Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1.

Unlabelled: Experience-dependent cortical plasticity declines with age. At the molecular level, experience-dependent proteolytic activity of tissue plasminogen activator (tPA) becomes restricted in the adult brain if mice are raised in standard cages. Understanding the mechanism for the loss of permissive proteolytic activity is therefore a key link for improving function in adult brains.