Publications by authors named "Poul-Flemming Hoeilund-Carlsen"
J Drug Target
November 2016
Article Synopsis
- The story begins in Basel, 2013, where Pieter introduces a solvent-exchange method for creating limit-sized nanoparticles aimed at delivering drugs to cancer cells using Low Density Lipoprotein (LDL) as a vehicle.
- The research emphasizes the bottom-up design process, detailing the stages of nucleation and growth of nanoparticles, demonstrating that classic nucleation theory can accurately predict nanoparticle sizes using the right parameters.
- Calculations show that smaller nanoparticles (50 nm) dissolve much faster than larger ones (500 nm) in the bloodstream, making them more effective for drug delivery; the study experiments with various nanoparticles, emphasizing the importance of an impermeable lipid coating.
