Publications by authors named "Poon E"

Sprint interval training (SIT) is a potent exercise strategy to enhance athletes' aerobic capacity in a time-efficient manner. The purpose of this study was to examine the effect of a low-volume court-based SIT program on aerobic capacity and sport-specific endurance performance for competitive tennis players. Sixteen competitive collegiate tennis players were randomly assigned to the SIT (court-based repeated-sprint training) and traditional endurance training (ET; 45-min continuous treadmill running) groups for a 6-week intervention (3 sessions/week).

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The importance of extra-nodal disease has been well recognized in follicular lymphoma, and is incorporated into various prognostic tools. However, the optimal treatment strategy for this subgroup remains unclear. In this multicenter retrospective study, we analyzed 143 patients who received either R-CHOP or Bendamustine-Rituximab (BR), with a median follow-up of 69.

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A four-dimensional phase-contrast magnetic resonance imaging sequence with respiratory-controlled adaptive k-space reordering (ReCAR-4DPC) offers potential benefits of improved scan efficiency and motion robustness. The purpose of this study was to evaluate the reproducibility of flow measurement using this technique and to compare hemodynamic metrics obtained to two-dimensional phase contrast MRI (2DPC)-derived metrics of the thoracic aorta. ReCAR-4DPC was performed with identical scan parameters in 15 healthy volunteers (6M,9F, mean [range] 37 [23-47] years) and 11 patients with thoracic aortic dissection (6M,5F, 56 [31-81] years) and acquisition time was recorded.

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Purpose: The present study evaluates the preliminary effectiveness of a parent-implemented support program to enhance language outcomes in Chinese-learning preschoolers with a confirmed diagnosis or at elevated likelihood of autism, a lifelong neurodevelopmental condition. The program is delivered entirely online with the option of a group format. Because of cross-cultural differences in adult learning and parent-child interaction and because parent coaching programs for autism that are delivered online are only emerging, a specific study to evaluate the effectiveness of online support for Chinese families is warranted.

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Background: Physical fitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health. However, inconsistencies in tests and protocols limit international monitoring and surveillance. The objective of the study was to seek international consensus on a proposed, evidence-informed, Youth Fitness International Test (YFIT) battery and protocols for health monitoring and surveillance in children and adolescents aged 6-18 years.

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High-intensity interval training (HIIT) is an emerging exercise strategy to improve health and fitness, but previous studies have evaluated HIIT interventions across different populations and outcomes. This review aimed to comprehensively synthesize published evidence on the effects of HIIT on key cardiometabolic health parameters in children and adolescents. We searched seven databases until February 2024.

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Context: Recent studies suggest that light-intensity physical activity may enhance cardiometabolic health and reduce mortality risk in adults. However, more information is required to understand the patterns of light-intensity physical activity and postprandial cardiometabolic health.

Objective: This study examined the effects of different light-intensity walking patterns on postprandial cardiometabolic responses in young obese adults.

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The strength of a systematic review hinges in large part on the quality of evidence it appraises. Observational studies, including cohort studies and case series, are positioned lower on the hierarchy of evidence, with cohort studies typically higher than case series. The often subtle differences between these study designs may lead to misclassification and can impact the strength of recommendations derived from such data.

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Parrots produce stunning plumage colors through unique pigments called psittacofulvins. However, the mechanism underlying their ability to generate a spectrum of vibrant yellows, reds, and greens remains enigmatic. We uncover a unifying chemical basis for a wide range of parrot plumage colors, which result from the selective deposition of red aldehyde- and yellow carboxyl-containing psittacofulvin molecules in developing feathers.

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Background: The most common aggressive lymphoma in adults is diffuse large B-cell lymphoma (DLBCL). Consolidative radiotherapy (RT) is often administered to DLBCL patients but guidelines remain unclear, which could lead to unnecessary RT. We aimed to evaluate the value of end-of-treatment PET-CT scans, interpreted using the Deauville score (DV), to guide the utilization of consolidative RT, which may help spare low-risk DLBCL patients from unnecessary RT.

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Studies of widely distributed species can inform our understanding of how past demographic events tied to historic glaciation and ongoing population genetic processes interact to shape contemporaneous patterns of biodiversity at a continental scale. In this study, we used whole-genome resequencing to investigate the current population structure and genetic signatures of past demographic events in the widespread migratory American goldfinch (Spinus tristis). Phylogenetic relationships inferred from whole mitochondrial genomes were poorly resolved.

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Article Synopsis
  • The FDA regulates medical devices to make sure they are safe and work well before they can be sold.
  • A survey was done to understand how the FDA's Medical Devices Advisory Committee makes decisions and what could be improved.
  • Out of 92 panel members, most were men and white, and many thought the information from the FDA was fair and that important trials were often designed well.
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  • About 50% of neuroblastomas with poor prognosis are linked to the over-expression of the MYCN protein, and previous research has shown that targeting PRMT5 leads to cell death in these cases.
  • The study evaluates GSK3203591, a new PRMT5 inhibitor, showing that it inhibits MYCN-dependent growth and triggers changes in gene expression and mRNA splicing in MNA neuroblastoma cells, particularly affecting glutamine metabolism.
  • In tests on mice, the related compound GSK3326593 demonstrated increased survival, confirming that both drugs exploit PRMT5's role in splicing and regulation of metabolic pathways in MYCN-amplified neuroblastomas.
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  • A study was conducted to analyze how often dermatologic surgeons face challenges in identifying the locations of skin cancer tumors before surgery.
  • Out of over 17,000 cases, only 0.60% involved uncertain sites, with these cases more common in older, male patients who had biopsies done over a month prior.
  • Surgeons commonly used various methods to confirm tumor locations, achieving success in identifying 82% of these uncertain sites, while some surgeries were delayed, especially for non-facial tumors.
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Radiological incidental findings (IFs) are previously undetected abnormalities which are unrelated to the original indication for imaging and are unexpectedly discovered. In brain magnetic resonance imaging (MRI), the prevalence of IFs is increasing. By reviewing the literature on IFs in brain MRI performed for research purposes and discussing ethical considerations of IFs, this paper provides an overview of brain IF research results and factors contributing to inconsistencies and considers how the consent process can be improved from an ethical perspective.

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  • Congenital cytomegalovirus (cCMV) is a common viral infection in newborns, with maternal CMV serology tests typically starting with IgM and IgG antibody assessment.
  • In a study of five perinatal cases, cCMV was diagnosed in fetuses despite negative maternal IgM results during the second trimester, highlighting the limitations of this test.
  • The findings suggest that a negative maternal CMV IgM does not rule out cCMV, making prenatal CMV testing important along with autopsy and placental evaluations for unexplained fetal issues.
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  • - The study aimed to determine if high-intensity interval training (HIIT) is more effective than moderate-intensity continuous training (MICT) or no exercise for improving components of metabolic syndrome (MetS) in affected individuals.
  • - A systematic review analyzed 23 randomized controlled trials (RCTs) with 1374 participants, finding that HIIT significantly improved various health metrics like waist circumference, blood pressure, cholesterol levels, triglycerides, and blood glucose compared to non-exercise control.
  • - The results suggest that HIIT is a beneficial exercise option for enhancing cardiometabolic health, with low-volume HIIT being as effective as higher-volume workouts, making it a practical alternative to traditional aerobic exercise.
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  • * A study tested 516 pet birds in Hong Kong, discovering that 0.97% were infected with C. psittaci, mostly from pet shops, highlighting potential sources of transmission.
  • * Genetic analysis showed that all strains identified belonged to Genotype A and were similar to those found in various other species and locations, confirming the presence of this zoonotic pathogen in captive birds and the risks it poses to humans and wildlife.
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  • Most HDAC inhibitors are non-selective and cytotoxic, limiting their use in chronic inflammatory diseases, whereas selective class IIa HDAC inhibitors like LL87 may offer safer alternatives.
  • LL87 showed significant selectivity for class IIa HDACs and exhibited low cytotoxicity in macrophages, reducing inflammation by inhibiting cytokine secretion.
  • In a rat model of arthritis, LL87 effectively decreased joint swelling, immune cell infiltration, and tissue damage, marking it as a promising candidate for managing chronic inflammatory conditions.
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Carbohydrate (CHO) and caffeine (CAF) mouth rinsing have been independently reported to benefit sport performance. The proposed mechanisms by which mouth rinsing CHO exerts an influence are reported to be different from those for mouth rinsing CAF. However, the potential ergogenic effects of combining CHO and CAF in a single mouth rinse solution, are unclear.

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Sprint interval training (SIT) is a potent exercise strategy to enhance athletes' anaerobic capacity in a time-efficient manner. This study aimed to investigate the impact of low-volume, court-based SIT on the anaerobic capacity and sport-specific performance in competitive tennis players. Twenty-four competitive collegiate tennis players were randomly assigned to either the SIT group (n = 12; three sessions per week of court-based repeated-sprint training) or the traditional endurance training (ET) group (n = 12; three sessions per week of 45-min continuous treadmill running, n = 12) for a 6-weeks intervention.

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A surge of public interest in NMN supplementation has been observed in recent years. However, whether NMN supplements are effective in improving metabolic health remains unclear. The objective of the review was to assess the effects of NMN supplementation on fasting glucose, triglycerides, total cholesterol, LDL-C, and HDL-C in adults.

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  • COVID-19 can lead to heart issues, and different SARS-CoV-2 variants vary in how they impact heart cells (cardiomyocytes).
  • The study examined the effects of these variants using human heart cells grown in labs and tested them in Golden Syrian hamsters, revealing that the Omicron BA.2 variant had the most significant harmful effects on heart cells.
  • Findings indicate that Omicron BA.2 infects heart cells through a unique process and causes changes that could lead to heart dysfunction, suggesting that even variants seen as mild can pose serious risks for cardiac health and warrant further research.
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Background: Feeding problems in children with autism jeopardize the well-being of both children with autism and their families. Mixed findings were reported from previous interventions, which were mostly evaluated by single subject research design (SSRD) studies. Moreover, feasibility assessment and social validity measurement were unaddressed by these SSRD studies.

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Background: Although the efficacy of interval training for improving body composition has been summarized in an increasing number of systematic reviews in recent years, discrepancies in review findings and conclusions have been observed.

Objective: This study aims to synthesize the available evidence on the efficacy of interval training compared with moderate-intensity continuous training (MICT) and nonexercise control (CON) in reducing body adiposity in apparently healthy adults.

Methods: An umbrella review with meta-analysis was performed.

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