[The efficacy of tes-therapy for treatment of anxiety-like behavior and motor disorders in rats with an experimental model of parkinsonism].

Aim: To assess the efficacy of transcranial electrostimulation TES for treatmnet of anxiety-like behavior and motor disorders in rats with rotenone-induced parkinsonism.

Material And Methods: The study was performed on 30 mature male-rats. Animals were divided into following groups: control, intact rats (group 1); rats with an experimental model of parkinsonism without treatment (group 2); rats with an experimental model of parkinsonism, which had 7 sessions of TES-therapy (group 3), the number of rats in each group was 10.

Сapsule endoscopy for diagnosis of celiac disease.

In this review we analyzed the guidelines for diagnosis and management of celiac disease, as well as the recent studies published on this issue. Capsule endoscopy could be used in patients unwilling or unable to undergo conventional endoscopy, in patients who have discordant results between serological and histopathological investigation, in patients with nonresponsive or refractory celiac disease.

p-Carborane Conjugation in Radical Anions of Cage-Cage and Cage-Phenyl Compounds.

Optical electron transfer (intervalence) transitions in radical anions of p-carborane oligomers attest to delocalization of electrons between two p-carboranes cages or a p-carborane and a phenyl ring. Oligomers of the 12 vertex p-carborane (CBH) cage, [12], with up to 3 cages were synthesized, as well as p-carboranes with one or two trimethylsilylphenyl groups, [6], attached to the carbon termini. Pulse radiolysis in tetrahydrofuran produced radical anions, determined redox potentials by equilibria and measured their absorption spectra.

[Results of hyperfractionated radiation therapy used in combination with lomustin in malignant gliomas of the brain].

The postoperative use of lomustin, a nitrosourea agent, was investigated for its impact on the efficiency of hyperfractionated radiation therapy performed in patients with glioblastoma and anaplastic astrocytoma of the brain. A total of 35 patients (26 and 9 patients with glioblastoma and anaplastic astrocytoma, respectively) were followed up. Radiation therapy was performed, by using a total focal dose of 65 Gy in 2 steps or a single dose of 1.

[Increasing the effectiveness of skin cancer T(2-3) N0M0 radiotherapy by use of radiosencibilizers].

The paper presents an attempt to increase the effectiveness of radiotherapy of locally advanced skin cancer by use of radiomodifiers. With this aim the researchers used metronidozol (MZ) and low-intensive laser emission (LILE), whoes radiosensibilizing activity is based on overcoming radioresistance of tumor hypoxic cell fraction. In order to increase MZ concentration in the tumor and eleminate its toxic effect the authors developed a new radiosensibilization technique, implying local use of a drug applicator.

Faster dissociation: measured rates and computed effects on barriers in aryl halide radical anions.

Carbon-halogen bond dissociation rates for a series of aryl halide radical anions (ArX-: X = Cl, Br) in NMP were measured at room temperature by pulse radiolysis with 10-11 s time resolution. To obtain accurate dissociation rates, care was taken to measure and correct for competing decay channels. The observed rates correlated well with activation energies computed in the gas phase by density functional (DFT) calculations.

[A comparative analysis of the brain computer tomography in patients with acromegaly before and after gamma-therapy].

The data given in the paper suggest that X-ray computed tomography is highly effective in evaluating the characteristics of pituitary adenomas in acromegaly and in revealing the changes caused in the pituitary adenoma by gamma-ray teletherapy. The use of brain computed tomography yielded data on the main X-ray criteria to be used in the follow-up of patients undergone radiation therapy for acromegaly.

[An experience with combined therapy of radiation and Bonephos for osteolytic metastases of breast cancer].

A new procedure of conservative treatment (radiation + benephos) is suggested to improve the quality of life of cancer patients with osteolytic metastases. Radiation regimen, dosage, benephos administration methods and characteristics of combined therapy are discussed. The procedure was tested in the course of the treatment of 21 breast cancer patients with osteolytic metastases.

[Differential diagnosis and treatment of metatypic cancer].

Fifty one patients with metatypic carcinoma (MC), 10 with basalioma, and 10 with squamous cell carcinoma were clinically and immuno-morphologically studied. There were great differences in the localization of basal cell antigen in the epidermis during MC, basalioma, squamous carcinoma of the skin. Expression of fixed immunoglobulins A, M, G in tumor tissues revealed no significant differences.

[Prognostic problems in the oncology clinic].

The purpose of this paper is to consider a number of biological and clinicomorphological signs of human tumors which influence the prediction of a course of disease as well as prognosis of a tumor response to radiation exposure. Analysis of the literature has shown that some factors of quite a favourable course of a tumor process are likely to be the signs of clinical radioresistance of the tumor. A strong possibility of individual prognosis of a tumor response to radiation therapy was shown for oropharyngeal and stomach tumors even at its onset, guided by change in the level of their proliferative activity, determined with an indirect immunofluorescent rapid method.

[Prospects of development of radiotherapy in an oncological clinic].

It is believed that new anticancer potential of radiotherapy lies in further research efforts in the fields of: clinical radiobiology, utilization of the last developments in radiological equipment, overall high quality of radiological service. Research in radiobiology should be aimed at the design of nonstandard dose fractionation, introduction of various modifiers and their combinations, prediction of individual responses of the tumor to ionizing radiation. First-hand clinical data on 3000 cases support the promise of such approach.

[Present trends in the development of radiotherapy].

New potentialities of radiotherapy of cancer patients are associated with three scientific directions: investigations in clinical radiology, the use of advantages of radiation advanced technology and guarantees of therapeutic quality. The first direction includes scientifically substantiated regimens of non-classic dose fractionation, various radiomodifiers and their combinations, and individual prognosis of a tumor response to ionizing radiation. This direction based on 3000 cases, holds promise.

[Approaches to predicting the reaction of human tumors to radiotherapy].

Immunofluorescent method using anti-thymidine antibodies was employed to assess proliferative activity of 217 human tumors including oropharyngeal, esophageal, gastric, rectal and lung cancer. The activity was evaluated before and, in 38 neoplasms, in the course of radiotherapy. It was shown that changes in the proliferative activity of oropharyngeal and gastric malignancies observed early in the course of radiation treatment may serve for predicting response.

[Nontraditional fractionation of doses of ionizing radiation in clinical practice].

Various types of non-routine dose fractionation were used in 2062 patients with malignant tumors of different sites. The conclusion was that superfractionation was more preferable for tumors with a high proliferative pool, with fast growth rates, marked radiosensitivity. It ensures the protection of normal tissues without a decrease or even with an increase in an antitumor effect.

[Percutaneous-supracutaneous ligation of the veins in the complex surgical treatment of varicose veins].

The proposed method of percutaneous-supracutaneous ligation in combination with the method of Troyanov--Trendelenburg--Bebkock was used in operation on 233 patients. Long-term results were studied in 125 patients. Excellent results were obtained in 98 patients, good results-in 27 patients.

[Use of the indicators of the proliferative activity of tumors of the oropharyngeal area as qualitative prognostic criteria of the radiotherapy].

Labeling index (LI) and growth fraction (GF) values were studied over time using biopsy specimens from patients with oropharyngeal cancer. The comparison of laboratory findings with tumor clinical response showed that a significant factor determining the tumor radiation reaction was the degree of LI and GF decrease during radiotherapy rather than their basal values. A favourable prognostic sign was a drop down to 0 or a sharp decrease in LI and GF values indicating a high tumor radiosensitivity, and enabling one to continue radiotherapy according to the radical program.