Publications by authors named "Polina M Krassovskaia"
Article Synopsis
- Maternal exercise (ME) has been shown to positively impact infant metabolic health, but most understanding comes from animal studies.
- Research on infant mesenchymal stem cells (MSCs) reveals that ME enhances MSC mitochondrial function and insulin signaling, leading to improved energy use.
- Infants of mothers who exercised were found to be leaner at 1 month, and there was an inverse relationship between MSC respiration and infant fat levels at 6 months.
Article Synopsis
- Resveratrol, a natural compound in plants, is being studied for its potential to treat obesity-related issues like insulin resistance.
- A study analyzed how obesity status (lean vs. severely obese) affects responses to resveratrol in skeletal muscle cells, revealing that lean women showed greater improvements in insulin action with resveratrol than severely obese women.
- The findings suggest that while resveratrol enhances insulin-stimulated glucose metabolism in both groups, the mechanisms may differ, with AMPK activation playing a key role in severely obese individuals.
Background And Aim: Elevated fasting plasma lactate concentrations are evident in individuals with metabolic diseases. However, it has yet to be determined if these associations exist in a young, healthy population as a possible early marker for metabolic disease risk. The purpose of this study was to determine if indices of the metabolic syndrome are related to plasma lactate concentrations in this population.
View Article and Find Full Text PDFContext: Maternal exercise positively influences pregnancy outcomes and metabolic health in progeny; however, data regarding the effects of different modes of prenatal exercise on offspring metabolic phenotype is lacking.
Objective: To elucidate the effects of different modes of maternal exercise on offspring umbilical cord derived mesenchymal stem cell (MSC) metabolism.
Design: Randomized controlled trial.
Article Synopsis
- - African Americans (AA) face higher rates of metabolic diseases, potentially linked to differences in mitochondrial bioenergetics compared to Caucasians (C), revealing underlying inefficiencies in energy usage.
- - Despite having more skeletal muscle mass, AA show lower energy expenditure and resting metabolic rates, which may lead to increased overnutrition but do not fully explain the higher insulin resistance (IR) observed in this group.
- - Key features like reduced mitochondrial function and metabolic flexibility are seen in healthy AA, suggesting that these mitochondrial adaptations could contribute to the racial disparities in IR and metabolic diseases, warranting further research on insulin signaling mechanisms.
Context: Recent preclinical data suggest exercise during pregnancy can improve the metabolic phenotype not only of the mother, but of the developing offspring as well. However, investigations in human offspring are lacking.
Objective: To characterize the effect of maternal aerobic exercise on the metabolic phenotype of the offspring's mesenchymal stem cells (MSCs).
Epidemiological studies show that low birth weight is associated with mortality from cardiovascular disease in adulthood, indicating that chronic diseases could be influenced by hormonal or metabolic insults encountered . This concept, now known as the Developmental Origins of Health and Disease hypothesis, postulates that the intrauterine environment may alter the structure and function of the organs of the fetus as well as the expression of genes that impart an increased vulnerability to chronic diseases later in life. Lifestyle interventions initiated during the prenatal period are crucial as there is the potential to attenuate progression towards chronic diseases.
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