Publications by authors named "Pooja Bandawane"
Article Synopsis
- The study investigates how antiviral monoclonal antibodies (mAbs), particularly casirivimab and imdevimab (CAS+IMD), affect immune responses when individuals are vaccinated against SARS-CoV-2 after receiving mAb treatment.
- It was found that the presence of CAS+IMD during vaccination reduced the effectiveness of the vaccine in generating neutralizing antibodies, though other immune responses remained intact.
- This reduction in antibody production is linked to "epitope masking," but can be reversed with booster shots, and influences the immune response differently in those who had not yet begun their natural immunity when treated with mAbs.
Unlabelled: Monoclonal antibodies (mAbs) are an attractive therapeutic platform for the prevention and treatment of influenza virus infection. There are two major glycoproteins on the influenza virion surface: hemagglutinin (HA), which is responsible for viral attachment and entry, and neuraminidase (NA), which mediates viral egress by enzymatically cleaving sialic acid to release budding particles from the host cell surface. Broadly neutralizing antibodies (bNAbs) that target the conserved HA central stalk region, such as CR9114, can inhibit both viral entry and egress.
View Article and Find Full Text PDFHighly pathogenic avian influenza viruses of the H5N1 clade 2.3.4.
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- H9N2 influenza A viruses have become common in poultry in the Middle East and Asia, leading to an increase in human infections.
- A novel strain of H9N2 was found in Egyptian fruit bats, which shares genetic traits with current avian strains, indicating possible recent genetic mixing.
- Research shows that bat H9N2 can replicate and spread in ferrets, infect human lung tissue, and evade certain antiviral defenses, highlighting its potential risk as a pre-pandemic virus.
Highly pathogenic avian influenza viruses of the H5N1 clade 2.3.4.
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