The Role Ionic Liquid [BMIM][PF] in One-Pot Synthesis of Tetrahydropyran Rings through Tandem Barbier-Prins Reaction.

Tetrahydropyran (THP) rings are common in several natural products, therefore, various strategies are being developed to synthesize these rings. The present work described the study of a one-pot synthesis of 2,4,6-trisubstituted tetrahydropyran compounds promoted by the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF] through a Barbier-Prins reaction between allyl bromide and aldehydes. The use of [BMIM][PF] gave Prins products from several aldehydes in good yields and reaction times.