Systems biology approach: identification of hub genes, signaling pathways, and molecular docking of COL1A1 gene in cervical insufficiency.

The collagen type I alpha 1 COL1A1, OMIM #120,150) gene, encoding the alpha-1 chain of type I collagen (UniProt #P02452), plays a key role in life-homeostasis due to its remarkable involvement in collagen synthesis. It is a promising candidate gene implicated in the pathogenesis of cervical insufficiency (CI). This study aimed to identify genetic variations within the COL1A1 gene that contribute to the development of CI.

A Highly Selective Pyrene Appended Oxacalixarene Receptor for MNA and 4-NP Detection: an Experimental and Computational Study.

A novel pyrene-substituted oxacalixarene was designed and synthesized as a selective probe for the simultaneous detection of MNA and 4-NP. Utilizing 1H-NMR, 13C-NMR, and FT-IR analysis techniques, its structure was characterized. The binding property of BPOC to a variety of NACs, including 1,3-DNB, 2,3-DNT, 2,4-DNT, 2,6-DNT, 4-NP, 4-NT, and PA, revealed that the sensor binds to MNA and 4-NP with remarkable selectivity.

Gold nanoparticles synthesis using Gymnosporia montana L. and its biological profile: a pioneer report.

Background: The forming, blending, and characterization of materials at a size of one billionth of a meter or less is referred to as nanotechnology. The objective of the current study was to synthesize ecologically friendly gold nanoparticles (AuNPs) from Gymnosporia montana L. (G.

Light-cured calcium hydroxide cements release of calcium ions using argon based induction coupled mass spectroscopy - an study.

Calcium ion-releasing ability of different calcium hydroxide-based pulp capping materials was comparatively evaluated in this study. Different brands of cements were taken from different manufacturers and categorized into three groups. Three different brands of Ca(OH) cements (Dycal, TheraCal, and Cal LC) were taken prepared by mixing and curing the cements as per the manufacturer's instructions.

Effect of different burs on the topography of smear layer formation on the dentinal surface: a scanning electron microscope study.

Whenever a hand or a rotary instrument is used to eliminate tooth tissue, the mineralized matrix shatters rather then being uniformly sheared, producing considerably quantities of cutting debris. Much of the debris made up of very small particles of mineralized collagen matrix over the surface of dentin is known as smear layer. The clinical outcome of dental restorations is dependent upon the surface preparations, smear layer formation and hybrid layer which which provides a stable adhesion.