Effects of the IronHand Soft Exoskeleton on Forearm Muscle Activity During in Field Automotive Assembly Tasks.

OCCUPATIONAL APPLICATIONSWhen compared to not using a soft-hand exoskeleton, the IronHand caused both increases and decreases in forearm muscle activity while completing automotive assembly tasks. Surprisingly, although there were reductions in muscle activity when wearing the IronHand, only a few of these decreases resulted in muscle activity changing such that they fell to below recommended ergonomic thresholds. Despite this, some individuals in our study clearly benefited from the device, and this suggests that there is potential for widespread use of such a device if fine tuned to the individual and task demands.

Signatures of Ultralight Bosons in the Orbital Eccentricity of Binary Black Holes.

We show that the existence of clouds of ultralight particles surrounding black holes during their cosmological history as members of a binary system can leave a measurable imprint on the distribution of masses and orbital eccentricities observable with future gravitational-wave detectors. Notably, we find that for nonprecessing binaries with chirp masses M≲10M_{⊙}, formed exclusively in isolation, larger-than-expected values of the eccentricity, i.e.

Local in Time Conservative Binary Dynamics at Fourth Post-Minkowskian Order.

Leveraging scattering information to describe binary systems in generic orbits requires identifying local and nonlocal in time tail effects. We report here the derivation of the universal (nonspinning) local in time conservative dynamics at fourth post-Minkowskian order, i.e.

Food plants in Brazil: origin, economic value of pollination and pollinator shortage risk.

Pollination is a key ecosystem service of critical importance for food production. However, globally, several regions are already experiencing pollinator shortage as pollinators are declining. Here, we investigate the origin, pollinator dependence and economic value of 199 food crops cultivated in Brazil to understand to which extent (1) Brazilian agriculture is vulnerable to pollinator shortage, and (2) Brazilian society has already achieved a comprehensive perspective about crop dependence.

Emotional Value of Fear Memory and the Role of the Ventral Hippocampus in Systems Consolidation.

Recent studies have explored the circuitry involving the ventral hippocampus (vHPC), the amygdala, and the prefrontal cortex, a pathway mainly activated to store contextual information efficiently. Lesions in the vHPC impair remote memory, but not in the short term. However, how the vHPC is affected by distinct memory strength or its role in systems consolidation has not yet been elucidated.

Morita-Baylis-Hillman adducts and their derivatives: a patent-based exploration of diverse biological activities.

Morita-Baylis-Hillman adducts are polyfunctionalized compounds that result from a three-component reaction involving an electrophilic sp carbon (aldehyde, ketone or imine) and the α-position of an activated alkene, catalyzed by a tertiary amine. These adducts exhibit a wide range of biological activities and act as valuable starting materials for developing drug candidates, pesticides, polymers, and other applications. In this regard, the present review aimed to explore the biological potential of Morita-Baylis-Hillman adducts and their derivatives as documented in patent literature.

Equations for estimating the static supportive torque provided by upper-limb exoskeletons.

Upper-limb exoskeletons are gaining traction in industrial work environments. However, other than advertised general specifications (e.g.

Radiation Reaction and Gravitational Waves at Fourth Post-Minkowskian Order.

We obtain the total impulse in the scattering of nonspinning binaries in general relativity at fourth post-Minkowskian order, i.e., O(G^{4}), including linear, nonlinear, and hereditary radiation-reaction effects.

Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly.

Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological and environmental factors, the genetic host factors are suggested as important to the CZS occurrence and development, however, few studies have evaluated this. This study enrolled a total of 245 individuals in a case-control association study compound a cohort of high specific interest constituted by 75 mothers who had delivered CZS infants, their 76 infants, and 47 mothers that had delivered healthy infants, and their 47 infants.

Molecular Docking, ADMET Analysis and Molecular Dynamics (MD) Simulation to Identify Synthetic Isoquinolines as Potential Inhibitors of SARS-CoV-2 M.

Background: The rapidly widespread SARS-CoV-2 infection has affected millions worldwide, thus becoming a global health emergency. Although vaccines are already available, there are still new COVID-19 cases daily worldwide, mainly due to low immunization coverage and the advent of new strains. Therefore, there is an utmost need for the discovery of lead compounds to treat COVID-19.

NMR-based metabolomics applied to ecotoxicology with zebrafish (Danio rerio) as a prominent model for metabolic profiling and biomarker discovery: Overviewing the most recent approaches.

Metabolomics is an innovative approach used in the medical, toxicological, and biological sciences. As an interdisciplinary topic, metabolomics and its relation with the environment and toxicological research are extensive. The use of substances, such as drugs and pesticides, contributes to the continuous releasing of xenobiotics into the environment, harming organisms and their habitats.

Protein-coding gene interaction network prediction of bioactive plant compound action against SARS-CoV-2: a novel hypothesis using bioinformatics analysis.

This study aimed to verify the action of bioactive compounds from Brazilian plants on the leader genes involved in the SARS-CoV-2 pathway. The main human genes involved were identified in GeneCards and UNIPROT platforms, and an interaction network between leader genes was established in the STRING database. To design chemo-biology interactome networks and elucidate the interplay between genes related to the disease and bioactive plant compounds, the metasearch engine STITCH 3.

Physical capability limits for right-angle power tool operation.

Automotive assembly operations require power tools to secure fasteners and these operations have been linked to increased risk of musculoskeletal disorders. This work was designed to develop physical capability limits for direct current right-angle power tool (RAPT) operations using psychophysics. Forty females fastened joints of different hardness's using three fastening strategies, at three fastening frequencies.

Effect of exercise on female pelvic floor morphology and muscle function: a systematic review.

Introduction And Hypothesis: The objective was to synthesize the scientific evidence on the relationship of exercise with morphology and muscle function parameters of the female pelvic floor. The design was a systematic review.

Methods: Searches were performed in MEDLINE, PubMed, CINAHL, Web of Science, SCOPUS, SportDiscuss, and Google Scholar up to April 2021.

A review on membrane concentrate management from landfill leachate treatment plants: The relevance of resource recovery to close the leachate treatment loop.

Membrane filtration processes have been used to treat landfill leachate. On the other hand, closing the leachate treatment loop and finding a final destination for landfill leachate membrane concentrate (LLMC) - residual stream of membrane systems - is challenging for landfill operators. The re-introduction of LLMC into the landfill is typical; however, this approach is critical as concentrate pollutants may accumulate in the leachate treatment facility.

Conservative Dynamics of Binary Systems at Fourth Post-Minkowskian Order in the Large-Eccentricity Expansion.

We compute the conservative dynamics of nonspinning binaries at fourth post-Minkowskian order in the large-eccentricity limit, including both potential and radiation-reaction tail effects. This is achieved by obtaining the scattering angle in the worldline effective field theory approach and deriving the bound radial action via analytic continuation. The associated integrals are bootstrapped to all orders in velocities through differential equations, with boundary conditions in the potential and radiation regions.

Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite .

The intravascular parasitic worm is a causative agent of schistosomiasis, a disease of great global public health significance. Praziquantel is the only drug available to treat schistosomiasis and there is an urgent demand for new anthelmintic agents. Adopting a phenotypic drug screening strategy, here, we evaluated the antiparasitic properties of 46 commercially available cardiovascular drugs against From these screenings, we found that amiodarone, telmisartan, propafenone, methyldopa, and doxazosin affected the viability of schistosomes in vitro, with effective concentrations of 50% (EC) and 90% (EC) values ranging from 8 to 50 µM.

A comparison of the physical demands associated with various right-angle direct-current power tools.

This work examined the physical demands associated with 4 commercially available direct current right-angle power tools along with their computer controlled fastening strategies. Physical demands were measured via an external instrumented handle that could also control the trigger of each tool. Data revealed that forces recorded by the external handle for each of the 4 tools differed.

Cardiovascular damage associated with subchronic exposure to the glyphosate herbicide in Wistar rats.

Glyphosate is the most widely used herbicide in the world. Although some studies have shown cardiac electrophysiological changes associated to glyphosate, the histopathological changes that this herbicide may cause in the cardiovascular system are not yet established. The aim of this study was to evaluate the cardiovascular effects of subchronic oral and inhalation exposure to the glyphosate herbicide in rats.

Physical demands associated with right-angle direct-current power-tools: An evaluation of current technology.

The purpose of this work was to evaluate the physical demands associated with three direct current powered right-angle power tool tightening strategies at various fastener-location-orientations, target torques and joint-hardness. Physical demands were measured using surface electromyography, handle force and upper body kinematics. Results identified TurboTight®, a rapid and short duration fastening strategy, to produce lower handle force impulse, less joint angle displacement, and lower EMG magnitudes when compared to the longer duration fastening strategies tested.

Recent progress in the synthesis of homotropane alkaloids adaline, euphococcinine and -methyleuphococcinine.

The 9-azabicyclo[3.3.1]nonane ring system is present in several insect- and plant-derived alkaloids.

Conservative Dynamics of Binary Systems to Third Post-Minkowskian Order from the Effective Field Theory Approach.

We derive the conservative dynamics of nonspinning binaries to third post-Minkowskian order, using the effective field theory (EFT) approach introduced in [G. Kälin and R. A.

A survey of right-angle power tool use in Canadian automotive assembly plants.

Right-angle power-tools (RAPT) employed in automotive manufacturing promote greater productivity and quality fastenings, as well as, improve process efficiency. Due to RAPT technological advances automotive manufactures desire to understand their ergonomics consequences within a laboratory environment, however, laboratory-based representation must accurately represent the real world. A survey within automotive assembly plants was conducted to capture RAPT operation data.

Signals of a Quantum Universe.

Structure in the Universe is widely believed to have originated from quantum fluctuations during an early epoch of accelerated expansion. Yet, the patterns we observe today do not distinguish between quantum or classical primordial fluctuations; current cosmological data are consistent with either possibility. We argue here that a detection of primordial non-Gaussianity can resolve the present situation, and provide a litmus test for the quantum origin of cosmic structure.