Publications by authors named "Pooja S Rajaput"
Article Synopsis
- Pancreatic cancer has a very low 5-year survival rate of less than 5%, and the current treatment, gemcitabine, faces challenges due to the development of chemoresistance, especially influenced by nicotine in the tumor microenvironment.
- The study investigates how nicotine contributes to this resistance in pancreatic cancer cells (PANC-1 and MIA PaCa-2) and explores the potential of Embelin, a natural compound, to counteract this resistance by enhancing gemcitabine sensitivity.
- Results showed increased resistance markers in nicotine-treated cells, but Embelin significantly reduced cell viability and caused cell cycle arrests, suggesting its potential role as a chemosensitizer in overcoming nicotine-induced chemoresistance.
A series of new thiophene analogues with acarbonitrile-basedmoiety were designed and synthesized via structural optimization. The conjugates were assessed for their in-vitro cytotoxic activity against a human pancreatic cancer cell line (Mia PaCa-2) and among them compound 5b showed IC value of 13.37 ± 2.
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