Publications by authors named "Polcwiartek C"
Article Synopsis
- The study aimed to determine if high levels of high-sensitivity troponin-T (hs-TnT) in patients with paroxysmal supraventricular tachycardia (PSVT) but no known cardiovascular disease increase the risk of death.
- Researchers reviewed data from 1,203 patients hospitalized from 2013 to 2020, finding that 65.8% had elevated hs-TnT levels.
- Results showed significantly higher short-term mortality (within 30 days) for patients with elevated hs-TnT, but long-term mortality (31-365 days) differences were not significant and may need further study.
Article Synopsis
- This study examined cardiovascular screening in patients with ANCA-associated vasculitis (AAV) and found higher rates of ECG abnormalities compared to matched controls.
- A total of 1431 AAV patients were analyzed, revealing a significant link between major ECG abnormalities and increased cardiovascular mortality risk.
- The findings suggest incorporating ECG assessments into regular care for AAV patients to better manage their cardiovascular health.
Patients with severe mental illness (SMI) including schizophrenia and bipolar disorder die on average 15-20 years earlier than the general population often due to sudden death that, in most cases, is caused by cardiovascular disease. This state-of-the-art review aims to address the complex association between SMI and cardiovascular risk, explore disparities in cardiovascular care pathways, describe how to adequately predict cardiovascular outcomes, and propose targeted interventions to improve cardiovascular health in patients with SMI. These patients have an adverse cardiovascular risk factor profile due to an interplay between biological factors such as chronic inflammation, patient factors such as excessive smoking, and healthcare system factors such as stigma and discrimination.
View Article and Find Full Text PDFThe electrocardiogram (ECG) is a non-invasive diagnostic tool holding significant clinical importance in the diagnosis and risk stratification of cardiac disease. However, access to large-scale, population-based digital ECG data for research purposes remains limited and challenging. Consequently, we established the Danish Nationwide ECG Cohort to provide data from standard 12-lead digital ECGs in both pre- and in-hospital settings, which can be linked to comprehensive Danish nationwide administrative registers on health and social data with long-term follow-up.
View Article and Find Full Text PDFAim: Patients with peripheral artery disease (PAD) represent a high-risk population with increased morbidity and mortality. We aimed to examine trends in myocardial infarction (MI), PAD and adverse clinical outcomes from years 2000 to 2019.
Methods: This nationwide Danish-based registry study included all patients with MI from years 2000-2019.
Article Synopsis
- The study investigated the long-term prognosis of patients suspected of having acute coronary syndrome (ACS) based on serial high-sensitivity troponin-I (hsTnI) measurements during hospitalization from 2012 to 2019.
- A total of 20,609 individuals were analyzed, revealing that those with persistently elevated hsTnI levels had the highest mortality rates (8.0% within 30 days and 11.1% within 365 days), while those with normal levels had much lower rates (0.5% and 2.6%, respectively).
- Changes in hsTnI concentration, particularly rising levels, could indicate higher mortality risk, especially for those with more than a 50%
Data on temporal trends in guideline-based medical and device therapies in real-world chronic heart failure (HF) patients are lacking. Register-based nationwide follow-ups of temporal trends in characteristics, guideline-recommended therapies, one-year all-cause mortality, and HF rehospitalizations in incident HF patients in Denmark during 1996-2019. Among 291,720 incident HF patients, the age at the onset of HF was stable over time.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to determine if patients with ANCA-associated vasculitis (AAV) are at a higher risk for cardiovascular disease before being diagnosed with AAV.
- Researchers used data from Danish registries, matching 2371 AAV patients with 7113 controls, and analyzed various cardiovascular outcomes over different timeframes leading up to the diagnosis.
- The findings revealed that AAV patients experienced significantly higher rates of cardiovascular issues, especially within a month prior to diagnosis, highlighting the need for clinicians to monitor cardiovascular health early in these patients.
Background: Patients with schizophrenia have an increased prevalence of risk factors for peripheral artery disease (PAD) and is expected to have an increased prevalence of PAD. PAD can be detected utilizing toe-brachial index (TBI) which screens for vascular pathology proximal to the toes.
Methods: Using a cross-sectional design, we defined the subpopulations: (1) Patients diagnosed with schizophrenia less than 2 years before inclusion (SCZ < 2), (2) Psychiatric healthy controls matched to subpopulation 1 on sex, age, and smoking status, and (3) Patients diagnosed with schizophrenia 10 or more years before inclusion (SCZ ≥ 10).
Study Objective: This study investigated whether schizophrenia and the duration of schizophrenia were associated with cardiovascular autonomic neuropathy (CAN) by using heart rate variability (HRV) as a marker.
Design: Cross-sectional study.
Setting: The examinations were conducted at the Centre for Psychosis Research and at the Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Background: The electrocardiographic (ECG) marker P terminal force V1 (PTFV1) is generally perceived as a marker of left atrial pathology and has been associated with atrial fibrillation or flutter (AF).
Objective: The purpose of this study was to determine the association between PTFV1 components (duration and amplitude) and incident AF and stroke/transient ischemic attack (TIA).
Methods: The study included patients with an ECG recorded at the Copenhagen General Practitioners Laboratory in 2001 to 2011.
Aim: This study analyzed time trends in the use of coronary procedures, guideline-based drugs, and 1-year all-cause and presumed cardiovascular mortality (CV) following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD).
Method: Using Danish registries 497 patients with ACS and BD in the period 1996-2016 were matched 1:2 on age, sex and year of ACS to patients without preexisting psychiatric disease.
Results: Patients with BD and ACS received fewer coronary angiography (CAG) compared to psychiatric healthy controls (PHC).
Objectives: To examine long-term cardiovascular outcomes and temporal trends among patients with ANCA-associated vasculitis (AAV) using Danish nationwide registries.
Methods: Using a cohort design, we examined patients with granulomatosis with polyangiitis (ICD-10: DM31.3) and microscopic polyangiitis (ICD-10: DM3.
Background: Although troponin elevation is associated with worse outcomes among patients with coronavirus disease 2019 (COVID-19), prognostic implications of serial troponin testing are lacking. We investigated the association between serial troponin measurements and adverse COVID-19 outcomes.
Methods: Using Danish registries, we identified COVID-19 patients with a high-sensitivity troponin measurement followed by a second measurement within 1-24 h.
Unlabelled: Conflicting results have been reported regarding the association between antidepressant use and out-of-hospital cardiac arrest (OHCA) risk. We investigated whether the use of antidepressants is associated with OHCA.
Methods: We conducted a nationwide nested case-control study to assess the association of individual antidepressant drugs within drug classes with the hazard of OHCA.
Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction.
Objectives: The aim of this study was to examine the risk for myocardial infarction in patients with gastrointestinal (GI) cancer treated with 5-FU compared with age- and sex-matched population control subjects without cancer (1:2 ratio).
Article Synopsis
- The study examined complications within 30 days of first-time catheter ablation for atrial fibrillation (AF) in patients aged ≥ 75 years compared to those aged 65-74 years.
- No significant difference in the rate of complications, including cardiac issues and death, was found between the two age groups, indicating similar safety profiles.
- Additionally, there was no notable difference in one-year AF relapse rates, suggesting that older patients do not face higher risks or reduced effectiveness from the procedure compared to younger patients.
Temporal trends in patient characteristics, presumed causes, and outcomes following cardiogenic shock between 2005 and 2017: a Danish registry-based cohort study.
Eur Heart J Acute Cardiovasc Care
December 2021
Aims: Most cardiogenic shock (CS) studies focus on acute coronary syndrome (ACS). Contemporary data on temporal trends in patient characteristics, presumed causes, treatments, and outcomes of ACS- and in particular non-ACS-related CS patients are sparse.
Methods And Results: Using nationwide medical registries, we identified patients with first-time CS between 2005 and 2017.
Background: Patients with severe mental illness (SMI) including schizophrenia, bipolar disorder, and severe depression have earlier onset of cardiovascular risk factors, predisposing to worse future heart failure (HF) compared with the general population. We investigated associations between the presence/absence of SMI and long-term HF outcomes.
Methods: We identified patients with HF with and without SMI in the Duke University Health System from 2002 to 2017.
Background: QRS duration and morphology including left bundle branch block (LBBB) are the most widely used electrocardiogram (ECG) markers for assessing ventricular dyssynchrony and predicting heart failure (HF). However, the vectorcardiographic QRS area may more accurately identify delayed left ventricular activation and HF development.
Objective: We investigated the association between QRS area and incident HF risk in patients with LBBB.
Objective: To compare the hazard for all-cause mortality and mortality due to heart failure (HF) between valproate (VPA) and levetiracetam (LEV)/lamotrigine (LTG) users in patients aged ≥ 65 with comorbidities of epilepsy and HF.
Methods: This was a cohort study using Danish registers during the period from January 1996 to July 2018. The study population included new users of LTG, LEV or VPA.
Background: Coronary heart disease (CHD) is a major cause of increased mortality rates in patients with schizophrenia. Moreover, coronary artery calcium (CAC) score is associated with CHD. We hypothesized that patients with schizophrenia have more CAC than the general population and aimed to investigate the CAC score in patients with schizophrenia compared to norms based on the general population.
View Article and Find Full Text PDFObjective: With hepatic steatosis (HS) being an established risk factor for CVD in the general population, it may also be a predictor of CVD in patients with schizophrenia. The aim of the present study was to investigate if time since schizophrenia diagnosis, body mass index (BMI), sex, metabolic syndrome, alcohol use, smoking, alanine transaminase (ALT), and body fat percentage (as measured by bioelectrical impedance) were associated with HS, determined by computed tomography (CT), in a population of patients diagnosed with schizophrenia.
Methods: Moderate to severe HS (40 CT Hounsfield units as threshold) was determined utilizing non-contrast enhanced CT.