Publications by authors named "Polina Kamkina"
Article Synopsis
- Complex traits are influenced by multiple genes and signaling pathways, such as apoptosis and MAPK, but how genetic variation affects these pathways at the translation level is not well understood.
- This study used Caenorhabditis elegans to investigate how natural genetic variation impacts protein levels in key developmental signaling pathways through QTL mapping.
- The findings revealed that about half of the tested genes showed significant changes in protein abundance, highlighting the role of genetic variation in affecting signaling pathways and phenotypic outcomes.
Natural genetic variation is the raw material of evolution and influences disease development and progression. An important question is how this genetic variation translates into variation in protein abundance. To analyze the effects of the genetic background on gene and protein expression in the nematode Caenorhabditis elegans, we quantitatively compared the two genetically highly divergent wild-type strains N2 and CB4856.
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