Publications by authors named "Popa Alexandru"

() infection is a widespread global health issue and a primary cause of diseases like gastritis, gastroduodenal ulcers, and gastric cancer. This study examines the prevalence of infection in patients undergoing upper endoscopy and assesses the efficacy of bismuth quadruple therapy (BQT) and levofloxacin triple therapy. A retrospective analysis of 507 gastroscopies was conducted, with indications including epigastric pain, heartburn, postprandial fullness, early satiation, and regurgitation.

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The mesoporous silica KIT-6 was synthesized and functionalized with 3-aminopropyltriethoxysilane (APTES) by grafting at 110 °C. The composites were prepared with three different concentrations of APTES: 20, 30 and 40 wt.%.

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Background And Objectives: Diminutive polyps present a unique challenge in colorectal cancer (CRC) prevention strategies. This study aims to assess the characteristics and variables of diminutive polyps in a Romanian cohort, intending to develop a combined resect-and-retrieve or resect-and-discard strategy that reduces the need for an optical diagnosis.

Materials And Methods: A prospective cohort study was conducted at two endoscopy centers in Romania from July to December 2021.

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Laparoscopic cholecystectomy (LC) is the gold standard treatment in acute cholecystitis. However, one in six cases is expected to be difficult due to intense inflammation and suspected adherence to and involvement of adjacent important structures, which may predispose patients to higher risk of vascular and biliary injuries. In this study, we aimed to identify the preoperative parameters with predictive value for surgical difficulties.

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Bismuth oxides were synthesized from bismuth carbonate using the sol-gel method. Studies have described the formation of BiO, as a precursor of HNO dissolution, and intermediate oxides, such as BiO when using HSO and HPO. The average size of the crystallite calculated from Scherrer's formula ranged from 9 to 19 nm, according to X-ray diffraction.

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Cystic echinococcosis is an often-overlooked condition that otherwise negatively impacts both the individual and the community, prompting major public health concerns. Early diagnosis and treatment, as well as collaboration between specialties including surgery and parasitology, are essential for avoiding complications and disease relapse. To better illustrate this, we present the case of an elderly person with a rare localization of the disease at the muscular level.

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Vibration-controlled transient elastography (VCTE) was the first non-invasive method used for assessing liver fibrosis in patients with chronic liver disease. Over the years, many studies have evaluated its performance. It is now used globally, and, in some countries, it represents the primary step in evaluating liver fibrosis.

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The ordered mesoporous silica MCM-48 with cubic Ia3d structure was synthesized using the cationic surfactant hexadecyltrimethylammonium bromide (CTAB) as a template agent and tetraethylorthosilicate (TEOS) as a silica source. The obtained material was first functionalized with (3-glycidyloxypropyl)trimethoxysilane (KH560); further, two types of amination reagents were used: ethylene diamine (N2) and diethylene triamine (N3). The modified amino-functionalized materials were characterized by powder X-ray diffraction (XRD) at low angles, infrared spectroscopy (FT-IR) and nitrogen adsorption-desorption experiments at 77 K.

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Objective: Although intake of specific macronutrients has been associated with sleep parameters, interventional evidence is lacking. Therefore, this randomized trial was conducted to examine how a more unhealthy high-fat/high-sugar (HFHS) diet impacts sleep in humans.

Methods: In a crossover study, 15 healthy young men consumed two isocaloric diets in random order for a week: an HFHS and a low-fat/low-sugar diet.

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Adsorption recovery of precious metals on a variety of solid substrates has steadily gained increased attention in recent years. Special attention was paid to the studies on the characterization of the adsorptive properties of materials with a high affinity for gold depending on the nature of the pendant groups present in the structure of the material. The aim of the present work was to synthesize and characterize a new material by using the sol-gel synthesis method (designated as BCb/CB).

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  • The study investigates the effectiveness of two biomarkers, Cytokeratin 19 (CK19) and Glypican-3 (GPC3), for predicting hepatocellular carcinoma (HCC) in cirrhosis patients, comparing them to the widely used GALAD score and other biomarkers like alpha-fetoprotein (AFP) and des-g-carboxyprothrombin (DCP).
  • A total of 154 participants were analyzed—95 with confirmed HCC and 59 without—using statistical methods to develop the GALKA score, which included multiple biomarkers and assessed their predictive capabilities for HCC.
  • The findings showed that AFP was the most effective biomarker, while G
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  • The study explores the use of ultrasound 2D shear-wave elastography (SWE) and shear-wave dispersion (SWD) to measure viscosity and diagnose chronic autoimmune thyroiditis (CAT) in patients compared to healthy individuals.
  • A total of 308 cases were analyzed, finding significant differences in viscosity and shear-wave speed between the CAT group and the healthy group, indicating potential diagnostic importance.
  • Although 2D-SWE PLUS showed good diagnostic performance, the Vi PLUS method alone had poor performance; however, both methods correlated with various factors such as thyroid volume and age, and provided complementary information for a more thorough assessment of thyroid conditions.
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  • Non-invasive tests, including liver elastography and biological scores, were utilized to evaluate liver disease severity in patients with alcohol use disorder (AUD).
  • In a study of 172 AUD patients, around 17.5% were found to have liver cirrhosis and 70.9% had moderate to severe liver steatosis.
  • Significant correlations were observed between liver stiffness and various biological scores, with the age-platelet index showing superior predictive ability for advanced fibrosis compared to other markers.
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This is a retrospective single-center study that included 87 subjects. All subjects had chronic hepatitis B or HBV cirrhosis and underwent nucleos(t)ide analogs (NUC) treatment for more than one year. The study aimed to evaluate the dynamic changes in liver stiffness (LS) measured by transient elastography (TE) during a median interval of 64 months.

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  • This study focuses on the use of non-invasive ultrasound techniques to measure kidney elasticity and viscosity, as there is limited existing data on these metrics.
  • A cross-sectional analysis involved 50 participants, where various demographic and health factors were correlated with their kidney stiffness and viscosity measurements using advanced ultrasound technology.
  • Results showed that age and estimated glomerular filtration rate (eGFR) significantly influenced kidney elasticity and viscosity, while body mass index (BMI) had a lesser effect, highlighting the need for further research in this area.
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Shear-wave elastography (SWE) is widely used in thyroid evaluation, but multiple factors influence thyroid stiffness. Estimating tissue viscosity may enhance the ultrasound diagnosis of thyroid diseases, along with the ultrasound (US) and the SWE assessment. In order to be able to detect diffuse thyroid disease by viscosity measurements, it is essential to firstly define the normal values of thyroid viscosity in healthy subjects.

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Liver fibrosis is the most significant prognostic factor in chronic liver disease (CLD). Clinical practice guidelines recommend the use of non-invasive techniques, such as two-dimensional shear-wave elastography (2D-SWE), to assess liver stiffness as a marker of fibrosis. Several other factors influence liver stiffness in addition to liver fibrosis.

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The hormone fibroblast growth factor 21 (FGF21) modulates tissue metabolism and circulates at higher levels in metabolic conditions associated with chronic sleep-wake disruption, such as type 2 diabetes and obesity. In the present study, we investigated whether acute sleep loss impacts circulating levels of FGF21 and tissue-specific production, and response pathways linked to FGF21. A total of 15 healthy normal-weight young men participated in a randomised crossover study with two conditions, sleep loss versus an 8.

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. This study aimed to evaluate the performance of four ultrasound-based techniques for the non-invasive multiparametric (MPUS) assessment of liver fibrosis (LF), steatosis (HS), and inflammation in patients with NAFLD. We included 215 consecutive adult patients with NAFLD (mean age: 54.

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The goal of this study was to evaluate the performance of two new ultrasound-based techniques (ShearWave PLUS elastography [2-D-SWE PLUS], SSp PLUS Imaging [SSp PLUS]) implemented on the Aixplorer Mach 30 ultrasound system (Supersonic Imagine, Aix-en-Provence, France) for the non-invasive assessment of liver steatosis and fibrosis, using transient elastography (TE) with the controlled attenuation parameter (CAP) as reference. This monocentric cross-sectional study included 133 consecutive adult patients with chronic hepatopathies. Liver stiffness and steatosis were evaluated in the same session using the techniques mentioned above.

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Aim: This study aimed to evaluate the diagnosis performance of time-harmonic elastography (THE) technique in real life in assessing liver fibrosis, considering vibration-controlled transient elastography (VCTE) as a reference method.

Material And Method: We prospectively evaluated outpatients from the gastroenterology department. Liver stiffness (LS) was measured by the THE system by dedicated operators, and by VCTE by experienced operators.

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Objective: The aim of this study is to verify if the experience on 4 years in using minimally invasive techniques in the treatment of CE could match regarding the indications and results with the major studies on topic.

Method: During 03.2014 - 03.

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  • Cystic echinococcosis is a neglected zoonotic infection recognized by WHO, with this study focusing on its prevalence in rural Bulgaria, Romania, and Turkey.
  • The research involved a cross-sectional survey using ultrasound screening across 50 villages, resulting in over 24,600 individuals being screened for the disease.
  • The findings showed a low but present prevalence of abdominal cystic echinococcosis, with rates of 0.41% in Bulgaria and Romania, and 0.59% in Turkey, affecting individuals of all ages in different provinces.
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Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a.

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