Publications by authors named "Prabesh Khatiwada"
Androgen receptor (AR) and its constitutively active splice variant, AR Variant 7 (AR-V7), regulate genes essential for the development and progression of prostate cancer. Degradation of AR and AR-V7 by the ubiquitination proteasomal pathway is important for the regulation of both their protein stability. Our published results demonstrate that the interaction of TM4SF3 with either AR or AR-V7 leads to mutual stabilization due to a reduction in their ubiquitination and proteasomal degradation.
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- T cell immunity is crucial for outcomes in COVID-19 and may offer better protection via targeted vaccination and therapy, especially for immunocompromised individuals.
- Research shows that prior infections with non-SARS coronaviruses can lead to pre-existing T cell memory that recognizes SARS-CoV-2 antigens, aiding in responses to the virus and its variants.
- Findings indicate that COVID-19 survivors have robust T cell responses against multiple SARS-CoV-2 proteins, with some non-SARS coronaviruses exhibiting cross-reactivity, suggesting potential for developing universal vaccines and therapies.
Androgen receptor (AR) plays a vital role in the development and progression of prostate cancer from the primary stage to the usually lethal stage known as castration-resistant prostate cancer (CRPC). Constitutively active AR splice variants (AR-Vs) lacking the ligand-binding domain are partially responsible for the abnormal activation of AR and may be involved in resistance to AR-targeting drugs occurring in CRPC. There is increasing consensus on the potential of drugs targeting protein-protein interactions.
View Article and Find Full Text PDFProstate cancer transitions from an early treatable form to the lethal castration-resistant prostate cancer (CRPC). Androgen receptor (AR) and constitutively active AR splice variants, such as AR-V7, may be major drivers of CRPC. Our laboratory recently identified a novel mechanism of AR regulation via the transmembrane protein transmembrane 4 superfamily 3 (TM4SF3), which exhibits a physical interaction, nuclear colocalization, and mutual stabilization with AR.
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- * Pre-existing T cell memory from past infections with common cold coronaviruses may help in responding to SARS-CoV2 and its variants, although the extent of cross-immunity is still unclear.
- * Research shows that COVID-19 survivors have strong T cell responses to SARS-CoV2 and related coronaviruses, suggesting a potential approach for developing universal vaccines and cell-based therapies against various coronaviruses.
Prostate cancer starts as a treatable hormone-dependent disease, but often ends in a drug-resistant form called castration-resistant prostate cancer (CRPC). Despite the development of the antiandrogens enzalutamide and abiraterone for CRPC, which target the androgen receptor (AR), drug resistance usually develops within 6 months and metastatic CRPC (mCRPC) leads to lethality. EZH2, found with SUZ12, EED, and RbAP48 in Polycomb repressive complex 2 (PRC2), has emerged as an alternative target for the treatment of deadly mCRPC.
View Article and Find Full Text PDFTwist1, a basic helix-loop-helix transcription factor that regulates a number of genes involved in epithelial-to-mesenchymal transition (EMT), is upregulated in prostate cancer. Androgen regulation of Twist1 has been reported in a previous study. However, the mechanism of androgen regulation of the Twist1 gene is not understood because the Twist1 promoter lacks androgen receptor (AR)-responsive elements.
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