Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women.

The mechanisms by which aerobic fitness confers beneficial effects on cognition with aging are unclear but may involve cerebrovascular adaptations. In a cross-sectional study of women from the community (n=42; age range=50-90 years), we sought to determine whether physical fitness is associated with higher cerebrovascular function, and its relationship to cognition. Main outcome measures included resting cerebral blood flow, cerebrovascular reserve, physical fitness (i.

Validation of an FFQ for evaluation of EPA and DHA intake.

Objective: To validate an FFQ for the assessment of dietary EPA and DHA against their relative concentrations in red blood cells (RBC).

Design: Cross-sectional analysis of baseline data. Intakes of marine food products and EPA and DHA were estimated by FFQ on the basis of consumption of marine food products in the last month.

Relationship between oxidative stress and HIF-1 alpha mRNA during sustained hypoxia in humans.

The aim of this study was to investigate the relations among reactive oxygen species (ROS), hypoxia inducible factor (HIF-1 alpha) gene expression, HIF-1 alpha target gene erythropoietin (EPO), and vascular endothelium growth factor (VEGF) in humans. Five healthy men (32+/-7 years, mean+/-SD) were exposed to 12 h of sustained poikilocapnic hypoxia (P(ET)O(2)=60 mmHg). DNA oxidation (8-hydroxy-2'-deoxyguanosine, 8-OHdG), advanced oxidation protein products (AOPP), EPO, and VEGF were measured in plasma and HIF-1 alpha mRNA was assessed in leukocytes before and after 1, 2, 4, 6, 8, 10, and 12 h of exposure to hypoxia.

Ventilatory and cerebrovascular responses to hypercapnia in patients with obstructive sleep apnoea: effect of CPAP therapy.

The purpose of this study was to assess whether the cerebrovascular response to hypercapnia is blunted in OSA patients and if this could alter the ventilatory response to hypercapnia before and after CPAP therapy. We measured the cerebrovascular, cardiovascular and ventilatory responses to hypercapnia in 8 patients with OSA (apnoea-hypopnoea index=101+/-10) before and after 4-6 weeks of CPAP therapy and in 10 control subjects who did not undergo CPAP therapy. The cerebrovascular and ventilatory responses to hypercapnia were not different between OSA and controls at baseline or follow-up.

Acceptance of repeat population-based voluntary counselling and testing for HIV in rural Malawi.

Objective: To examine the acceptance of repeat population-based voluntary counselling and testing (VCT) for HIV in rural Malawi.

Methods: Behavioural and biomarker data were collected in 2004 and 2006 from approximately 3000 adult respondents. In 2004, oral swab specimens were collected and analysed using ELISA and confirmatory Western blot tests, while finger-prick rapid testing was done in 2006.

Effects of ovarian hormones and aging on respiratory sinus arrhythmia and breathing patterns in women.

We investigated the effect of ovarian hormones and aging on breathing pattern [pulmonary minute ventilation (V(E))], tidal volume (V(T)), breathing frequency (F(b)), and respiratory sinus arrhythmia (RSA) in women. Recordings of V(E) and electrocardiogram (ECG) were obtained from 23 healthy women (10 premenopausal, 13 postmenopausal) under resting, isocapnic hypoxia (IH), and euoxic hypercapnia (EH) conditions. Premenopausal women were tested on three different days, each day corresponding to a specific phase of the menstrual cycle (follicular, mid-cycle, and luteal); postmenopausal women (PMW) were tested on 1 day only.

World benevolence beliefs and well-being across the life span.

Do people's worldviews change across the life course? Beliefs in the benevolence (goodness) of the world and their relations with age and well-being were examined in a 2-year study of a nationally representative sample (N = 2,138) ranging in age from 18 to 101 years. Multilevel modeling analyses controlling for demographics, mental health history, prior experience with stressful life events, and other key beliefs indicated that benevolence beliefs were positively associated with well-being and that these associations were stronger with increasing age. Analyses also demonstrated that individuals' benevolence beliefs increased during the study, were positively associated with age, and increased with the experience of bereavement, although they declined with the experience of other negative events.

Cardiovascular and cerebrovascular responses to acute isocapnic and poikilocapnic hypoxia in humans.

We examined the cardiovascular and cerebrovascular responses to acute isocapnic (IH) and poikilocapnic hypoxia (PH) in 10 men (25.7 +/- 4.2 yr, mean +/- SD).

Terrorism, acute stress, and cardiovascular health: a 3-year national study following the September 11th attacks.

Context: The terrorist attacks of 9/11 (September 11, 2001) present an unusual opportunity to examine prospectively the physical health impact of extreme stress in a national sample.

Objective: To examine the degree to which acute stress reactions to the 9/11 terrorist attacks predict cardiovascular outcomes in a national probability sample over the subsequent 3 years.

Design, Setting, And Participants: A national probability sample of 2729 adults (78.

Variability of middle cerebral artery blood flow with hypercapnia in women.

We examined the effect of euoxic hypercapnia on middle cerebral artery (MCA) blood flow velocity waveform parameters in pre- and postmenopausal women by exposing 24 healthy women (12 pre-, 12 postmenopausal) to hypercapnia for 20 min. MCA blood flow velocity was measured continuously by transcranial Doppler ultrasound. The data were run through an algorithm that detected the feature points of the waveforms and then analyzed for statistically significant group differences.

Risk and prevention of meningococcal disease among education workers: A review.

The aims of the present study were to review the risk of invasive meningococcal disease (IMD) among education workers, particularly pregnant women, and to evaluate preventive measures, in a context of endemicity, outbreak or epidemic as observed in the province of Quebec. The literature was reviewed and persons in charge of IMD surveillance in France, Quebec, the United Kingdom and the United States were interviewed. Surveys of asymptomatic carriage of Neisseria meningitidis show that transmission among students is higher than transmission between students and teachers.

Parental response and adolescent adjustment to the September 11, 2001 terrorist attacks.

This study examined adolescents' adjustment following the attacks of September 11, 2001 (9/11). A Web-based survey was administered 2 weeks and 7 months postattacks to a national sample of adolescents (N = 104). A randomly selected parent also completed a survey at the 7-month assessment.

Cerebral blood flow and ventilatory sensitivity to CO2 measured with the modified rebreathing method.

The ventilatory response to carbon dioxide (CO2) measured by modified rebreathing (SrVE) is closer to that measured by the steady-state method (SsVE) than is the response measured by Read's rebreathing method. Furthermore, the value estimated by the steady-state method depends upon the number of data points used to measure it. We planned to assess if these observations were also true for cerebral blood flow (CBF), as measured by steady-state (SsCBF) and modified rebreathing (SrCBF) tests.

Multivariate system identification for cerebral autoregulation.

The effect of spontaneous beat-to-beat mean arterial blood pressure (ABP) fluctuations and breath-to-breath end-tidal carbon dioxide (PETCO2) and end-tidal oxygen (PETO2) fluctuations on beat-to-beat cerebral bloodflow velocity (CBFV) variations is studied using a multiple coherence function. Multiple coherence is a measure of the extent to which the output, CBFV, can be represented as a linear time invariant system of multiple input signals. Analysis of experimental measurements from 13 different healthy subjects reveal that, with additional inputs, PETCO2 and PETO2, the multiple coherence for frequencies <0.

Differential responses of circulating amylin to high-fat vs. high-carbohydrate meal in healthy men.

Objective: The success of an amylin analogue in weight loss trials has generated interest in amylin as a physiological satiety signal. Little is known about how plasma amylin responds to macronutrients. This study examined the effects of a high-carbohydrate meal (CHO), a high-fat meal (FAT) or a continued fast (FAST) on amylin concentrations and correlations among other satiety hormones and measures of appetite.

Nonlinear, multiple-input modeling of cerebral hemodynamics during baseline and hypercapnia in young and post-menopausal women.

Normal aging is associated with changes in the cardiovascular system and more specifically in cerebral circulation. Sex-dependent changes in cerebrovascular CO2 reactivity, which may be related to hormonal levels, have been also reported. We therefore examined cerebral hemodynamics, i.

Management of antipsychotic-induced weight gain: prospective naturalistic study of the effectiveness of a supervised exercise programme.

Objective: To determine the potential effectiveness of a behavioural weight control programme including physical exercise in the prevention of antipsychotic-induced weight gain and associated comorbid conditions in outpatients with schizophrenia and mood disorders.

Methods: A prospective, comparative, open and naturalistic study was carried out for a total of 110 patients with schizophrenia, schizoaffective or bipolar disorders (DSM-IV), on treatment with atypical antipsychotics. Of these, 59 patients participated in an 18 month weight control programme that included an educational activity about dietary and physical activity counselling as well as a structured, supervised, facility-based exercise programme.

Sex, money, and premarital partnerships in southern Malawi.

In this paper, I argue two main points. First, in premarital, sexual partnerships in rural Malawi, the purpose of money exchange extends beyond the alleviation of female partners' economic constraints, and, second, by clarifying this broader purpose, it becomes possible to recognize where women exert control over their own sexual selves. These findings come from field observations and a rich set of in-depth interviews (N=54), bolstered on occasion by survey data, conducted with young women and men, aged 15-24 years, in the Balaka district in the southern region of the country.

Search for evidence of recurring or persistent viruses in Crohn's disease.

New-onset Crohn's disease and acute flares are often associated with viral infections. The aim of this study was to search for evidence of persistent or recurrent viruses in patients. Tissue blocks were obtained from surgical specimens from patients and a control population.