Iron Status in Newly Diagnosed -Thalassemia Major: High Rate of Iron Status due to Erythropoiesis Drive.

Background: Iron overload in severe -thalassemia is a serious complication that occurs during the course of the disease. Information about the iron status during initial illness with -thalassemia major seemed to be limited. This study is aimed at analyzing iron status, serum hepcidin, and growth differentiation factor 15 (GDF15) levels in newly diagnosed -thalassemia major.

Time to Start Delivering Iron Chelation Therapy in Newly Diagnosed Severe -Thalassemia.

Background: Iron overload is still a major complication of severe -thalassemia. Indication to start iron chelation therapy is based on serum ferritin (SF) or transferrin saturation (TS) level or the amount of transfusion. The goal of this study is to analyse the pattern of iron status, the amount of transfusion regarding the time to start iron chelator, and serum hepcidin levels in newly diagnosed severe -thalassemia.

Immune response of thalassemia major patients in Indonesia with and without splenectomy.

Aim: to describe non-spesific and specific immune response profile in Indonesian thalassemia major with and without splenectomy.

Methods: this study was held at Thalassaemia Centre, Cipto Mangunkusumo Hospital Jakarta on September 2013-February 2014. A comparative cross sectional study was conducted in healthy, thalassemia major aged more than 12 year and seronegative HIV.

Early resuscitation of dengue shock syndrome in children with hyperosmolar sodium-lactate: a randomized single-blind clinical trial of efficacy and safety.

Introduction: Dengue shock syndrome (DSS) fluid resuscitation by following the World Health Organization (WHO) guideline usually required large volumes of Ringer lactate (RL) that might induce secondary fluid overload. Our objective was to compare the effectiveness of the recommended volume of RL versus a smaller volume of a hypertonic sodium lactate solution (HSL) in children with DSS. The primary end point was to evaluate the effect of HSL on endothelial cell inflammation, assessed by soluble vascular cell adhesion molecule-1 (sVCAM-1) measurements.