Publications by authors named "Pooja Mahendra Varman"
Article Synopsis
- Differential activation kinetics of signaling pathways can lead to different cellular outcomes, such as differentiation vs. proliferation, as seen with nerve growth factor (NGF) and epidermal growth factor (EGF) affecting the Raf/MEK/ERK pathway.
- A novel light-gated protein-protein interaction system was developed to manipulate the activation pattern of this pathway, enabling researchers to study its effects on cell behavior.
- The study found that light-induced activation stimulates neurite outgrowth in cells in the absence of growth factors, demonstrating that optimizing light on/off cycles can enhance this process, providing insights into signal transduction dynamics.
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