Functional Activity of Blood Neutrophils in Patients with Stable Course and Exacerbation of Chronic Obstructive Pulmonary Disease.

We performed a comparative study of the parameters of chemiluminescence of blood neutrophils in patients with different severity of chronic obstructive pulmonary disease in its different periods. The maximum values of induced and spontaneous chemiluminescence were recorded at moderate severity of the disease during exacerbation. Low levels of chemiluminescence indicators were found in severe chronic obstructive pulmonary disease in the stable phase.

The Clinical Management of Deconditioned Patient.

The current study was designed to investigate the clinical management of deconditioned patients. In the current study, we investigate the clinical manifestations of deconditioned patients. A subacute functional deficiency was determined when getting up from a supine position and developing tachycardia with an increase in heart rate by 30 or more per minute for 10 minutes.

Cognitive Impairments in Patients with Bronchial Asthma.

The course of bronchial asthma can be accompanied by cognitive impairments. However, the relationship between cognitive dysfunction and asthma has not been fully revealed, nor has it been fully established what causes cognitive impairments in patients with asthma. There is an opinion that transient hypoxia and persistent systemic inflammation with insufficient control of bronchial asthma can be accompanied by neurotoxicity in relation to the hippocampus and indirectly lead to deterioration of cognitive functions.

Comparative Study of the Levels of IL-1β, IL-4, IL-8, TNFα, and IFNγ in Stable Course and Exacerbation of Chronic Obstructive Pulmonary Disease of Varying Severity.

In patients with chronic obstructive pulmonary disease, the levels of cytokines IL-1β, IL-4, IL-8, TNFα, and IFNγ depended on the degree of bronchial obstruction and severity and period of the disease. The maximum levels of IL-4, IL-8, and TNFα were observed in severe chronic obstructive pulmonary disease during exacerbation. The highest concentration of IL-1β and IFNγ were recorded during activation of inflammation in patients with moderate bronchial obstruction.

The possible effect of lactoferrin on the epigenetic characteristics of early mammalian embryos exposed to bisphenol A.

Background: The main objective of this review was to state a hypothetical mechanism of the antitoxic effect of lactoferrin (Lf) on embryos exposed to bisphenol A (BPA). On this basis, it is possible to suggest Lf as a potential protective health component before conception upon toxic effects and viral infections.

Methods: The narrative review was performed using systematic review methods to identify relevant literature.

[Fatal severe community-acquired pneumonia: risk factors, clinical characteristics and medical errors of hospital patients].

Unlabelled: Community-acquired pneumonia (CAP) is the most common disease and potentially life-threatening infection in the worldwide. In the Nizhny Novgorod region, no analysis of the causes of mortality and medical errors of severe CAP patients.

Aim: To analyze the patients structure who died severe CAP in hospitals of the Nizhny Novgorod region, to identify the leading risk factors, to assess the clinical characteristics of fatal severe CAP and medical errors according to medical records of patients from 20152016.

Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients.

The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied.

Associations between indicators of nitrosative stress and levels of soluble HLA-I, CD95 molecules in patients with COPD.

At the present stage of study of chronic obstructive pulmonary disease (COPD) one of the problem is the definition of new criteria for the topical and systemic chronic inflammation of this disease. The aim of the research was to study the concentration of nitric oxide metabolites, the level of soluble human leukocyte antigens class I (sHLA-I) and of soluble CD95 molecules (sCD95) in the serum of blood and exhaled breath condensate (EBC) in patients with exacerbation of COPD. We investigated 49 moderate-to-severe COPD patients with exacerbation, and 21 healthy nonsmokers.

[Pneumoconioses in contemporary industry].

The article deals with features of development and formation of various pneumoconioses diagnosed after 1996: less benign course, early complaints, marked functional and X-ray changes in lungs, early complications--these result mainly from lower content of chemicals with fibrogenous effect in industrial aerosol and presence of allergic, cytotoxic and irritating agents. That helped to formulate a concept of contemporary pneumoconiosis caused by complex industrial aerosol over last 10-15 years.

[The clinical pathology of polymorbidity in geriatrics practice].

The original data about phenomenon of polymorbidity in geriatrics practice are presented in the article. Most often ways of the development of polymorbidity and their clinical outcomes are discussed.

[The levels of soluble CD95 antigen and CD95+ mononuclear cells in patients with chronic obstructive lung diseases].

The levels of soluble CD95 (sCD95) antigen and CD95+ mononuclear cells were studied in the peripheral blood, induced sputum (IS), expired air condensate (EAC) of patients with chronic obstructive pulmonary disease (COPD). There was an increase in the relative count of CD95+ mononuclear cells and a reduction in the level of sCD95 antigen in the peripheral blood of patients with severe COPD. The elevated levels of sCD95 antigen and CD95+ mononuclear cells were revealed in IS and EAC in moderate COPD.

[Gastric and duodenal ulcer disease: morphofunctional, neuroendocrine and clinical parallels].

Morphofunctional state of gastric mucous tunic and neuroendocrine cells, and clinical indices at various stages of gastric and duodenal ulcer disease was studied. It was shown, that in clinico-endoscopic remission stage of disease intensity of pathogenetic mechanisms of some neuroimmune-endocrine and clinical indices remained.

[Antihelicobacter effects of melatonin].

The authors made an attempt to find a new approach to Helicobacter pylori (HP) eradication in patients with chronic gastritis and peptic ulcer without application of antibiotics, but using melatonin properties instead. The study demonstrates an undoubtful effect of melatonin as a preparation that favors HP eradication.

[Significance of biochemical parameters of saliva in the diagnosis of chronic obstructive pulmonary disease at exacerbation].

The levels of calcium, magnesium and iron were examined on an automated biochemical analyzer in saliva and blood serum of 102 patients with chronic obstructive disease of lungs (CODL) and of 20 healthy subjects. Reliably reduced levels of magnesium and iron in saliva as well as low permeability of the hematosalivary barrier (HSB) for magnesium and its high permeability for iron were detected in group 2 and 3 of patients. The dynamic level of iron in saliva reached the normal value, whereas, a stable salivary deficiency was typical of magnesium.

[Metabolism of proinflammatory cytokine (interleukin-1 beta) and oxidant activity of neutrophils in various forms of chronic bronchitis].

Aim: To study content of interleukin-1 beta (IL-1 beta) and free radical oxidation in neutrophils of blood, saliva and bronchoalveolar lavage (BAL) in chronic bronchitis for prediction of obstructive defects.

Material And Methods: Enzyme immunoassay was used to measure IL-1 beta in the blood, saliva, BAL of 49 males with chronic bronchitis aged 39-72 years. Functional ability of the neutrophils to generate free oxygen radicals was assessed by luminol-dependent chemiluminescence.

[Mucociliary function in acute pneumonia].

Radioaerosol method was employed to follow up mucociliary transport (MT) efficacy in 97 patients with acute pneumonia (AP). The most pronounced suppression of MT was found in repeated and lingering AP. If causative agents were represented by adenoviruses, streptococci and influenza bacillus suppression of MT appeared more noticeable.

[Participation of sanitary and epidemiological stations in health promoting activities among population].

Materials regarding the main directions and forms of participation of sanitary and epidemiological station (SES) specialists in the process of overall dispensarization of population, supply of information, the evaluation of the performance of different subdivisions and SES specialists are provided. Along with the organization of control and supervision while conducting sanitary and hygienic and anti-epidemic measures at the territories within the jurisdiction of SES, the role and participation of sanitary and epidemiological institutions in the control of health status in view of harmful effect of environmental factors and prevention of diseases among population are demonstrated.