A 4-week, double-blind comparison of olanzapine with haloperidol in the treatment of amphetamine psychosis.

Objective: To compare the efficacy and tolerability of olanzapines and haloperidol in treating patients with amphetamine psychosis.

Material And Method: Fifty-eight patients experiencing episode of amphetamine psychosis were randomly assigned to olanzapine (N=29) or haloperidol (N=29) in 1:1 (olanzapine: haloperidol) ratio. All patients started with 5-10 mg/day of the study drug; after each 7-day period, the study drug could be adjusted in 5-mg increments or decrements within the allowed dose range of 5-20 mg/day during the 4-week double-blind period.