Assessment of lapachol's anti-inflammatory effectiveness in mitigating sepsis-induced acute lung injury.

Sepsis-induced Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) pose life-threatening risks due to an excessive activation of proinflammatory cytokines via the JAK pathway. Currently, no confirmed drug treatment exists for ALI. In this study, we explored JAK1 as a potential therapeutic target to address this issue.

Exploring the pharmacological and chemical aspects of pyrrolo-quinazoline derivatives in .

is one of the biggest and complex genera of the Acanthaceae family. is commonly known as 'Adosa'. It is an ayurvedic medicine with a medicinal history of more than a thousand years in India.

Study of potent CDK7 inhibitor secondary metabolites from .

Chemical investigation of the petroleum ether extract of heartwood of led to the isolation of tectonaquinone B (1), 2-methylquinizarin (2) along with tecomaquinone I (3), lapachol (4), 2-isopropenylnaphtho[2,3-b]-furan-4,9-quinone (5), dehydro-α-lapachone (6), α-lapachone (7), and β-lapachone (8). This is the first report of isolation of tectonaquinone B and 2-methylquinizarin from this plant. The structures of compounds were elucidated by advanced spectroscopic methods.

A review on phytochemical constituents and pharmacological potential of .

is locally known as or in Hindi, milk weed in English and belongs to the family Apocynaceae and subfamily Asclepiadoideae. Although a wasteland plant, it is of sacred use as its flowers are offered for worshipping Lord Shiva, a Hindu God. Tribes all over the world use the plant in treatment of various diseases like snake bite, body pain, asthma, epilepsy, cancer, sexual disorders, skin diseases and many more.

Tectonaquinones A, B and C: three new naphthoquinone derivatives from the heartwood of .

Chemical investigation of the chloroform extract of heartwood of L. f. led to the isolation of three new naphthoquinone derivatives, tectonaquinones A (), B () and C (), along with six known compounds: barleriaquinone-I (), tectoquinone (), tecomaquinone I (), lapachol (), obtusifolin () and 2-hydroxy-3-methyl anthraquinone ().

Facile Synthesis of Naphtha-quinoxaline Derivatives from β-lapachone Using Graphene Oxide as Catalyst.

Objective: To develop efficient method for the synthesis of naphtha-quinoxaline derivatives via the reaction of β-lapachone with various 1,2-diamines.

Methods: A mixture of β-lapachone (1mmol), 1,2-diamine (1mmol) and graphene oxide (20mg) in methanol (3mL) was heated at 60°C, under constant stirring for appropriate time. After completion of the reaction, the catalyst was filtered off, washed with ethyl acetate (3x3mL) and the combined filtrate was washed with H2O, dried (anhy.

(teak) - A review on its phytochemical and therapeutic potential.

Linn (Teak), is locally known as Sagwan, belongs to Lamiaceae family. It is one of the most valuable timber in the world, due to its beautiful surface and its resistance to termite and fungal damage. The main active ingredient compounds that are responsible for these action are tectoquinone, lapachol and deoxylapachol.