Grating Structures for Silver-Based Surface Plasmon Resonance Sensors with Adjustable Excitation Angle.

Silver-based grating structures offer means for implementing low-cost, efficient grating couplers for use in surface plasmon resonance (SPR) sensors. One-dimensional grating structures with a fixed periodicity are confined to operate effectively within a single planar orientation. However, two-dimensional grating structures as well as grating structures with variable periodicity allow for the plasmon excitation angle to be seamlessly adjusted.

Optimizing Stability and Performance of Silver-Based Grating Structures for Surface Plasmon Resonance Sensors.

The use of surface plasmon resonance sensors allows for the fabrication of highly sensitive, label-free analytical devices. This contribution reports on a grating coupler to enable surface plasmon resonance studies using silver on silicon oxide technology to build long-term stable plasmonic structures for biological molecule sensing. The structural parameters were simulated and the corresponding simulation model was optimized based on the experimental results to improve its reliability.

Novel p16 binding peptide development for p16-overexpressing cancer cell detection using phage display.

Protein p(16INK4a) (p16) is a well-known biomarker for diagnosis of human papillomavirus (HPV) related cancers. In this work, we identify novel p16 binding peptides by using phage display selection method. A random heptamer phage display library was screened on purified recombinant p16 protein-coated plates to elute only the bound phages from p16 surfaces.