Aim: To study activity of transcription factor (TF)--the nuclear factor kappa B (NF-kB)--and its role in formation of endothelial dysfunction (ED) in patients with essential hypertension (EH).
Material And Methods: The examination covered 74 patients with EH stage I-II with the first-third degree of arterial hypertension (AH) by WHO/IHS classification (48 males, 36 females, mean age 46.39 +/- 3.
Geometrical features of contraction of the left ventricle of the heart (LVH) in 41 patients with chronic obstructive bronchitis marked by moderate and severe respiratory disorders without clinical signs of heart insufficiency with the help of a morphobiomechanical have been examined. The patients were selected in subgroups with different ejection fraction of LVH. The patients with diminished ejection fraction were found to have signs which respond to left ventricle dysfunctions of the heart.
View Article and Find Full Text PDFThe study was undertaken to examine a role of pulse blood pressure (PBP) as a diagnostic marker of remodeling of large elastic arteries in patients with hypertensive disease (HD). A hundred and sixty-eight patients with HD and 38 apparently healthy individuals (a control group) were examined. In all the examinees, PBP was measured and central PBP (PBPc) was calculated.
View Article and Find Full Text PDFThe study was undertaken to define a role of connective tissue metabolism (CTM) in the structural and functional changes of arterial vessels in patients with hypertensive disease (HD). Eighty-nine patients with HD and 33 apparently healthy individuals were examined. The morphometrical parameters of the aorta were studied by magnetic resonance imaging (MRI), external and internal diameters (ED and ID, respectively) and the thickness of the wall (Hao) at the level of the ascending aorta and its mass (Mao) were determined.
View Article and Find Full Text PDFThe investigation performed in 117 patients with chronic obstructive bronchitis (COB) revealed a significant decline in quality of life (QL) with progressive disease. Decrement of QL level in patients with stage I and II COB has been found to be primarily associated with activation of the sympathetic nervous system and progressing of metabolic myocardial dystrophy. With stage III COB decline in QL is also caused by reduction of volume of the functional pulmonary parenchyma.
View Article and Find Full Text PDFThe aim of the work is to study the influence of a long-term ipratropium bromide on the character of the functional heart indices changes in patients with chronic obstructive bronchitis. Positive effects on the myocardial reserve are reported under a 2-week atrovent monotherapy. Atrovent favoured a positive trend in clinical symptoms, that determined the myocardial reserve.
View Article and Find Full Text PDFThe condition of the kinin system was studied in 89 patients with inflammatory and functional diseases of the colon. The relatedness has been revealed of the intestine microflora changes and of the blood kinin system activity to morphological changes in the colon mucosa.
View Article and Find Full Text PDFEffects were studied of nebivolol, metoprolol and enalapril maleat on the state of endothelium-dependent vasodilatation of arterioles in patients with essential arterial hypertension. Nebivolol has been shown to effectively decrease blood pressure and restore endothelium-dependent vasodilatation to a grater degree, than enalapril or metoprolol.
View Article and Find Full Text PDFIn the article data of endotheliumprotective effect of enalapril in hypertensive patients with varying degree of systemic hypertension are presented. The above effect was assessed by changes in activity of the von Willebrand factor and degree of arterial vessels dilatation in response to infusion of acetylcholinum.
View Article and Find Full Text PDFA total of 25 patients with duodenal ulcer were examined. Central bloodflow, that of the abdominal cavity, and characteristics of the vegetative tone were studied by the variation pulsometry method. Disturbances were revealed in the hemodynamics, manifested by a drop in cardiac output (CO) and increase in the blood volume which were particularly pronounced in unfavourable course of the disease.
View Article and Find Full Text PDFIt has been established that the degree of ionization of serum calcium increases with the progression of hypertensive disease (HD) concurrently with the elevation of the level of calcitoninemia. Concentrations of parathyroid hormone remain unchanged at early stages of HD and it is not until hypertrophy of the left ventricle becomes clinically apparent that they begin to increase. The data obtained will, we believe, help in accounting for the features of the clinical course of variant forms of hypertrophy of left ventricle in patients with hypertensive disease.
View Article and Find Full Text PDFWith the view to study state of antioxidant protection and membrane lipid peroxidation (LPO) in hypertonic disease (HD) 200 patients with HD of I and II stage (WHO classification) were examined. Structural and functional state of myocardium was assessed echocardiographically. Enzymatic and non-enzymatic LPO, catalase and superoxide-dismutase activity were analyzed in erythrocytes.
View Article and Find Full Text PDFKardiologiia
February 1992
To study the changes occurred in integral calcium metabolic parameters in evolving "hypertensive" heart, a total of 100 patients with Stage I-II (WHO Classification) were examined. Myocardial structure and function were echocardiographically examined. Plasma concentrations of ionized calcium were measured by direct potentiometry.
View Article and Find Full Text PDFThe time course of structural and functional parameters using echocardiography and the level of atrial natriuretic factor (ANF) employing immunoradiometric assay were examined in 37 patients with essential hypertension taking a 3-week therapy with nifedipine (corinfar) in doses individually chosen. The changes in the structural and functional parameters of the hypertensive heart were found to be associated with its endocrine function. A course therapy of patients with essential hypertension with nifedipine in individually based doses caused a significant rise in plasma ANF levels, a normalization of cardiac compensatory mechanism function.
View Article and Find Full Text PDFA radioimmunoassay was used to study the structural and functional status of the myocardium and blood natriuretic factor levels in 45 patients with hypertensive disease and 17 healthy subjects. Left atrial dysfunction was revealed to affect natriuretic factor levels in the blood of hypertensive patients with moderate left ventricular hypertrophy. As myocardial contractility became lower, natriuretic factor levels were reduced.
View Article and Find Full Text PDFThe analysis of data obtained for 101 bronchial asthma (BA) sufferers with hypertension and 30 normotensive patients demonstrated the dependence of arterial hypertension in BA patients on a significant increase in the systemic peripheral resistance, pulmonary circulation pressure, diastolic dysfunction, reduced cardiac output, pulse brain filling as well as on elevated serotonin level and monoamine oxidase hyperactivity. The findings provided additional information on the causes and triggering mechanisms of arterial hypertension in BA patients, are helpful in design of antihypertensive treatment and the disease prevention.
View Article and Find Full Text PDFChanges in parameters for cardiac filling and pump functions during graded exercise were studied in 29 hypertensive patients with various left ventricular myocardial mass and 30 healthy subjects by unidirectional echocardiography. The volume of early diastolic filling decreased and that of diastasis and atrial systole increased with increasing left ventricular mass. These changes were found during graded exercises rather than at rest.
View Article and Find Full Text PDFSympatho-adrenal activity (SAA) was assessed in 67 male patients with essential hypertension and 20 normal subjects. The patients were divided into 2 groups: those with increased (group 1) and normal (group 2) basal SAA. Hyperreactive and normally reactive patients were identified on the basis of plasma norepinephrine elevation in response to one-hour walking in both groups.
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