Development of Lacosamide-loaded In-Situ Gels through Experimental Design for Evaluation of Ocular Irritation In Vitro and In Vivo.

Lacosamide (LCM) selectively increases the slow inactivation of voltage-gated sodium channels (VGSCs) and is a N-methyl D-aspartate acid (NMDA) receptor glycine site antagonist. Therefore, it can be used in dryness-related hyperexcitability of corneal cold receptor nerve terminals. Ocular in-situ gels remain in liquid form until they reach the target site, where they undergo a sol-gel transformation in response to specific stimuli.

A study on the mechanical and radiation shielding characteristics of concrete samples reinforced with brass alloy and boron carbide.

In this study, the gamma radiation shielding properties of concrete samples reinforced with 10%, 20%, 30%, 40% and 50% of the cement weight of brass alloy were investigated. To test gamma shielding performance of the samples, mass and linear attenuation coefficients, half and tenth value layers, effective atomic number and radiation protection efficiency parameters were determined experimentally, theoretically and Monte Carlo simulations (GEANT4 and FLUKA). The studies were performed at 11 different gamma energies that range from 59.

Determining the relationship between stigmatization and social support in tuberculosis patients.

Background & Aim: It is aimed to analyze the relationship between stigmatization levels and social support perceptions of tuberculosis patients.

Methods & Materials: Research data are collected using socio-demographic information form, Stigmatization Scale in Patients with Tuberculosis and Multidimensional Social Support Scale.

Results: 85.

Investigation of Gamma Ray Shielding Characteristics of Binary Composites Containing Polyester Resin and Lead Oxide.

Ionizing radiation plays an essential role across various fields but also poses significant health risks, requiring effective shielding solutions. This study focuses on the photon shielding properties of PbO-reinforced composites, specifically PbO-0, PbO-2, PbO-4, PbO-6, PbO-8, and PbO-10, through experimental measurements of photon energies ranging from 59.5 keV to 1408.

Antiviral effect of cannabidiol on K18-hACE2 transgenic mice infected with SARS-CoV-2.

The aim of this study was to determine the antiviral activity of cannabidiol (CBD) against SARS-CoV-2 infection. CBD is the second most studied cannabinoid obtained from Cannabis plants. We investigated the potential use of CBD, which has so far proven to have a positive effect on different diseases, in the SARS-CoV-2 infection.

Validity and reliability of the Six-Minute Pegboard Ring Test for assessing functional capacity and upper limb function in persons with multiple sclerosis.

Background: The timed walk test is essential for assessing the functional capacity of persons with multiple sclerosis (MS). When a decline in ambulation ability and loss of function in the later stages of MS is observed, it is imperative to utilize alternative methods for measuring functional capacity.

Objective: To investigate the validity and reliability of the Six-Minute Pegboard Ring Test (6PBRT) in persons with MS.

Gingerol containing polymeric nanofibers: a healing touch for accelerated wound recovery.

Objective: In the current research, 6-gingerol (GA)-loaded were developed, and their potential usage in wound healing was evaluated.

Significance: This study investigates the effectiveness of nanofibrous membranes composed of sodium alginate (SA), poly(vinyl alcohol) (PVA), and 6-gingerol (GA) as delivery systems for anti-inflammatory agents in the context of wound dressings.

Methods: GA-loaded SA/PVA nanofiber was prepared using electrospinning.

The distribution and chemosensory responses of pharyngeal taste buds in the sea lamprey Petromyzon marinus.

Little is known about the chemosensory system of gustation in sea lampreys, basal jawless vertebrates that feed voraciously on live prey. The objective of this study was to investigate taste bud distribution and chemosensory responses along the length of the pharynx in the sea lamprey. Scanning electron microscopy and immunocytochemistry revealed taste buds and associated axons at all six lateral pharyngeal locations between the seven pairs of internal gill pores.

Detailed Analysis of Gamma-Shielding Characteristics of Ternary Composites Using Experimental, Theoretical and Monte Carlo Simulation Methods.

Ionizing radiation is vital in various fields but poses health risks, necessitating effective shielding. This study investigated the photon-shielding properties of polyester-based ternary composites with barite (BaSO) and tungsten (W) using experimental methods, theoretical calculations, and Monte Carlo simulations for energies between 81 keV and 1332.5 keV.

Determination of Compassion and Compassion Fatigue in Intensive Care Nurses.

Introduction: Compassion is defined as the sadness felt by a living thing or a person due to a negative situation. Compassion fatigue describes emotional, physical, social and spiritual exhaustion or a decrease in these feelings. The concept of compassion, which is at the center of nursing, may be related to compassion fatigue in nurses.

Accurate Free Energies of Aqueous Electrolyte Solutions from Molecular Simulations with Non-polarizable Force Fields.

Non-polarizable force fields fail to accurately predict free energies of aqueous electrolytes without compromising the predictive ability for densities and transport properties. A new approach is presented in which (1) TIP4P/2005 water and scaled charge force fields are used to describe the interactions in the liquid phase and (2) an additional Effective Charge Surface (ECS) is used to compute free energies at zero additional computational expense. The ECS is obtained using a single temperature-independent charge scaling parameter per species.

Formulation of hesperidin-loaded in situ gel for ocular drug delivery: a comprehensive study.

Background: Allergic conjunctivitis is one of the most common eye disorders. Different drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus sinensis L.

The role of oxidative stress and inflammation biomarkers in pre- and postoperative monitoring of prostate cancer patients.

Introduction: Prostate Cancer (PC) is a global health concern affecting men worldwide. Oxidative stress is believed to contribute to the initiation of early-stage PC lesions. Additionally, inflammation has long been acknowledged as a factor in the development of PC.

Multi-Stage Learning Framework Using Convolutional Neural Network and Decision Tree-Based Classification for Detection of DDoS Pandemic Attacks in SDN-Based SCADA Systems.

Supervisory Control and Data Acquisition (SCADA) systems, which play a critical role in monitoring, managing, and controlling industrial processes, face flexibility, scalability, and management difficulties arising from traditional network structures. Software-defined networking (SDN) offers a new opportunity to overcome the challenges traditional SCADA networks face, based on the concept of separating the control and data plane. Although integrating the SDN architecture into SCADA systems offers many advantages, it cannot address security concerns against cyber-attacks such as a distributed denial of service (DDoS).

Ensemble Learning Framework for DDoS Detection in SDN-Based SCADA Systems.

Supervisory Control and Data Acquisition (SCADA) systems play a crucial role in overseeing and controlling renewable energy sources like solar, wind, hydro, and geothermal resources. Nevertheless, with the expansion of conventional SCADA network infrastructures, there arise significant challenges in managing and scaling due to increased size, complexity, and device diversity. Using Software Defined Networking (SDN) technology in traditional SCADA network infrastructure offers management, scaling and flexibility benefits.

Single and double injection paravertebral block comparison in reduction mammaplasty cases: a randomized controlled study.

Background: This study compares the analgesic effects and dermatomal blockade distributions of single and double injection bilateral thoracic paravertebral block (TPVB) techniques in patients undergoing reduction mammaplasty.

Methods: After obtaining ethics committee approval, 60 patients scheduled for bilateral reduction mammaplasty were included in the study. Preoperatively, the patients received one of single (Group S: T3-T4) or double (Group D: T2-T3 & T4-T5) injection bilateral TPVBs using bupivacaine 0.

Alexithymia and Forgiveness Levels of Forensic Psychiatric Patients.

The current cross-sectional study was performed to examine levels of alexithymia and forgiveness in forensic psychiatric patients. Data were collected between March 2022 and August 2022 at a high-security forensic psychiatric hospital affiliated with a city hospital in Turkey. A personal information form prepared by the researchers, the Toronto Alexithymia Scale, and the Heartland Forgiveness Scale were used to obtain data.

A comparative analysis of the efficacy and safety of mini-percutaneous nephrolithotomy performed in the supine and prone positions for the treatment of pediatric kidney stones: a single-center experience.

Mini-percutaneous nephrolithotomy (MPCNL), which has a smaller tract size (14-20 Fr) than conventional percutaneous nephrolithotomy, has been shown to be safe and effective in pediatric patients with large and complex upper urinary tract stones. This study aimed to compare the efficacy and safety of MPCNL between the supine and prone positions in a pediatric population. The data of pediatric patients who underwent MPCNL at our center between January 2010 and March 2023 were retrospectively analyzed.

Formulation development of Lornoxicam loaded heat triggered ocular gel using factorial design.

Objective: In the current research, lornoxicam-loaded gels were developed, and their potential usage in ocular inflammation was evaluated.

Significance: Lornoxicam cyclodextrin complex prepared with hydroxypropyl methylcellulose and poloxamer P407 because of the low viscosity of gels to provide easy application. However, washing and removing it from the ocular surface becomes difficult due to the gelation formation with heat.

Could the Cerebral Involvement of COVID-19 Disease be Related to Microstructural Changes that are not Reflected in Conventional MRI Images?

In patients with COVID-19, neurodegeneration may develop before clinical symptoms appear. Diffusion-weighted (DW) MRI is an important technique for analyzing microstructural changes such as gliosis. In this study, a quantitative evaluation of microstructural changes in the brain with apparent diffusion coefficient (ADC) values in patients presenting with a headache after the COVID-19 disease was analyzed and compared.

The effect of functional remission and cognitive insight on criminal behavior in patients with schizophrenia.

Unlabelled: OBJECTıVE: This study was planned to determine the relationship of functional remission with a criminal history and determine its effect on criminal behavior in patients with schizophrenia.

Methods: This cross-sectional study was conducted with 132 patients with schizophrenia (66 with and 66 without a criminal history). Data were collected between November 2020 and April 2021 using a personal information form, the Functional Remission of General Schizophrenia (FROGS), the Taylor Crime Violence Rating Scale, the Beck Cognitive Insight Scale, and the Positive and Negative Syndrome Scale (PANSS) was used to collect data.

Single-Bud Expression Analysis of Bud Dormancy Factors in Peach.

Transcriptomic and gene expression analysis have greatly facilitated the identification and characterization of transcriptional regulatory factors and effectors involved in dormancy progression and other physiological processes orchestrated during bud development in peach and other temperate fruit species. Gene expression measurements are most usually based on average values from several or many individual buds. We have performed single-bud gene analysis in flower buds of peach across dormancy release using amplicons from the master regulatory () factors, several jasmonic acid biosynthetic genes, other genes related to flowering development, cell growth resumption, and abiotic stress tolerance.

Prediction of Heart Disease Based on Machine Learning Using Jellyfish Optimization Algorithm.

Heart disease is one of the most known and deadly diseases in the world, and many people lose their lives from this disease every year. Early detection of this disease is vital to save people's lives. Machine Learning (ML), an artificial intelligence technology, is one of the most convenient, fastest, and low-cost ways to detect disease.