the air, soil, and water, necessitating urgent remediation. Understanding the metabolic pathways for PAHs degradation is crucial to preventing environmental damage and health issues. Biological methods are gaining increasing interest due to their cost-effectiveness and environmental friendliness.
View Article and Find Full Text PDFCancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefront of cancer research. This review highlights the important roles of DNA methylation, histone modifications and non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs, which are key regulators of cancer-related gene expression.
View Article and Find Full Text PDFBioinform Biol Insights
August 2024
The mitigation of cadmium (Cd) pollution, a significant ecological threat, is of paramount importance. harbors 2 Cd resistance genes, namely, and . Presently, our focus is on the identification and characterization of the cation-transporting P-type ATPase (cadA) in BC15 through methods.
View Article and Find Full Text PDFMale breast cancer (MBC), one of the rare types of cancer among men where the global incidence rate is 1.8% of all breast cancers cases with a yearly increase in a pace of 1.1%.
View Article and Find Full Text PDFEnviron Monit Assess
December 2023
There is an urgent requirement for the improvement of the white leg shrimp, Litopenaeus vannamei; health-related indices; and immunity due to emerging diseases. Recently, probiotics have been playing an important role in L. vannamei health management.
View Article and Find Full Text PDFBackground: Boerhaavia diffusa is a medicinal herb with anti-inflammatory, antiproliferative, anticancer, and immunomodulatory properties, found across India.
Aim And Objectives: The present study is designed to investigate the therapeutic potential for B. diffusa root extracts in oral cancer cell line.
J Food Biochem
December 2022
Oxidative stress plays a vital role in the initiation and progression of diabetic cardiomyopathy (DCM). Increased cardiac dysfunction and apoptosis in DCM are independent factors associated with hypertension or coronary artery disease. Fucoidan, a class of sulfated polysaccharides, is widely used as food supplements and reported to have various pharmacological properties.
View Article and Find Full Text PDFCadmium (Cd) remediation in is achieved through the function of two vital genes, and , that code for P-type ATPase (CadA) and transcription regulatory protein (CadR), respectively. Although numerous studies are available on these metal-sensing and regulatory proteins, the promoter of these genes, metal sensing and binding ability, are poorly understood. The present work is aimed at the characterization of the CadR protein, identification of the P promoter and protein-promoter-metal binding affinity using bioinformatics and to validate the results by cloning the P promoter in DH5α.
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