Effects of intra-arterial octreotide on pancreatic texture: a randomized controlled trial.

Background And Aims: Octreotide is suggested to harden the pancreas, thus facilitating the construction of a pancreatic anastomosis and lowering the risk of postoperative fistula. We tested the hypothesis that intra-arterial application of octreotide in the gastroduodenal artery during pancreatectomy may increase pancreatic hardness.

Material And Methods: A single-center, prospective, double-blinded, randomized controlled trial with parallel assignment was conducted.