Publications by authors named "Popoff B"

Background: Intensive care units (ICUs) handle the most critical patients with a high risk of mortality. Due to those conditions, close monitoring is necessary and therefore, a large volume of data is collected. Collaborative ventures have enabled the emergence of large open access databases, leading to numerous publications in the field.

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Background: To reduce the number of deaths caused by exsanguination, the initial management of severe trauma aims to prevent, if not limit, the lethal triad, which consists of acidosis, coagulopathy, and hypothermia. Recently, several studies have suggested adding hypocalcemia to the lethal triad to form the lethal diamond, but the evidence supporting this change is limited. Therefore, the aim of this study was to compare the lethal triad and lethal diamond for their respective associations with 24-h mortality in severe trauma patients receiving transfusion.

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Article Synopsis
  • - The study aimed to determine if severe traumatic rhabdomyolysis (with CK levels > 5000 U/L) affects the likelihood of death within 30 days for trauma patients, utilizing a causal inference approach in a multicenter cohort in France.
  • - An analysis of 8592 patients revealed that 18% had severe RM, primarily affecting young males with blunt trauma, yet it did not significantly impact overall 30-day mortality rates despite associated complications.
  • - While patients with severe RM had higher rates of multiorgan failure and septic shock during ICU stays, this risk was not a significant predictor of death when adjusted for confounding factors.
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Massive transfusion of blood products poses challenges in determining the need for transfusion and the appropriate volume of blood products. This review explores the use of machine learning (ML) models to predict transfusion risk during surgical procedure, focusing on the methodology, variables, and software employed to predict transfusion. This scoping review investigates the development and current state of machine learning models for predicting transfusion risk during surgical procedure, aiming to inform physicians about the field's progress and potential directions.

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Background: Social media (SoMe) have taken a major place in the medical field, and younger generations are increasingly using them as their primary source to find information.

Objective: This study aimed to describe the use of SoMe for medical education among French medical students and assess the prevalence of smartphone addiction in this population.

Methods: A cross-sectional web-based survey was conducted among French medical students (second to sixth year of study).

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Background And Objective: The increasing implementation and use of electronic health records over the last few decades has made a significant volume of clinical data being available. Over the past 20 years, hospitals have also adopted and implemented data warehouse technology to facilitate the reuse of administrative and clinical data for research. However, the implementation of clinical data warehouses encounters a set of barriers: ethical, legislative, technical, human and organizational.

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Intensive care units (ICUs) provide care for critical patients at high risk of morbidity and mortality, and require continuous monitoring of clinical, biological and, imaging parameters. Collaborative ventures have enabled the emergence of large open access databases for the secondary use of Electronic Health Records (EHRs). The objective of this work was to evaluate the availability of scripts and datasets in publications based on ICU open-access databases.

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Article Synopsis
  • - The paper discusses a new visualization dashboard designed to display quality indicators for intensive care units (ICUs) utilizing the OMOP Common Data Model (CDM).
  • - This dashboard allows users to visualize important quality data through various formats like histograms, pie charts, and tables.
  • - Future plans include adding more quality indicators to the dashboard and assessing feedback from clinicians on its usefulness.
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  • - This study evaluates how well the OMOP common data model standardizes Continuous Renal Replacement Therapy (CRRT) data from ICU patients in two French hospitals.
  • - Researchers successfully extracted and transformed data from 1,696 ICU stays into the OMOP format, aligning 46 standard concepts related to CRRT, despite facing issues with data variability.
  • - The findings indicate that while the OMOP model shows promise for harmonizing ICU data, further improvements are needed to enhance clinical decision-making and patient outcomes in critical care.
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  • The study focuses on the rising aging population in France and Western Europe, specifically individuals aged 85 and older, and their mortality risk in trauma centers' ICUs.
  • Conducted from 2013 to 2022, the research analyzed 365 severely injured older patients in 14 ICU trauma centers, assessing their frailty and other clinical variables.
  • High mortality rates were found, with 43.5% in the ICU and 45.5% at 30 days, linked to factors like traumatic brain injury and severe hemorrhage, highlighting the need for early geriatric interventions to improve patient outcomes.
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[Methemoglobinemia].

Rev Med Interne

August 2024

Methemoglobinemia (MetHb) refers to the state of oxidation of the iron ion "ferrous" (Fe to iron "ferric" (Fe) within the heme molecule that makes up hemoglobin (Hb). This state is physiological if its level remains controlled. The ferrous state of the heme molecule occurs in the event of significant oxidative stress.

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Randomized controlled trials have shown a higher risk of postoperative hypoxemia and delayed extubation with opioid-free anesthesia (OFA), compared with opioid anesthesia. The practice of OFA is not standardized. The objective of this study is to investigate the association between the dexmedetomidine administration protocol used and the occurrence of postoperative respiratory complications.

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Background: With the generalization of social network use by health care workers, we observe the emergence of breaches in medical confidentiality. Our objective was to determine, among anesthesiology and intensive care health care workers, the rate of medical confidentiality breaches among professional tweets.

Methods: We performed a retrospective analysis of public Twitter data available through the official Twitter application program interface.

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Background: Postoperative pain after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is important. It appears essential to reduce postoperative pain and morphine consumption.

Methods: Retrospective study in a university hospital comparing patient benefiting from CRS-HIPEC under opioid-free anesthesia (OFA; dexmedetomidine) to those anesthetized with opioid anesthesia (OA; remifentanil) using a propensity score matching method.

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Article Synopsis
  • * The primary goal is to standardize the process and transformations involved in feature extraction, including storage solutions within a data warehouse framework.
  • * Results from interviews with researchers identified two key concepts, "track" and "feature," and proposed the creation of "TRACK" and "FEATURE" tables for better organization of extracted data.
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Purpose: Intensive care medicine (ICM) has the particularity of being a multidisciplinary specialty and its literature reflects this multidisciplinarity. However, the proportion of each field in this literature and its trend dynamics are not known. The objective of this study was to analyze the ICM literature, extract latent topics and search for the presence of research trends.

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Background: Electronic health records (EHRs, such as those created by an anesthesia management system) generate a large amount of data that can notably be reused for clinical audits and scientific research. The sharing of these data and tools is generally affected by the lack of system interoperability. To overcome these issues, Observational Health Data Sciences and Informatics (OHDSI) developed the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) to standardize EHR data and promote large-scale observational and longitudinal research.

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Background And Importance: Hyperoxemia may be associated with increased mortality in emergency room or ICU patients. However, its effect during septic shock is still debated.

Objective: To evaluate the effect of hyperoxemia on ICU mortality, during the first 24 h of ICU stay, in mechanically ventilated patients with septic shock according to SEPSIS-3 criteria.

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Background: Critical care teams are on the front line of managing the COVID-19 pandemic, which is stressful for members of these teams.

Objective: Our objective was to assess whether the use of social networks is associated with increased anxiety related to the COVID-19 pandemic among members of critical care teams.

Methods: We distributed a web-based survey to physicians, residents, registered and auxiliary nurses, and nurse anesthetists providing critical care (anesthesiology, intensive care, or emergency medicine) in several French hospitals.

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Background: Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicrobial therapy might however, also negatively impact the prognosis.

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Article Synopsis
  • VA-ECMO is used to assist patients in cardiogenic shock, but excessive fluid intake can lead to harmful overload.
  • A study of 101 patients from 2013-2016 found a 47.5% mortality rate, with non-survivors showing significantly higher fluid-balance on days one and two.
  • Early positive fluid-balance correlates with increased mortality risk, highlighting a critical threshold of 38.8 mL/kg as a predictor for adverse outcomes.
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