Subcutaneous and Topical Tranexamic Acid Use During Rhytidectomy.

Objective: Tranexamic acid is a potential rhytidectomy adjunct; however, its route of administration, benefits, and safety remain a topic of debate. The purpose of this study is to analyze the effects of topical and subcutaneous TXA during rhytidectomy.

Methods: This is a retrospective, 3-arm analysis of a single surgeon's practice from Aug.

Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications.

Chronic wounds are a major healthcare problem, but their healing may be improved by developing biomaterials which can stimulate angiogenesis, e.g. by activating the Hypoxia Inducible Factor (HIF) pathway.

Laser-Deposited Beta Type Ti-42Nb Alloy with Anisotropic Mechanical Properties for Pioneering Biomedical Implants with a Very Low Elastic Modulus.

Present commercial titanium alloy implants have an elastic modulus higher than 100 GPa, whereas that of the cortical bone is much smaller (17−28 GPa). This elastic modulus mismatch produces a stress shielding effect and the resorption of the bone surrounding the implant. In the present work, a <100> fiber texture is developed in β type Ti-42Nb (wt%) alloy ingots generated by laser-directed energy deposition (LDED) in order to achieve anisotropic mechanical properties.

Silver Nanoparticles Produced by Laser Ablation and Re-Irradiation Are Effective Preventing Peri-Implantitis Multispecies Biofilm Formation.

Implant-associated infection due to biofilm formation is a growing problem. Given that silver nanoparticles (Ag-NPs) have shown antibacterial effects, our goal is to study their effect against multispecies biofilm involved in the development of peri-implantitis. To this purpose, Ag-NPs were synthesized by laser ablation in de-ionized water using two different lasers, leading to the production of colloidal suspensions.

Preserving Nasal Tip Rotation and Projection in Open Septorhinoplasty.

Open septorhinoplasty is a common facial plastic surgery procedure that requires extensive planning and knowledge to achieve predictable outcomes. Many patients want to keep their nasal tip characteristics, and the surgeon's task is to reliably meet this expectation and provide stable long-term results. Techniques used to reconstruct nasal tip support include the tongue-in-groove, caudal septal extension graft, and caudal septal replacement graft procedures.

Palladium Nanoparticles Synthesized by Laser Ablation in Liquids for Antimicrobial Applications.

Antibiotic resistance is a leading cause of death worldwide. In this paper, we explore new alternatives in the treatment of infections. Noble metal nanoparticles could help to mitigate this problem.

3D printing with star-shaped strands: A new approach to enhance in vivo bone regeneration.

Concave surfaces have shown to promote bone regeneration in vivo. However, bone scaffolds obtained by direct ink writing, one of the most promising approaches for the fabrication of personalized bone grafts, consist mostly of convex surfaces, since they are obtained by microextrusion of cylindrical strands. By modifying the geometry of the nozzle, it is possible to print 3D structures composed of non-cylindrical strands and favor the presence of concave surfaces.

Characterization of Co-Cr-W Dental Alloys with Veneering Materials Manufactured via Subtractive Milling and Additive Manufacturing LDED Methods.

Laser-directed energy deposition (LDED) is an additive manufacturing (AM) technology which can be an alternative to the traditional subtractive milling process for the obtention of porcelain-fused-to-metal (PFM) prosthesis. Still, the adhesion performance of the veneering ceramics for this material has been not studied yet. The main objective of this study is to perform a systematic comparison of the adhesion performance of Co-Cr-W metal frameworks obtained through LDED and conventional milling techniques.

Health and access to healthcare in homeless people: Protocol for a mixed-methods study.

Background: Homelessness is a more complex problem than the simple lack of a place to live. Homeless people (HP) often suffer from poor health and premature death due to their limited access healthcare, and are also deprived of basic human and social rights. The study protocol described here aims to evaluate the complex relationship between homelessness and health, and identify the barriers and facilitators that impact access to healthcare by HP.

Life Cycle Assessment of the Separation and Recycling of Fluorinated Gases Using Ionic Liquids in a Circular Economy Framework.

The stricter regulation regarding the use of fluorinated gases (F-gases), as a consequence of their high Global Warming Potential (GWP), represents a challenge for the refrigeration industry. The design of alternatives requires the recycling of the low to moderate GWP compounds from current refrigerant blends. However, there is not a developed and standardized technology available to recover them, and once the life cycle of the refrigeration equipment has ended, most gases are incinerated.

Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission.

Background: Early identification of COVID-19 patients at risk of critical illness is a challenging endeavor for clinicians. We aimed to establish immunological, virological, and routine laboratory markers, which, in combination with clinical information, may allow identifying such patients.

Methods: Blood tests to measure neutrophil/lymphocyte ratio (NLR) and levels of ferritin, CRP, D-dimer, complement components (C3 and C4), cytokines, and lymphocyte subsets, as well as SARS-Cov-2 RT-PCR tests, were performed in COVID-19-confirmed cases within 48 hours of admission.

Monte Carlo simulation of a LSC based on stacked layers of fiber arrays with core-coating different absorbing properties.

In this work, a Monte Carlo ray-tracing model for the simulation and optimization of a fiber Luminescent Solar Concentrator (LSC) based on stacked layers of fiber arrays is developed and validated. The fiber LSC efficiency improvements are compared against a conventional planar LSC. We developed a new model to analyze the performance of different configurations of bulk-doped fibers and fibers constituted by a doped coating and a passive core.

Treating Nasal Valve Collapse in Facial Paralysis: What I Do Differently.

Patients with facial paralysis require a systematic zonal assessment. One frequently overlooked region is the effect of facial paralysis on nasal airflow. Patients with flaccid paralysis experience increased weight of the cheek and loss of muscle tone in the ala and sidewall; this significantly contributes to nasal valve narrowing and collapse.

Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium.

The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass micro- and nanofibres produced by laser spinning.

Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients.

Risk factors associated with severity and mortality attributable to COVID-19 have been reported in different cohorts, highlighting the occurrence of acute kidney injury (AKI) in 25% of them. Among other, SARS-CoV-2 targets renal tubular cells and can cause acute renal damage. The aim of the present study was to evaluate the usefulness of urinary parameters in predicting intensive care unit (ICU) admission, mortality and development of AKI in hospitalized patients with COVID-19.

Laser-Guided Corrosion Control: A New Approach to Tailor the Degradation of Mg-Alloys.

Despite corrosion being commonly seen as a problem to be avoided, applications such as batteries or biodegradable implants do benefit from corrosion-like phenomena. However, current strategies address corrosion control from a global perspective for a whole component, without considering local adaptations to functionality specifications or inhomogeneous environments. Here, a novel concept is presented: the local control and guidance of corrosion through a laser surface treatment.

Kinetics of the formation and destruction of PCDD/Fs in a laboratory tubular furnace.

A kinetic model has been developed for the formation of selected congeners of PCDD/Fs during the thermal decomposition of different wastes in a horizontal reactor. Previously published data on the decomposition of wastes have been correlated using a kinetic model that only considers process parameters, such as the presence of different amounts of oxygen in the atmosphere of reaction, chlorine and metals in the waste. The effect of both chlorine and metals is modelled through an equation assuming a "saturation effect", i.

A Novel Parent Questionnaire for the Detection of Seizures in Children of Spanish-Speaking Families.

Background: We developed and validated a Spanish seizure screen for children based on a previously validated English seizure screen that could be administered by a trained research assistant in a 2-step process, approximating the clinical diagnostic process of a pediatric epilepsy specialist. This questionnaire was designed to study seizure prevalence in a research population of children at risk for epilepsy.

Methods: Spanish-speaking parents of children 6 months to 17 years old were recruited from the pediatric neurology clinics at Boston Medical Center and interviewed using a computerized questionnaire.

Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study.

Introduction: Coronavirus disease 2019 (COVID-19) pneumonia is associated to systemic hyper-inflammation and abnormal coagulation profile. D-dimer elevation is particularly frequent, and values higher than 1μg/mL have been associated with disease severity and in-hospital mortality. Previous retrospective studies found a high pulmonary embolism (PE) prevalence, however, it should be highlighted that diagnoses were only completed when PE was clinically suspected.

Local Anesthetic Facelift.

A thorough medical history is critical in patient selection for local anesthesia facelifting. Patients with no prior issues with dental procedures and no history of significant anxiety are better candidates. Simplifying local anesthesia mixtures and using dilute concentrations will minimize dosing errors and decrease risk of local anesthesia toxicity.

Continuous fiberizing by laser melting (Cofiblas): Production of highly flexible glass nanofibers with effectively unlimited length.

The development of nanofibers is expected to foster the creation of outstanding lightweight nanocomposites and flexible and transparent composites for applications such as optoelectronics. However, the reduced length of existing nanofibers and nanotubes limits mechanical strengthening and effective manufacturing. Here, we present an innovative method that produces glass nanofibers with lengths that are, effectively, unlimited by the process.

Fabrication and Deposition of Copper and Copper Oxide Nanoparticles by Laser Ablation in Open Air.

The proximity of the "post-antibiotic era", where infections and minor injuries could be a cause of death, there are urges to seek an alternative for the cure of infectious diseases. Copper nanoparticles and their huge potential as a bactericidal agent could be a solution. In this work, Cu and Cu oxide nanoparticles were synthesized by laser ablation in open air and in argon atmosphere using 532 and 1064 nm radiation generated by nanosecond and picosecond Nd:YVO lasers, respectively, to be directly deposited onto Ti substrates.

A1 asynchrony, a potential risk factor for the rupture of anterior communicating artery aneurysms: A computational fluid dynamics study.

Introduction And Objectives: The anterior communicating complex is one the most common locations for aneurysm development. It receives blood from both carotid circulations and the effect of synchrony on the arrival of blood flow has not been previously studied. The objective of this study was to compare the asynchrony conditions of the A1 pulse and its effects on the haemodynamic conditions of anterior communicating artery (ACoA) aneurysms.

Laser Microdrilling of Slate Tiles.

Slate is a natural rock usually used in roofs, façades, and for tiling. In spite of this broad use, the production process of slate tiles requires substantial improvements. An important quantity of slate from the quarry is wasted during the manufacturing of the final product.