[Informativeness estimation for the main clinical and laboratory parameters in patients with severe COVID-19].

Aim: To conduct a retrospective assessment of the clinical and laboratory data of patients with severe forms of COVID-19 hospitalized in the intensive care and intensive care unit, in order to assess the contribution of various indicators to the likelihood of death.

Materials And Methods: A retrospective assessment of data on 224 patients with severe COVID-19 admitted to the intensive care unit was carried out. The analysis included the data of biochemical, clinical blood tests, coagulograms, indicators of the inflammatory response.

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery.

Objective: To evaluate the use of terlipressin for intraoperative bleeding reduction in functional endoscopic sinus surgery (FESS).

Methods: This prospective, randomized, single-center, single-blinded cohort study included 74 cases of FESS performed under general anesthesia (GA). The patients were randomized into two groups: WT (without terlipressin, n = 39) and T (with 200 μg terlipressin, n = 35).

Fraction of plasma exomeres and low-density lipoprotein cholesterol as a predictor of fatal outcome of COVID-19.

Transcriptomic analysis conducted by us previously revealed upregulation of genes involved in low-density lipoprotein particle receptor (LDLR) activity pathway in lethal COVID-19 caused by SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2). Last data suggested the possible role of extracellular vesicles in COVID-19 pathogenesis. The aim of the present study was to retrospectively evaluate parameters of cholesterol metabolism and newly identified EVs, exomeres, as possible predictors of fatal outcome of COVID-19 patients infected by the Alpha and the Delta variants of SARS-CoV-2 virus.

[Beta-blockers for reducing intraoperative bleeding during rhinosinusosurgical operations in elderly and senile patients.].

With the ineffectiveness of conservative therapy of chronic rhinosinusitis in all age groups of patients, functional rhinosinusosurgical endoscopic interventions are now often used to do. The minimal bleeding is a necessary condition for their realization. There are reports of the use of beta-blockers for reducing surgical bleeding, but the possibility of their intravenous use in older patients has not been sufficiently studied.

A Novel Approach for COVID-19 Patient Condition Tracking: From Instant Prediction to Regular Monitoring.

The aim of this research is to develop an accurate and interpretable aggregated score not only for hospitalization outcome prediction (death/discharge) but also for the daily assessment of the COVID-19 patient's condition. In this single-center cohort study, real-world data collected within the first two waves of the COVID-19 pandemic was used (27.04.

Transcriptomic Profiles Reveal Downregulation of Low-Density Lipoprotein Particle Receptor Pathway Activity in Patients Surviving Severe COVID-19.

To assess the biology of the lethal endpoint in patients with SARS-CoV-2 infection, we compared the transcriptional response to the virus in patients who survived or died during severe COVID-19. We applied gene expression profiling to generate transcriptional signatures for peripheral blood mononuclear cells (PBMCs) from patients with SARS-CoV-2 infection at the time when they were placed in the Intensive Care Unit of the Pavlov First State Medical University of St. Petersburg (Russia).

Ruxolitinib versus dexamethasone in hospitalized adults with COVID-19: multicenter matched cohort study.

Background: Several anti-cytokine therapies were tested in the randomized trials in hospitalized patients with severe acute respiratory syndrome coronavirus 2 infection (COVID-19). Previously, dexamethasone demonstrated a reduction of case-fatality rate in hospitalized patients with respiratory failure. In this matched control study we compared dexamethasone to a Janus kinase inhibitor, ruxolitinib.

[Homoarginine level and methionine-homocysteine balance in patients with ischemic heart disease.].

The level of homoarginine (hArg) in terms of prognostic significance may exceed the natriuretic peptides and other well-known markers according to the latest data about the progression of cardiovascular diseases. The lack of data on the association of hArg levels with levels of other metabolites makes it difficult to understand its role in the pathogenesis of cardiovascular diseases. Relationships of hArg and other amino acids, including methionine (Met) and total homocysteine (tHcy), and their ratio in patients with ischemic heart disease were evaluated.

[The level of circulating humanin in patients with ischemic heart disease.].

At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to the presence of secondary mitochondrial dysfunction in patients with coronary heart disease. Сoronary heart disease is generally accompanied with a decline in mitochondrial respiration and represents the root cause of metabolic abnormalities in tissues. To gain insight into rate of decline of mitochondrial oxidative metabolism in tissues there were proposed humanin as a new marker.

[OLD AND NEW PROBLEMS IN THE TRAINING OF ANAESTHESIOLOGISTS].

In connection with the upcoming changes in the professional education in Russia, there is a need to adapt the existing system of training of anesthesiologists. We sent questionnaires to 831 anesthesiologists to identify their opinion about the planned transition to continuous medical education. We found that the majority of respondents do not object to the implementation in practice of this system, especially if the educational model will be adapted to the specific requests of practitioners.

[PAIN AFTER CHILDBIRTH AND ITS IMPACT ON QUALITY OF LIFE].

Background: Public attitude towards labor pain and pain relief in labor is not fully formed.

Purpose: To study the frequency of formation of acute and chronic pain during delivery.

Materials And Methods: Retrospectively we surveyed 300 women 18-48 years old, who had childbirth naturally or by caesarean section for 4-6 months before the survey and analyzed the history of their childbirth.