SYNTHESIS OF FLUORO AND NITRO PYRAZOLINE DERIVATIVES: ANTICANCER AND MOLECULAR DOCKING STUDIES.

A series of novel fluoro and nitro pyrazoline derivatives (3a-3f and 4a-4e) was synthesized and characterized using various spectroscopic techniques. Initially, the Claisen-Schmidt condensation reaction was used to synthesize chalcone derivatives. The reaction between 5-bromo-2-acetyl thiophene with various substituted pyrazole aldehydes in the presence of PEG-400 (green solvent) gives a high yield of chalcones.