Publications by authors named "Polina V Alyabyeva"
Article Synopsis
- iNOS plays a crucial role in producing nitric oxide to protect cells from environmental harm, but excessive expression can lead to low blood pressure and contribute to conditions like arterial hypertension and tension-type headache.
- A study investigated two specific gene variations (SNPs rs2779249 and rs2297518) for their potential link to overlap syndrome (OS) and hypertension in a sample of Caucasian participants from Eastern Siberia, revealing significant associations.
- Findings indicated that certain alleles (A of rs2779249 and A of rs2297518) were linked to increased risks of both OS and AH, suggesting these SNPs could serve as useful genetic markers for these conditions.
Background: Nitric oxide (NO) is an important autocrine and paracrine signaling molecule that plays a crucial role in cardiovascular physiology and pathology regulation. NO is an important molecule involved in regulation of cerebral and extra cerebral cranial blood flow and arterial diameters. Reduced bioavailability of NO in the endothelium is an important precursor for impaired vasodilation and arterial hypertension (AH).
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