Design of novel pyrimidine based remdesivir analogues with dual target specificity for SARS CoV-2: A computational approach.

As the world undergone unpreceded time of tragedy with the corona virus, many researchers have raised to showcase their scientific contributions in terms of novel configured anti-viral drugs until now. Herein, we designed pyrimidine based nucleotides and assessed for the binding capability with SARS-CoV-2 viral replication targets of nsp12 RNA-dependent RNA polymerase and M main protease. Molecular docking studies showed all the designed compounds to possess good binding affinity, with a few compounds which outperforms the control drug remdesivir GS-5743 and its active form GS-441524.

Purification of PaTx-II from the Venom of the Australian King Brown Snake and Characterization of Its Antimicrobial and Wound Healing Activities.

Infections caused by multi-drug-resistant (MDR) bacteria are a global threat to human health. As venoms are the source of biochemically diverse bioactive proteins and peptides, we investigated the antimicrobial activity and murine skin infection model-based wound healing efficacy of a 13 kDa protein. The active component PaTx-II was isolated from the venom of (Australian King Brown or Mulga Snake).

A critical review of advanced nanotechnology and hybrid membrane based water recycling, reuse, and wastewater treatment processes.

One of the modern challenges is to provide clean and affordable drinking water. Water scarcity is caused by the growing population in the world and pollutants contaminate all remaining water sources. Innovative water treatment solutions have been provided by nanotechnology.

Detoxification of coir pith through refined vermicomposting engaging Eudrilus eugeniae.

Hazardous coir industrial waste, coir pith has been subjected to 50 days vermicomposting with Eudrilus eugeniae by amending nitrogenous legume plant, Gliricidia sepium together with cattle dung in different combinations, after 21 days precomposting using Pleurotus sajor-caju spawn. An increase in electrical conductivity, total NPK and calcium, and a decrease in organic matter, total organic carbon, C/N ratio, C/P ratio and total phenolic content in the final vermicompost were observed. Dehydrogenase, urease and cellulase activity peaked up to 30 days of vermicomposting and then declined.

Mapping the Impact of Non-Tectonic Forcing mechanisms on GNSS measured Coseismic Ionospheric Perturbations.

Global Navigation Satellite System (GNSS) measured Total Electron Content (TEC) is now widely used to study the near and far-field coseismic ionospheric perturbations (CIP). The generation of near field (~500-600 km surrounding an epicenter) CIP is mainly attributed to the coseismic crustal deformation. The azimuthal distribution of near field CIP may contain information on the seismic/tectonic source characteristics of rupture propagation direction and thrust orientations.

Cefepime vs. cefoperazone/sulbactam in combination with amikacin as empirical antibiotic therapy in febrile neutropenia.

Purpose: Beta lactams are standard empirical therapy for febrile neutropenia (FN). The aim of this study was to evaluate the efficacy and safety of cefepime monotherapy compared with cefoperazone/sulbactam plus amikacin (CS + A) for empirical treatment of high risk FN.

Methods: One hundred seventy-five patients with 336 FN episodes were randomized to receive either cefepime (2 g q8h for adults and 50 mg/kg q8h for children) or CS (2 g q8h for adults and 50 mg/kg q8h for children) plus amikacin (15 mg/kg once a day).

Karyomegalic interstitial nephropathy following ifosfamide therapy.

Ifosfamide (IFO), an alkylating agent used for the management of solid organ tumors, can cause reversible Fanconi's syndrome and acute kidney injury. Karyomegalic interstitial nephropathy (KIN) is a rare form of chronic tubulointerstitial nephritis, initially described as a familial nephropathy in adults. So far, four cases of KIN have been reported in pediatric and adolescent population following treatment with IFO.

Removal Rate of Organic Matter Using Natural Cellulose via Adsorption Isotherm and Kinetic Studies.

In this study, the removal of natural organic matter (NOM) using coconut fiber (CF) and palm oil fiber (POF) was investigated. Preliminary analysis was performed using a jar test for the selection of optimal medium before the fabricated column model experiment. The equilibrium studies on isotherms and kinetic models for NOM adsorption were analyzed using linearized correlation coefficient.

Perspectives of phytoremediation using water hyacinth for removal of heavy metals, organic and inorganic pollutants in wastewater.

The development of eco-friendly and efficient technologies for treating wastewater is one of the attractive research area. Phytoremediation is considered to be a possible method for the removal of pollutants present in wastewater and recognized as a better green remediation technology. Nowadays the focus is to look for a sustainable approach in developing wastewater treatment capability.

Efficiency of barium removal from radioactive waste water using the combination of maghemite and titania nanoparticles in PVA and alginate beads.

In this paper, both maghemite (γ-Fe2O3) and titanium oxide (TiO2) nanoparticles were synthesized and mixed in various ratios and embedded in PVA and alginate beads. Batch sorption experiments were applied for removal of barium ions from aqueous solution under sunlight using the beads. The process has been investigated as a function of pH, contact time, temperature, initial barium ion concentration and TiO2:γ-Fe2O3 ratios (1:10, 1:60 and 1).

A study on large scale cultivation of Microcystis aeruginosa under open raceway pond at semi-continuous mode for biodiesel production.

The study explores on upstream and downstream process in Microcystis aeruginosa for biodiesel production. The alga was isolated from temple tank, acclimatized and successfully mass cultivated in open raceway pond at semi-continuous mode. A two step combined process was designed and harvested 99.

Thermal comfort of various building layouts with a proposed discomfort index range for tropical climate.

Recent years have seen issues related to thermal comfort gaining more momentum in tropical countries. The thermal adaptation and thermal comfort index play a significant role in evaluating the outdoor thermal comfort. In this study, the aim is to capture the thermal sensation of respondents at outdoor environment through questionnaire survey and to determine the discomfort index (DI) to measure the thermal discomfort level.