New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere.

Introduction: Endometrial cancer (EC) is the only gynecologic malignancy showing increasing trends in incidence and mortality. While standard treatment has been effective primarily for early-stage EC, precision medicine with tailored therapy has revolutionized the management of this disease. Genome sequencing analyses have identified four sub-types of EC.

Increased reliability of CT-imaging signs of bleeding into soft tissue in patients with COVID-19 for planning transarterial embolization.

Introduction: Spontaneous bleeding into the soft tissues of the abdominal and thoracic wall is described as complication of anticoagulant therapy. Computed tomography (CT) allows to detect the presence of extravasation of the contrast agent into a hematoma, which is indicated as a sign of ongoing bleeding. Other specific CT signs of such coagulopathic bleeding have been described earlier.

Gonadotropin-releasing hormone-like receptor 2 inversely regulates somatic proteostasis and reproduction in .

The quality control machinery regulates the cellular proteome to ensure proper protein homeostasis (proteostasis). In , quality control networks are downregulated cell-nonautonomously by the gonadal longevity pathway or metabolic signaling at the onset of reproduction. However, how signals are mediated between the gonad and the somatic tissues is not known.

Multi-modal Dataset of a Polycrystalline Metallic Material: 3D Microstructure and Deformation Fields.

The development of high-fidelity mechanical property prediction models for the design of polycrystalline materials relies on large volumes of microstructural feature data. Concurrently, at these same scales, the deformation fields that develop during mechanical loading can be highly heterogeneous. Spatially correlated measurements of 3D microstructure and the ensuing deformation fields at the micro-scale would provide highly valuable insight into the relationship between microstructure and macroscopic mechanical response.

Ectopic pregnancy of the fundal myometrium in a patient with tuberous sclerosis.

A myometrial ectopic pregnancy is a rare and potentially fatal diagnosis. This diagnosis should be considered when presented with large increases in serum beta-hCG with no evidence of an intrauterine pregnancy, particularly with altered myometrium.

Postmenopausal endometriosis presenting as a pelvic mass invading the colon.

An invading mass in a postmenopausal female is usually suspicious of being cancerous. Even though, endometriosis should always be included in the differential since its surgical management involves significant morbidity and even mortality.

A defect-resistant Co-Ni superalloy for 3D printing.

Additive manufacturing promises a major transformation of the production of high economic value metallic materials, enabling innovative, geometrically complex designs with minimal material waste. The overarching challenge is to design alloys that are compatible with the unique additive processing conditions while maintaining material properties sufficient for the challenging environments encountered in energy, space, and nuclear applications. Here we describe a class of high strength, defect-resistant 3D printable superalloys containing approximately equal parts of Co and Ni along with Al, Cr, Ta and W that possess strengths in excess of 1.

Viable triplet pregnancy coexisting with a complete molar pregnancy.

This case is extraordinary because it was never before described in English literature. The case describes a long-standing debate about the safety of carrying this pregnancy to term. Some authors are for and some are against.

Persistence of hypercalciuria after successful surgical treatment for primary hyperparathyroidism.

Unlabelled: Primary hyperparathyroidism (PHPT) causes hypercalciuria and stone disease in a subset of patients. Hypercalciuria typically normalizes after surgery, although the risk of stone formation may persist up to 10 years. There are few reports in the literature that show persistent hypercalciuria despite normalization of serum calcium after parathyroid surgery.

[Primary hyperparathyroidism: postoperative long-term evolution].

The long-term postoperative outcome of 87 patients with primary hyperparathyrodism is here presented. Of the total 78 were females and 9 males, ratio: 8.7:1.

Long-term treatment of renal lithiasis with potassium citrate.

Objective: To evaluate the urine metabolic changes induced by sustained potassium citrate (KCit) treatment in patients with either hypocitraturia (HCit) or "unduly acidic urine pH" (UAUpH), and to determine the remission rate in those patients treated for more than 24 months.

Methods: We retrospectively reviewed the charts of 215 adult patients with recurrent renal stones whose only urinary metabolic risk factors were either HCit (n = 95) or UAUpH (n = 120) and had been treated with KCit for more than 3 months.

Results: In patients with Hcit (55 men and 40 women, mean age was 43 ± 14 years), Kcit therapy (average dose 48 ± 14.

Familial hemolytic uremic syndrome associated with complement factor H deficiency.

Atypical hemolytic uremic syndrome (HUS) associated with factor H deficiency (FHD) carries a poor prognosis. A 3-year-old girl with FHD-HUS reached end-stage renal disease at age 6 months after experiencing numerous relapses; she underwent a cadaveric renal transplant at age 46 months. One month after transplantation, she experienced an extensive non-hemorrhagic cerebral infarction.

Neuronal activity in human primary visual cortex correlates with perception during binocular rivalry.

During binocular rivalry, two incompatible monocular images compete for perceptual dominance, with one pattern temporarily suppressed from conscious awareness. We measured fMRI signals in early visual cortex while subjects viewed rival dichoptic images of two different contrasts; the contrast difference served as a 'tag' for the neuronal representations of the two monocular images. Activity in primary visual cortex (V1) increased when subjects perceived the higher contrast pattern and decreased when subjects perceived the lower contrast pattern.

Contaminant assimilation within the water column of two newly created prairie wetlands.

This research examined the influence of abiotic factors on contaminant assimilation within the water column of two wetlands (RMA3 and RMA4) located on Rocky Mountain Arsenal National Wildlife Area, north of Denver, Colorado, USA. We define contaminant assimilation as the ability of a wetland system to reduce negative impacts of contaminants on aquatic organisms. To examine the influence of abiotic factors (i.