Exploring the antimitotic, thrombolytic, and cytotoxic properties of lasiosiphon glaucus or gnidia glauca (fresen.) gilg leaf alkaloid extract: insights from experimental and in silico investigations.

Plant alkaloids are nitrogen containing secondary metabolites that have wide range of biological properties including anticancer activity. ' or ' (Fresen.) Gilg,' known for its biological properties, requires exploration to evaluate cytotoxic and anticancer effects.

Multifaceted Anticancer Potential of (Fresen.) Gilg Leaf Alkaloids: Impact on Multiple Cellular Targets.

(Fresen.) Gilg has demonstrated significant anticancer potential through multiple mechanisms, including apoptosis induction, as shown by the TUNEL assay against MCF-7 cells, modulation of tubulin polymerization, preservation of mitochondrial function indicated by the JC-1 assay, and inhibition of DNA polymerase α and β activities. Rationale for the present study is to investigate the potential anticancer properties of leaf alkaloid extract.