Application of an in vitro new approach methodology to determine relative cancer potency factors of air pollutants based on whole mixtures.

Air pollution is an example of a complex environmental mixture with different biological activities, making risk assessment challenging. Current cancer risk assessment strategies that focus on individual pollutants may overlook interactions among them, potentially underestimating health risks. Therefore, a shift towards the evaluation of whole mixtures is essential for accurate risk assessment.

Socioeconomic factors increase the adverse effects of air pollution and temperature on mortality.

Objective: To verify the effects of PM2.5 and temperature on mortality due to cardiovascular diseases according to socioeconomic status and traffic proximity.

Method: Time series were used, using the generalized additive models with the Poisson regression option, at 5% significance level.

Risk factors in cardiovascular disease mortality associated with high exposure to vehicular traffic.

Objective: To identify areas and risk factors in cardiovascular disease (CD) mortality associated with air pollution from high exposure to vehicular traffic.

Methods: Cross-sectional study of CD mortality in 2,617 individuals aged 45-85 years living in the urban area of Cuiabá and Várzea Grande, Mato Grosso State, Brazil, between 2009 and 2011. We used the residential proximity of up to 150 meters to a roadway of great vehicle flow as a proxy of high exposure to air pollution from vehicular traffic.

Climatic variability and morbidity and mortality associated with particulate matter.

Objective: The objective of this study has been to analyze whether fine particulate matter (PM2.5), as well as its synergistic effect with maximum temperature, humidity, and seasons, is associated with morbidity and mortality from cardiovascular diseases.

Methods: This is an ecological study of time series.