Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis.

Chronic non-healing wounds negatively impact quality of life and are a significant financial drain on health systems. The risk of infection that exacerbates comorbidities in patients necessitates regular application of wound care. Understanding the mechanisms underlying impaired wound healing are therefore a key priority to inform effective new-generation treatments.

Formation of MnO-coated ITO electrodes with high catalytic activity for enzymatic glucose detection.

We present the formation of a cheap and environmentally friendly working electrode material for glucose biosensors with good catalytic properties. The classic electrode in such devices consists of a conductive material modified with the enzyme glucose oxidase. The working principle is the electrochemical detection of hydrogen peroxide as a product of the enzymatic transformation of glucose.

CXCR4-CCR7 Heterodimerization Is a Driver of Breast Cancer Progression.

Metastatic breast cancer has one of the highest mortality rates among women in western society. Chemokine receptors CXCR4 and CCR7 have been shown to be linked to the metastatic spread of breast cancer, however, their precise function and underlying molecular pathways leading to the acquisition of the pro-metastatic properties remain poorly understood. We demonstrate here that the CXCR4 and CCR7 receptor ligands, CXCL12 and CCL19, cooperatively bind and selectively elicit synergistic signalling responses in invasive breast cancer cell lines as well as primary mammary human tumour cells.

Mechanical Signaling in the Mammary Microenvironment: From Homeostasis to Cancer.

It is becoming increasingly appreciated that biophysical influences on tissues are at least as important as biochemical influences in regulating normal development and homeostasis. Furthermore, diseases of aberrant tissue homeostasis such as cancers are driven by the abnormal biophysics of cancerous tissues. The mammary gland, a mechanoresponsive tissue, is exquisitely sensitive to changes in its mechanical microenvironment.

Extrusion of shrimp shell-polylactic acid composites: Dataset for the impact of surfactants on their morphology and thermal properties.

Shrimp shell waste obtained from Louisiana Gulf shrimp (Litopenaeus setiferus) was heat-treated at varying temperatures and ground into a powder by ball-milling. The powder was used with and without surface treatment with maleic anhydride or stearic acid to form shrimp shell - polylactic acid (PLA) composite granules by solution processing and mechanical grinding. These granules were used as feedstock for the extrusion of composite filaments.

Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.

It is well accepted that cancers co-opt the microenvironment for their growth. However, the molecular mechanisms that underlie cancer-microenvironment interactions are still poorly defined. Here, we show that Rho-associated kinase (ROCK) in the mammary tumour epithelium selectively actuates protein-kinase-R-like endoplasmic reticulum kinase (PERK), causing the recruitment and persistent education of tumour-promoting cancer-associated fibroblasts (CAFs), which are part of the cancer microenvironment.

The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity.

The microenvironment encompasses all components of a tumor other than the cancer cells themselves. It is highly heterogenous, comprising a cellular component that includes immune cells, fibroblasts, adipocytes, and endothelial cells, and a non-cellular component, which is a meshwork of polymeric proteins and accessory molecules, termed the extracellular matrix (ECM). The ECM provides both a biochemical and biomechanical context within which cancer cells exist.

The chemokine receptor CCR7 promotes mammary tumorigenesis through amplification of stem-like cells.

The chemokine receptor CCR7 is widely implicated in breast cancer pathobiology. Although recent reports correlated high CCR7 levels with more advanced tumor grade and poor prognosis, limited in vivo data are available regarding its specific function in mammary gland neoplasia and the underlying mechanisms involved. To address these questions we generated a bigenic mouse model of breast cancer combined with CCR7 deletion, which revealed that CCR7 ablation results in a considerable delay in tumor onset as well as significantly reduced tumor burden.

Multistep soft chemistry method for valence reduction in transition metal oxides with triangular (CdI2-type) layers.

Transition metal (M) oxides with MO2 triangular layers demonstrate a variety of physical properties depending on the metal oxidation states. In the known compounds, metal oxidation states are limited to either 3+ or mixed-valent 3+/4+. A multistep soft chemistry synthetic route for novel phases with M(2+/3+)O2 triangular layers is reported.

Low-temperature solvothermal approach to the synthesis of La4Ni3O8 by topotactic oxygen deintercalation.

A chimie douce solvothermal reduction method is proposed for topotactic oxygen deintercalation of complex metal oxides. Four different reduction techniques were employed to qualitatively identify the relative reduction activity of each including reduction with H(2) and NaH, solution-based reduction using metal hydrides at ambient pressure, and reduction under solvothermal conditions. The reduction of the Ruddlesden-Popper nickelate La(4)Ni(3)O(10) was used as a test case to prove the validity of the method.

Bulk magnetic order in a two-dimensional Ni1+/Ni2+ (d9/d8) nickelate, isoelectronic with superconducting cuprates.

The Ni1+/Ni2+ states of nickelates have the identical (3d(9)/3d(8)) electronic configuration as Cu2+/Cu3+ in the high temperature superconducting cuprates, and are expected to show interesting properties. An intriguing question is whether mimicking the electronic and structural features of cuprates would also result in superconductivity in nickelates. Here we report experimental evidence for a bulklike magnetic transition in La4Ni3O8 at 105 K.

Electronic properties, band structure, and fermi surface instabilities of Ni1+/Ni2+ nickelate La3Ni2O6, isoelectronic with superconducting cuprates.

Electronic structure calculations were performed for the mixed-valent Ni(1+)/Ni(2+) nickelate La3Ni2O6, which exhibits electronic instabilities of the Fermi surface similar to that of the isostructural superconducting La2CaCu2O6 cuprate. La3Ni2O6 shows activated hopping, which fits to Mott's variable-range-hopping model with localized states near the Fermi level. However, a simple local spin density approximation calculation leads to a metallic ground state.

Crystal structures of Ln4Ni3O8 (Ln = La, Nd) triple layer T'-type nickelates.

Single-phase Ln4Ni3O8 (Ln = La, Nd) nickelates were synthesized and their crystal structures were determined by Rietveld refinement of powder neutron diffraction data. The crystal structures of these mixed-valent Ni1+/Ni2+ phases belong to the T'-type and are built by intergrowth of LnO2 fluorite layers with triple NiO2 infinite-layer structural blocks. The major driving force of transformation of the LnO rock-salt block of the parent Ln4Ni3O10-delta Ruddlesden-Popper phases to the fluorite arrangement in the reduced Ln4Ni3O8 phases is attributed to internal structural stress.

La3Ni2O6: a new double T'-type nickelate with infinite Ni1+/2+O2 layers.

New mixed-valent, Ni1+/Ni2+, metastable nickelate, La3Ni2O6, was synthesized by low-temperature reduction of La3Ni2O7 with CaH2. The crystal structure of La3Ni2O6 (space group: I4/mmm, a = 3.9686(1) A and c = 19.

[The prognosis for the development of gestoses taking into account the psychophysiological individuality of pregnant women].

Psychophysiological predictors of gestosis have been determined in pregnant women followed up at an antenatal clinic. They typically exhibited anxiety states with increased neuroticism, an introverted personality, impairment of brainstem-subcortical relations due to dysfunctions of nonspecific units of the visceral brain and their activating effects on the normal cortex, exaggerated cutaneous galvanic reflexes. A clinical follow-up of women at an increased risk showed the onset of edematous nephrotic gestosis in 62.

[Characteristics of the autonomic nervous system tests during group psychotherapy of patients with opioid dependence at the stage of induction of remission].

The time-course of changes in vegetative tests was studied in 47 men suffering from stage II opium dependence. The patients' age ranged from 18 to 28 years, with the dependence standing amounting to 1-10 years. Use was made of cardiointervalography to define the vegetative tone, as well as of the vagal and adrenaline tests to explore vegetative responsiveness.

[Role of ethanol tolerance in determining a hereditary disposition to alcoholism].

Genetic-correlative analysis of the tolerance level, amount of alcohol consumed (ml/kg for 1 year) as well as predisposition to the development of alcoholism permitted an assumption on existence of two different genetic factors one of which determined the tolerance level and the other one-predisposition to disease.