Design of immunoassay based biosensor platforms for SARS-CoV-2 detection using highly specific monoclonal antibodies.

The global expand of SARS-CoV-2 has highlighted the importance of early and rapid detection to control the spread of a pandemic. In this study, specific and high-affinity monoclonal antibodies (mAbs) were developed against the conserved nucleocapsid protein of the virus among variants. Appropriate antibody pairs were selected to develop a lateral flow immunoassay (LFIA) and an unconventional application of an amperometric biosensor using unmodified screen-printed electrodes and external magnetic bead preparation.

Mental health service utilization among patients followed up in tertiary HIV/AIDS clinics in Turkey: A need for integrated care.

Objectives: Mental health (MH) care for people living with HIV (PLWH) emerges as an important unmet need, yet there are no integrated HIV-MH clinics in Turkey. Our aim is to determine MH service use and its associated factors in PLWH followed up in the HIV/AIDS outpatient clinics in Istanbul/Turkey.

Methods: A cross-sectional study was conducted at the HIV/AIDS outpatient clinics of the Infectious Diseases (ID) departments in hospitals affiliated with the ACTHIV-IST Study Group.

Assessment of Acrylamide Levels by Advanced Molecularly Imprinted Polymer-Imprinted Surface Plasmon Resonance (SPR) Sensor Technology and Sensory Quality in Homemade Fried Potatoes.

This study evaluated acrylamide (AA) levels and various quality parameters in homemade fried potatoes prepared in different sizes by integrating principles from the Slow Food Movement with advanced sensor technology. To this aim, a surface plasmon resonance (SPR) sensor based on a molecularly imprinted polymer (MIP) was first developed for the determination of AA in homemade fried potatoes at low levels, and the AA levels in the samples were established. First of all, monolayer formation of allyl mercaptane on the SPR chip surface was carried out to form double bonds that could polymerize on the chip surface.

Exploring the potential of digital therapeutics: An assessment of progress and promise.

Digital therapeutics (DTx), a burgeoning subset of digital health solutions, has garnered considerable attention in recent times. These cutting-edge therapeutic interventions employ diverse technologies, powered by software algorithms, to treat, manage, and prevent a wide array of diseases and disorders. Although DTx shows significant promise as an integral component of medical care, its widespread integration is still in the preliminary stages.

The relationship of psychiatric comorbidities and symptoms, quality of life, and stigmatization in patients with epilepsy.

Objective: Research around the frequency of psychiatric diseases and psychosocial consequences caused by seizures and stigmatization in patients with epilepsy is important, in terms of multidimensional evaluation of the condition, increasing quality of life, and controlling the frequency of seizures. This prospective study aimed to evaluate relationship between comorbid psychiatric diseases and clinical and sociodemographic data, patients' quality of life and perceived stigma in patients with epilepsy.

Methods: In this prospective single-center study, we evaluated clinical and demographic data, and characteristics of epilepsy.

Natural Orifice Specimen Extraction as a Promising Alternative for Minilaparotomy in Bowel Resection Due to Endometriosis: A Systematic Review and Meta-Analysis.

Objective: This study focuses on evaluating the effectiveness, safety and efficacy of 2 surgical tissue extraction methods for treating bowel endometriosis: natural orifice specimen extraction (NOSE) and minilaparotomy.

Data Sources: A systematic search was conducted in MedLine, Embase, and Cochrane Library databases in October 2023, without date restrictions.

Methods Of Study Selection: This study included studies that directly compared NOSE and minilaparotomy in colectomy patients due to endometriosis.

Can platelet activation markers predict preeclampsia and/or its severity?

Objective: This study aimed to evaluate the value of platelet activation markers in predicting preeclampsia and its severity. Preeclampsia is a serious pregnancy complication that affects 3-5% of pregnancies and can lead to significant morbidity and mortality for both the mother and the fetus.

Methods: The study included 99 patients diagnosed with preeclampsia and 60 healthy pregnant women as a control group.

Fetal Cytomegalovirus Infection in the Absence of Maternal Cytomegalovirus-IgM Seropositivity.

The aim of this study was to evaluate maternal serological status and fetal sonographic findings of Cytomegalovirus (CMV) infection. This is a retrospective study performed at Perinatology Department of Istanbul Başakşehir Çam and Sakura City Hospital. A computerized search was conducted to identify cases who underwent prenatal diagnosis of fetal CMV infection between September 2020 and December 2023.

Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast.

Exit from mitosis is brought about by dramatic changes in the phosphoproteome landscape. A drop in Cyclin-dependent kinase (Cdk) activity, the master regulatory kinase, and activation of counteracting phosphatases such as Cdc14 in budding yeast, results in ordered substrate dephosphorylation, allowing entry into a new cell cycle and replication licensing. In meiosis however, two cell divisions have to be executed without intermediate DNA replication, implying that global phosphorylation and dephosphorylation have to be adapted to the challenges of meiosis.

A nivalenol imprinted quartz crystal microbalance sensor based on sulphur-incorporating cobalt ferrite and its application to rice samples.

Nivalenol as a mycotoxin pesticide is toxic to humans and animals and causes major health problems including hemorrhage, anemia, and vomiting. Thus, the need for fast and reliable analytical systems in terms of the management of health risks resulting from nivalenol exposure has increased in recent years. The aim of this study involved a novel molecularly imprinted quartz crystal microbalance sensor preparation based on sulphur-incorporating cobalt ferrite for nivalenol detection in rice samples.

Fenpicoxamid-Imprinted Surface Plasmon Resonance (SPR) Sensor Based on Sulfur-Doped Graphitic Carbon Nitride and Its Application to Rice Samples.

This research attempt involved the development and utilization of a newly designed surface plasmon resonance (SPR) sensor which incorporated sulfur-doped graphitic carbon nitride (S-g-CN) as the molecular imprinting material. The primary objective was to employ this sensor for the quantitative analysis of Fenpicoxamid (FEN) in rice samples. The synthesis of S-g-CN with excellent purity was achieved using the thermal poly-condensation approach, which adheres to the principles of green chemistry.

Salmonella enterica serotypes isolated for the first time in laying hens, and their susceptibility to antibiotics.

In this study, a total of 323 drag swab samples were taken from laying hen fresh feces from 3 different provinces (Kırklareli, Edirne, and Tekirdağ), which are located in the European part of Türkiye. According to the ISO 6579: 2002 method, 17.3% of the samples were found positive for Salmonella.

Relationship between Psychological Resilience, Perceived Stress, Death Anxiety and Progression of Disease in Individuals with COVID-19.

Introduction: This study examines the association between perceived stress, death anxiety, psychological resilience and the sociodemographic and clinical features of patients with Coronavirus Disease 2019 (COVID-19).

Methods: 304 patients with COVID-19 diagnosis, who were admitted to İstanbul University İstanbul Faculty of Medicine Hospital "COVID-19 Patients Monitoring Center" were recruited. No sample selection was made, all the patients who were followed up and treated in the center were included.

Neuromuscular disease genetics in under-represented populations: increasing data diversity.

Neuromuscular diseases (NMDs) affect ∼15 million people globally. In high income settings DNA-based diagnosis has transformed care pathways and led to gene-specific therapies. However, most affected families are in low-to-middle income countries (LMICs) with limited access to DNA-based diagnosis.

A novel electrochemical detection method for butylated hydroxyanisole (BHA) as an antioxidant: a BHA imprinted polymer based on a nickel ferrite@graphene nanocomposite and its application.

A novel electrochemical detection method based on a nickel ferrite@graphene (NiFeO@Gr) nanocomposite-containing molecularly imprinted polymer (MIP) was developed for the sensitive determination of butylated hydroxyanisole (BHA). After successful completion of the nanocomposite production under hydrothermal conditions, the NiFeO@Gr nanocomposite and a novel molecularly imprinted sensor based on the NiFeO@Gr nanocomposite were characterized using microscopic, spectroscopic and electrochemical techniques. According to the characterization results, the synthesis of the core-shell type NiFeO@Gr nanocomposite with high purity and efficiency has been proved to be successful.

Assessment of D-dimer levels in pregnant women diagnosed with COVID-19: A case-control study.

Objective: We aimed to evaluate D-dimer levels in pregnant women diagnosed with COVID-19.

Methods: This single-center study was carried out in a tertiary center hospital serving as a pandemic hospital. 151 pregnant women with COVID-19 diagnosis were included as the study group, and 70 healthy pregnant women as the control group.

A novel molecular imprinted QCM sensor based on MoSNPs-MWCNT nanocomposite for zearalenone determination.

Zearalenone (ZEN) is a mycotoxin that has a carcinogenic effect and is often found at a high rate in frequently consumed foods. In this study, a characteristic molecular imprinted quartz crystal microbalance (QCM) sensor based on molybdenum disulfide nanoparticle (MoSNPs)-multiwalled carbon nanotube (MWCNT) nanocomposite (MoSNPs-MWCNTs) is presented for selective determination of ZEA in rice samples. Firstly, molybdenum disulfide nanoparticle (MoSNP)-multiwalled carbon nanotube nanocomposites were characterized by using microscopic, spectroscopic, and electrochemical techniques.

Association of maternal serum Netrin-1 and Netrin-4 levels with placenta accreta spectrum.

Objective: This study aimed to evaluate maternal serum Netrin-1 and Netrin-4 levels in pregnancies complicated with placenta accreta spectrum.

Patients And Methods: This cross-sectional study enrolled 49 pregnant women with the diagnosis of placenta accreta spectrum as the study group. Gestational age-matched 30 uncomplicated pregnant women with prior cesarean delivery and normal placentation were randomly selected as the control group.

Graphene quantum dots incorporated NiAlO nanocomposite based molecularly imprinted electrochemical sensor for 5-hydroxymethyl furfural detection in coffee samples.

5-Hydroxymethyl furfural (HMF) is an intermediate produced by dehydrating sugars, such as fructose, sucrose, and glucose, in an acidic medium or during the Maillard reaction. It also occurs due to the storage of sugary foods at inappropriate temperatures. In addition, HMF is seen as a quality criterion in products.

Evaluation of Perinatal and Neonatal Outcomes of Syrian Refugees Compared to Turkish Population: A Snapshot During the COVID-19 Pandemic.

Background: The perinatal and neonatal outcomes of Syrian refugees during the coronavirus disease 2019 (COVID-19) pandemic are unknown. Therefore, in this study, we aimed to evaluate these outcomes.

Methods: Turkish (n = 303) and Syrian refugees (n = 303) who delivered in our hospital between June 1, 2020 and December 31, 2020 were included in the study.

Determinants of participation in cardiac telerehabilitation during the first surge of COVID-19.

Background: Participation rates in cardiac rehabilitation (CR) are low. In multiple trials, telerehabilitation (TR) has been demonstrated to be effective. Still, real-life evidence is scarce.

The budding yeast GSK-3 homologue Mck1 is an essential component of the spindle position checkpoint.

The spindle position checkpoint (SPOC) is a mitotic surveillance mechanism in that prevents cells from completing mitosis in response to spindle misalignment, thereby contributing to genomic integrity. The kinase Kin4, one of the most downstream SPOC components, is essential to stop the mitotic exit network (MEN), a signalling pathway that promotes the exit from mitosis and cell division. Previous work, however, suggested that a Kin4-independent pathway contributes to SPOC, yet the underlying mechanisms remain elusive.

A new and more effective feticide technique in late termination of pregnancy: potassium chloride injection into the interventricular septum of the fetal heart.

Objective: This study sought to compare the efficacy and outcomes of fetal intracardiac intraventricular and interventricular septal potassium chloride (KCl) injections during the induced fetal demise process in a cohort of pregnant women with severe fetal abnormality who opted for late termination of pregnancy (TOP).

Materials And Methods: This study consisted of 158 pregnant women who requested late TOP for severe fetal abnormality between 22 and 36 weeks of pregnancy. Participants were randomly assigned with the simple randomization procedure to one of two feticide procedure groups: the intraventricular KCl injection group and the interventricular septal KCl administration group.