Treatment of Acne With a 1726 nm Laser, Air Cooling, and Real-Time Temperature Monitoring, Software-Assisted Power Adjustment to Achieve a Temperature Endpoint With Selective Sebaceous Gland Photothermolysis.

Objectives: This work highlights the methods used to develop a multi-pulse 1726 nm laser system combined with bulk air-cooling for selective sebaceous gland (SG) photothermolysis using thermal imaging and software algorithms. This approach enables treating to a desired tissue temperature and depth to provide a safe, effective, reproducible, and durable treatment of acne.

Methods: We designed and built a 1726 nm laser system with a 40 W maximum power output, a highly controlled air-cooling device, and a thermal camera in the handpiece, which permits real-time temperature monitoring of the epidermis.

Focal point technology: Controlling treatment depth and pattern of skin injury by a novel highly focused laser.

Background: Selective photothermolysis has limitations in efficacy and safety for dermal targets. We describe a novel concept using scanned focused laser microbeams for precise control of dermal depth and pattern of injury, using a 1550 nm laser that generates an array of conical thermal zones while minimizing injury to the epidermis.

Objective: To characterize the conical thermal zones in vivo and determine safe starting parameters to transition to a second phase to explore potential clinical indications.

Treating pediatric port-wine stains in aesthetics.

A port-wine stain (PWS) is a vascular birthmark present in 0.3% to 0.5% of newborns.

Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping.

Introduction: Port-wine birthmarks (PWBs) are congenital capillary malformations that can be located on any area of the body. Vascular features include vessel size, depth, and density, which can greatly differ between patients, individual lesions, and even sites within the same lesion. Previous studies have determined that the location of PWB lesions has impacted their clinical response to laser treatment.

Paired facial treatment with 755nm picosecond laser with diffractive lens array and 1060nm laser lipolysis of the submentum: An open-label prospective trial.

Background: Performing multiple cosmetic treatments in a single session to target different aspects of facial rejuvenation is an effective regimen. Picosecond lasers with a fractionated handpiece can target fine lines, which can supplement submental fat reduction procedures. However, limited data exist on the safety and efficacy of single-session treatment strategies.

Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography.

Background: Port wine birthmarks (PWBs) are congenital capillary malformations. Vessel characteristics, such as diameter and depth, may impact presentation and outcomes. They can be imaged using dynamic optical coherence tomography, a high-resolution, noninvasive imaging method.

Safety Profile of Combined Same-Day Treatment for Botulinum Toxin With Full Face Nonablative Fractionated Laser Resurfacing.

Background: Spread of botulinum toxin outside the treated muscle is a concern, when energy-based device treatment is performed on the same day as toxin injection.

Objective: We assessed the frequency of eyelid ptosis after the glabella/periorbital botulinum toxin injection and nonablative fractionated laser performed at the same session.

Methods And Materials: This single-center, retrospective study identified treatments consisting of glabella and/or periorbital botulinum toxin injection and nonablative fractionated laser treatment to full face from 2017 to 2019 and eyelid ptosis determined by documentation of the complication at a follow-up encounter, or prescription of apraclonidine.

Dynamic Optical Coherence Tomography of Cutaneous Blood Vessels in Melasma and Vessel Response to Oral Tranexamic Acid.

Background And Objectives: Melasma may be related to aberrant blood vessels, but there has been no report on the utility of dynamic optical coherence tomography (D-OCT) in studying vessel characteristics in melasma. We studied the characteristics of cutaneous blood vessels in melasma and the effects of oral tranexamic acid (TXA) with D-OCT.

Study Design/materials And Methods: Six patients with moderate to severe melasma had a D-OCT scanning of the areas on the face affected by melasma and not affected by it.

Case Series of Fractional Ablative Laser Resurfacing of Pediatric Facial Traumatic and Surgical Scars.

Background And Objectives: Fractional ablative 10,600-nm carbon dioxide (CO ) laser has well-demonstrated safety and efficacy in resurfacing treatment of scars in the adult population and in the treatment of pediatric burn scars. However, there is a paucity of literature regarding laser resurfacing of traumatic and surgical scars for cosmetic benefit in the pediatric population, and in majority of cases previously reported, this was done under general anesthesia.

Study Design/materials And Methods: This was a retrospective chart review of pediatric patients under the age of 18 who underwent fractional ablative CO laser resurfacing (FALR) of traumatic or surgical scars at a single center between 2018 and 2019, inclusive.

Flagellate Dermatitis After Ingestion of Shiitake Mushrooms in a Healthy Female Living in the Southeastern United States.

Background: Shiitake flagellate dermatitis is a shiitake mushroom (SM)-induced toxic dermatosis that is a widely recognized clinical phenomenon in Japan, China, and Korea but is rarely reported outside of Asia. Typically, 24-48 hours after consumption of SM, patients develop severely pruritic, linear, often parallel, infiltrated erythematous lesions, commonly described as being in a "whip-like" pattern. The dermatosis is noted preferentially on the trunk, extremities, and neck.

Peculiar vegetative tumor-like genital herpes simplex nodules with brisk tissue eosinophilia in patients with human immunodeficiency virus infection.

Genital herpes simplex virus (HSV) infection in a human immunodeficiency virus (HIV) patient can present as a vegetative nodule. Clinical differential diagnoses of the nodule include condyloma latum, condyloma acuminatum, viral or fungal infection, and cutaneous neoplasms. Histological examination of herpetic nodules has been reported to show thick pseudoepitheliomatous hyperplasia with dense dermal lymphoplasmacytic infiltrate and multifocal multinucleated cells with herpetic viral cytopathic changes.

Association between quantitative varicella-zoster virus antibody levels and zoster reactivation in HIV-infected persons.

Background: Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons.

Objective: Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster.

Study Design: US Military HIV Natural History (NHS) participants with a zoster diagnosis at least 5 years after HIV diagnosis (n = 100) were included.

Prevalence of hidradenitis suppurativa among patients with Down syndrome: a population-based cross-sectional analysis.

Background: Hidradenitis suppurativa (HS) has been linked to Down syndrome (DS).

Objectives: To determine whether patients with DS have a higher prevalence of HS, and whether the diagnosis of HS occurs at an earlier age for these patients.

Methods: A cross-sectional analysis was performed for a population sample of 11 936 patients with DS and 16 813 290 patients without DS.

Validation and comparison of quality-of-life measures for topical 5-fluorouracil treatment: results from a randomized controlled trial.

Background: Topical 5-fluorouracil (5-FU) is commonly used for high-risk patients with keratinocyte carcinoma (KC). Skindex and Skin Cancer Index (SCI) are validated instruments to measure quality of life (QoL) of patients with KC and those who have had surgical treatment of KCs.

Aim: To validate Skindex and SCI for topical 5-fluorouracil (5-FU) application and to compare the two QoL instruments.

Pubertal Timing and Youth Internalizing Psychopathology: The Role of Relational Aggression.

The current study examined relational aggression as a potential mechanism that explains the association between off-time pubertal development and internalizing problems in youth. Youth gender was also examined as a moderator for the association between these variables. It was hypothesized that early pubertal maturation would be associated with higher levels of relationally aggressive behavior which, in turn, would be associated with elevated levels of internalizing problems.

Father Participation in Child Psychopathology Research.

The purpose of the current study was two-fold: (1) To examine time trends of the inclusion of fathers in child psychopathology research from 2005 to 2015; and (2) to examine online crowdsourcing as a method to recruit and study fathers. In study 1, findings indicated that, relative to two earlier reviews of father participation from 1984 to 1991 and 1992-2004, there has been limited progress in the inclusion of fathers in child psychopathology research over the last decade. In study 2, without explicit efforts to recruit fathers, almost 40% of a sample of 564 parents recruited from online crowdsourcing (Amazon's Mechanical Turk) were fathers.

Costs of Keratinocyte Carcinoma (Nonmelanoma Skin Cancer) and Actinic Keratosis Treatment in the Veterans Health Administration.

Background: The Veterans Health Administration (VHA) provides health care to large numbers of veterans afflicted with keratinocyte carcinoma (KC).

Objective: To estimate the number of veterans treated for KCs and the related diagnosis, actinic keratosis (AK) and the costs of treating these conditions over a 1-year period.

Materials And Methods: The authors conducted a cross-sectional analysis of veterans diagnosed with KC or AK during fiscal year 2012 using administrative data on outpatient encounters and prescription drugs provided or paid by VHA.

Validation of Photograph-Based Toxicity Score for Topical 5-Fluorouracil Cream Application.

Background: An objective tool quantifying the toxicity of 5-fluorouracil (5-FU) from photographs was recently reported, and its reliability was confirmed.

Objective: The aim of this study was to validate the photograph-based toxicity score.

Methods: Photograph-based toxicity scores of participants assigned to the 5-FU arm of a randomized placebo-controlled trial were tested for correlations with their patient-reported symptom scores and baseline characteristics.