[Acute hypoxic hypoxia increases lactate concentration in amniotic fluid of rabbits on 27-28th day of pregnancy].

We evaluated the influence of hypoxic hypoxia on lactate, creatinine and urea concentrations in the amniotic fluid (AF) of rabbits on 27-28th day of pregnancy. Rabbits were randomly sudivided into two groups: experimental (n=9) and control (n=6). Rabbits of experimental groups were placed in a hypoxic chamber containing 10±2% oxygen and 90±2% nitrogen for 1 h and then were euthanized, AF was extracted from the amniotic sacs via disposable syringe.

[The concentration of lactate in amniotic fluid in delivery under physiological course of pregnancy].

The study was carried out to establish admissible range of concentrations of lactate using standard biochemical method in amniotic fluid at first period of delivery under physiologically progressing pregnancy. The sampling included 44 women examined during first period of urgent delivery. The samples of amniotic fluid were taken during the first period of delivery using vaginal amnitomy.

Association of SNPs of CD40 gene with multiple sclerosis in Russians.

Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected the suggestive association of located upstream of CD40 gene in chromosome 20q13 (p = 1.3×10(-7)).

[The first results of a combined all-Russian study on clinical genetics of multiple sclerosis].

Multiple sclerosis is a classic multifactorial disease in which etiology interaction of external factors and structural features of a large number of genes plays an important role. Identifying risk factors for multiple sclerosis and creating an integrated model of pathogenesis are urgent tasks of neurology. Revealing true risk factors is possible only in studies with sufficient statistical power, so with a large amount of samples.

[Bone resorption and formation markers in women with climacteric syndrome in early postmenopause].

The level of bone metabolites and the indices of calcium and phosphorus metabolism were measured in 20 women with climacteric syndrome in postmenopause and in 20 women in premenopause, who had normal bone density and did not differ in the modified risk factors of osteoporosis. In the climacteric women, the normal bone density was accompanied by the elevated levels of CrossLaps and osteocalcin. There was no difference in the concentrations of parathormone, calcium, and phosphorus.

[Characteristics of a spermogram and metabolic parameters of active oxygen forms in the ejaculate of patients with chronic abacterial prostatitis].

Chronic inflammatory diseases of the prostate are accompanied by the accumulation of active oxygen forms and the activation of biopolymer peroxidation. The increased concentration of thiobarbituric acid reactive substances and the decreased activity of antioxidant enzymes in the ejaculate of patients with chronic abacterial prostatitis are attended by spermatozoon defects. It is suggested that correction of the metabolism of active oxygen forms in patients with chronic abacterial prostatitis has a positive effect.

[Defects in spermatogenesis and their correction in patients with chronic abacterial prostatitis].

A total of 28 males aged 20-46 years with chronic abacterial prostatitis (CAP) were divided into two groups. Group 1 patients received standard therapy (prostatotropic, vitamin, antioxidant); group 2 received the same standard treatment plus peloid therapy including silver-containing clay "Bekhtemirskaya". Eleven males with documented fertility (sperm donors) comprised a control group.