Publications by authors named "Polyn Luz S Pine"
Glucagon-like peptide 1 receptor agonists modestly reduced low-density lipoprotein cholesterol and total cholesterol levels independent of weight reduction: a meta-analysis and meta-regression of placebo controlled randomized controlled trials.
Curr Med Res Opin
December 2024
Article Synopsis
- GLP-1 receptor agonists (GLP-1RAs) show a modest decrease in low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) based on a review of clinical trials.
- The analysis found no significant impact on triglycerides, very low-density lipoprotein cholesterol (VLDL-C), or high-density lipoprotein cholesterol (HDL-C).
- Weight changes did not have a notable effect on LDL-C or TC levels among study participants.
Background: Randomized controlled trials (RCTs) of glucagon-like peptide 1 receptor agonists (GLP-1RAs) form the basis for therapeutic recommendations for both males and females. Historically, females have been significantly underrepresented in RCTs.
Objectives: The authors sought to determine the trends of representation of females in GLP-1RA RCTs from 2007 to 2024.
Sex Disparity in the In-Hospital Outcomes of Patients with Kidney Disease Admitted for Myocardial Infarction: Insights from a Large National Database.
Cardiorenal Med
September 2024
Introduction: There is limited evidence as to the effect of sex on the outcomes of patients admitted for ST-elevation myocardial infarction (STEMI) who have a concomitant diagnosis of chronic kidney disease (CKD) and end-stage renal disease (ESRD). We aimed to determine if there are differences in the outcomes between males and females in these patient populations.
Methods: Data were obtained from the National Inpatient Sample database and patients were selected using the International Classification of Diseases, Ninth and Tenth Revision (ICD-9 and -10) codes.
Introduction: Studies exploring the effectiveness and safety of left atrial appendage occlusion (LAAO) in patients with chronic kidney disease (CKD) are limited.
Methods: We utilized the National Inpatient Sample (NIS) to identify hospitalizations for LAAO from 2016 to 2020 and further identified cases with concomitant CKD. The primary outcome was mortality, and secondary outcomes were cerebrovascular accidents, major bleeding, vasopressor requirements, percutaneous coronary intervention, cardiac arrest, acute respiratory failure, transfusion, length of stay (LOS), and total hospital charges.