Publications by authors named "Poon C"

CO mineralization, a process where CO reacts with minerals to form stable carbonates, presents a sustainable approach for CO sequestration and mitigation of global warming. While the crucial role of water in regulating CO mineralization efficiency is widely acknowledged, a comprehensive understanding of the underlying mechanisms remains elusive. This study employs a combined experimental and atomistic simulation approach to elucidate the intricate mechanisms governing moisture-driven carbonation kinetics of calcium-bearing minerals.

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The feasibility of carbon mineralization relies on the carbonation efficiency of CO-reactive minerals, which is largely governed by the water content and state within material mesopores. Yet, the pivotal role of confined water in regulating carbonation efficiency at the nanoscale is not well understood. Here, we show that the maximum CO intake occurs at an optimal relative humidity (RH) when capillary condensation initiates within the hydrophilic mesopores.

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Fabricating transition metal selenide (TMSe) anode materials with rapid K diffusion and high-rate performance is crucial for the advancement of potassium-ion batteries (PIBs), yet it remains a challenge. In this study, a Cu-doped CoSe@N-doped carbon anode with an optimal concentration of Cu-doped and yolk-shell structure (denoted as Cu-CoSe@NC-2) is developed to enhance the reaction kinetics and cycling life. The Cu-doped modulates the electronic structure of the CoSe interface, improves the diffusion and adsorption of K, and further promotes the charge transport efficiency, as demonstrated by theoretical calculations and experimental results.

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Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol.

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The poor alkali resistance of nano-glassy fiber (NGF) hinders its application in aggressive alkaline environments like cement and alkaline wastewater. This study introduced a potential strategy to enhance the alkali resistance of NGF based on the distinct atomic-scale interactions between CO molecules and NGF ions at high temperatures. The short-range structure in the NGF-CO system was elucidated through the pair distribution functions and coordination numbers of ion-oxygen pairs and second-nearest-neighbor ion-ion pairs.

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Article Synopsis
  • * The proposed design involves impregnating concrete with a silane-water system and injecting CO2, leading to the formation of micro-nano structures that achieve a high contact angle of 171.9° without compromising concrete strength.
  • * This innovative three-layer structure provides effective waterproofing against various environmental stresses and captures CO2 during the process, offering sustainable solutions for concrete applications.
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This study examined the longer-term individual- and school-level changes in students 7 months after a 1-hour delay in school start time (SST). Two cohorts of grade 11 students (N = 227; 60.8% female, age = 17.

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Background And Purpose: Icariin, an 8-prenylated flavonoid glycoside, is an anabolic agent that could exert rapid estrogenic actions via ligand-independent activation of estrogen receptor alpha (ERα) in osteoblastic cells to promote osteogenesis. However, relatively little is known about its direct cellular target, its protective effects, and cell adhesion activities in bone marrow stromal cells (BMSCs) against microgravity. In the present study, the effects of icariin on osteogenesis and cell adhesion under microgravity were examined with the involvement of integrin receptor α5β1, connexin 43, and CAMs.

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Objectives: The aim of this study was to present key technologic and regulatory milestones in spinal cord stimulation (SCS) for managing chronic pain on a narrative timeline with visual representation, relying on original sources to the extent possible.

Materials And Methods: We identified technical advances in SCS that facilitated and enhanced treatment on the basis of scientific publications and approvals from the United States (US) Food and Drug Administration (FDA). We presented milestones limited to first use in key indications and in the context of new technology validation.

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Background: Stem cell-based transplantation therapy holds promise for peripheral nerve injury treatment, but adult availability is limited. A cell culture protocol utilizing a small-molecule cocktail effectively reprogrammed stem cells from apical papilla (SCAPs) into neural progenitor cells, subsequently differentiating into neuron-like cells. This study aims to evaluate neural-induced SCAPs, with and without small-molecule cocktail, for sciatic nerve repair potential.

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Article Synopsis
  • The rise of omic data brings new challenges in how we handle, analyze, and integrate this information, which is crucial for biological research.
  • Bioconductor serves as a comprehensive platform for community-driven analysis of biological data, while tidy R programming introduces an innovative approach for organizing and manipulating data.
  • The tidyomics software ecosystem connects Bioconductor with tidy R practices, aiming to simplify omic analysis and facilitate collaboration across different scientific disciplines, as evidenced by its successful application in analyzing a large dataset from the Human Cell Atlas.
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Background: Disrupted sleep and rest-activity pattern are common clinical features in depressed individuals. This meta-analysis compared sleep and circadian rest-activity rhythms in people with major depressive disorder (MDD) or depressive symptoms and healthy controls.

Methods: Eligible studies were identified in five databases up to December 2023.

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Super sulfate cement (SSC) emerges as a sustainable alternative to ordinary Portland cement, boasting minimal carbon emissions and exceptional performance. As the quest for eco-friendly alternatives intensifies, there's a growing focus on exploring alkaline and sulfate activators conducive to SSC's environmental goals. This study delves into the viability of utilizing MgO as an alkaline activator in producing MgO-based supersulfated cement, while also investigating the impact of various industrial by-product gypsums on its performance.

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Article Synopsis
  • - The increasing amount of omic data creates challenges in how to manage, analyze, and integrate this information.
  • - Bioconductor offers a community-driven platform for biological data analysis, while tidy R programming introduces a new standard for organizing and manipulating data.
  • - This software ecosystem connects Bioconductor with tidy R, aiming to simplify omic analysis and foster collaborations, demonstrated through the analysis of 7.5 million cells from the Human Cell Atlas.
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Municipal solid waste incineration fly ash (IFA) designated as hazardous waste poses risks to environment and human health. This study introduces a novel approach for the stabilization and solidification (S/S) of IFA: a combined approach involving alkali treatment and immobilization in low-carbon supersulfated cement (SSC). The impact of varying temperatures of alkali solution on the chemical and mineralogical compositions, as well as the pozzolanic reactivity of IFA, and the removal efficiency of heavy metals and metallic aluminum (Al) were examined.

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  • Chronic kidney diseases like ADPKD have limited treatment options, and existing drugs often have low effectiveness and side effects when delivered through traditional methods.
  • Researchers have developed a new approach using chitosan particles to orally deliver kidney-targeting peptide micelles, which improves drug bioavailability and absorption in the intestines.
  • In tests on mice with ADPKD, this new method showed better therapeutic results and safety compared to previous delivery systems, suggesting it could be a promising solution for long-term kidney disease treatment.
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  • - Human fishing practices pose significant risks to marine ecosystems, threatening coastal cetaceans like dolphins and porpoises through ingestion of fishing gear and bycatch.
  • - A case study on Jeju Island highlighted an Indo-Pacific finless porpoise that ingested fishing hooks and suffered from severe Anisakis infection, illustrating the direct consequences of fishing on marine life.
  • - The study calls for urgent action to mitigate the negative impacts of fishing activities on marine mammals and emphasizes the need for further research on the distribution and health of coastal cetaceans in Korean waters.
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Objectives: The aim of this study was to present key findings from the 2019 national adult oral health survey in Singapore (NAOHS).

Methods: A multi-stage stratified sampling method was used to recruit participants for a representative national adult oral health survey. A total of 12 212 households were randomly selected from the National Database on Dwellings in Singapore.

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Article Synopsis
  • Ubiquitin modifications play a crucial role in altering protein function and stability, impacting cell survival, especially during stress like ischemic stroke.
  • In a study using a proteomics approach on mice, researchers identified 198 proteins that were ubiquitinated post-stroke, many of which are vital for the structure of glutamatergic neurons' postsynaptic density (PSD).
  • The study revealed that ubiquitination affects kinase activities associated with neuronal cell injury, with specific kinases showing altered activities after stroke; removing ubiquitin reversed these changes, highlighting its critical role in regulating kinases during ischemic injury.
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Oleanolic acid (OA) is previously shown to exert bone protective effects in aged animals. However, its role in regulating osteoblastic vitamin D bioactivation, which is one of major causes of age-related bone loss, remains unclear. Our results revealed that treatment of OA significantly increased skeletal CYP27B1 expression and circulating 1,25(OH)D in ovariectomized mice (p <0.

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Article Synopsis
  • Spinal deformities like kyphoscoliosis are frequently observed in cetaceans, particularly bottlenose dolphins, but information on their occurrence in narrow-ridged finless porpoises (NFP) is scarce.
  • In November 2021, two dead NFPs were found in South Korea, and post-mortem computed tomography (PMCT) revealed they had congenital and degenerative forms of kyphoscoliosis.
  • The study suggests that while kyphoscoliosis may not have directly caused their deaths, it likely limited their spinal movement and mobility, which could have contributed to their demise, marking a significant documentation in understanding NFP health.
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Objectives: Prevention complements the curative management of oral diseases. Effective preventive interventions involve the adoption of oral health promoting behaviours. Little is known about the awareness of oral disease and its prevention among Singaporean adults as well as their prevailing oral health attitudes and behaviours.

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Objective: Sleep and circadian disturbance is highly comorbid with a range of psychological disorders, especially major depressive disorder (MDD). In view of the complexity of sleep and circadian problems in MDD, this study aimed to evaluate the efficacy of a group-based transdiagnostic intervention for sleep and circadian dysfunction (TranS-C) for improving depressive symptoms and sleep and circadian functions.

Method: One hundred fifty-two adults diagnosed with comorbid MDD and sleep and circadian dysfunctions were randomized into TranS-C group treatment (TranS-C; = 77) or care as usual (CAU; = 75) control group.

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Previous research has suggested that individuals with major depressive disorder (MDD) experienced alterations in sleep and activity levels. However, the temporal associations among sleep, activity levels, mood, and daytime symptoms in MDD have not been fully investigated. The present study aimed to fill this gap by utilizing real-time data collected across time points and days.

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