ENNGene: an Easy Neural Network model building tool for Genomics.

Background: The recent big data revolution in Genomics, coupled with the emergence of Deep Learning as a set of powerful machine learning methods, has shifted the standard practices of machine learning for Genomics. Even though Deep Learning methods such as Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs) are becoming widespread in Genomics, developing and training such models is outside the ability of most researchers in the field.

Results: Here we present ENNGene-Easy Neural Network model building tool for Genomics.

Silver Diamine Fluoride and Progression of Incipient Approximal Caries in Permanent Teeth: A Retrospective Study.

The purpose of this study was to evaluate the progression of incipient approximal caries lesions in permanent teeth of children and adolescents with and without silver diamine fluoride (SDF) application. A retrospective analysis of dental records and radiographs was performed. Baseline and follow-up bitewing radiographs were evaluated and scored using International Caries Classification and Management System (ICCMS) criteria to assess lesion progression.

A Short Note about the Impact Action of a Water Jet Stabilized by a Coaxial Air Stream in the Air and Underwater.

A new original method, applying a coaxial protective airflow, was tested aiming to improve the pure water jet efficiency in surface layer removal or medium hard materials cutting or blasting. The dual action of the air flow is expected: the air co-flowing the water jet with approximately the same velocity should prevent the central jet from breaking up into tiny droplets in the near field, and simultaneously, it should support jet decomposition into big parts with enough destructive potential in the far-field. A brief survey of the relevant literature dealing with the water jet instability is presented, introducing four recognized breakup regimes.

PENGUINN: Precise Exploration of Nuclear G-Quadruplexes Using Interpretable Neural Networks.

G-quadruplexes (G4s) are a class of stable structural nucleic acid secondary structures that are known to play a role in a wide spectrum of genomic functions, such as DNA replication and transcription. The classical understanding of G4 structure points to four variable length guanine strands joined by variable length nucleotide stretches. Experiments using G4 immunoprecipitation and sequencing experiments have produced a high number of highly probable G4 forming genomic sequences.

Dissolution rate-limited absorption and complete bioavailability of roquinimex in man.

In order to investigate the bioavailability and the rate-limiting step of the absorption of roquinimex, an oral solution and a tablet formulation (Linomide(R)) were given to healthy volunteers. The study was conducted as a randomized three-period crossover study in seven male and seven female healthy volunteers. The subjects received an intravenous infusion, an oral solution and an oral tablet formulation, each of 5 mg (about 0.

Anti-angiogenic treatment with linomide as adjuvant to surgical castration in experimental prostate cancer.

Purpose: Escape from "castration inhibition," be it surgical or chemically induced, is still the major problem in prostate cancer treatment. New agents that can be given as adjuvant therapy are needed. Linomide has demonstrated both anti-tumor and anti-angiogenic activity with little toxicity in the Dunning R-3327 rat prostate tumor system.

Chromosome aberrations and pharmacokinetics in patients receiving tauromustine as either a single or a repeated dose.

Tauromustine (TCNU) is an exploratory drug that has demonstrated activity in various solid tumors. We examined chromosome aberrations and plasma levels of the drug in two groups of patients receiving either a single dose of 130 mg/m2 or 40 mg/m2 on 3 consecutive days. Peak plasma concentrations (mean +/- SD) were obtained at a similar time after both treatments, i.

The quinoline-3-carboxamide linomide inhibits angiogenesis in vivo.

Linomide (Roquinimex) has antitumor activity when given in vivo (but not when applied in vitro) that has been attributed to immune host mechanisms. Recent studies, however, suggest that Linomide may also possess antiangiogenic properties. The aim of the present study was to evaluate the antiangiogenic effect of Linomide using an intravital microscopic technique.

Determination of tauromustine and its demethylated metabolites in plasma and urine.

A sensitive, selective and precise high-performance liquid chromatographic method for simultaneous determination of tauromustine and its demethylated metabolites in plasma and urine has been developed. It is based on solid-phase extraction on C18 sorbent and separation on a semipolar column. The analytical procedure is described in detail.

Pharmacokinetics of tauromustine in cancer patients. Phase I studies.

The pharmacokinetic properties of tauromustine (TCNU) were studied in 31 cancer patients who participated in phase I trials. The patients received single oral doses of tauromustine in the range of 20-170 mg/m2. Plasma samples were taken over 24 h after administration and analysed for tauromustine by reversed-phase liquid chromatography.

Anti-tumour, toxicological and pharmacokinetic properties of a novel taurine-based nitrosourea (TCNU).

A novel nitrosourea, 1-(2-chloroethyl)-3-[2-(dimethylaminosulfonyl) ethyl]-1-nitrosourea (TCNU) tauromustine, has been investigated in a broad anti-tumour screen and, in depth toxicology and initial pharmacokinetics carried out. TCNU and its two metabolites were found to exhibit equal or better oral efficacy than that of BCNU, CCNU, MeCCNU or chorozotocin against L1210 leukemia, Walker mammary carcinoma, Lewis Lung, Harding Passey melanoma and colon carcinoma C26. The toxicological profile of TCNU after acute and 3 months treatment was similar in mice and rats to that of CCNU, with the exception that, TCNU did not cause the chronic liver disturbances found for CCNU.

[Heritability in the incidence of rudimentary teats in milk cows of the Bohemian spotted breed].

The set of 2,230 dairy cows was studied for genotype influence on the occurrence of rudimentary teats in the dairy cows of Bohemian Spotted breed. In the studied population 57.62% cows had rudimentary teats.

[Heredity of the position of rudimentary teats in cows of the Czech Spotted breed].

A characteristic effect of bulls on the distribution of rudimentary teats in their daughters was demonstrated by the study of the influence of the genotype on the location of extra teats. The comparison of the mother--daughter pairs showed that the concordance of location of a single teat either on the right or on the left between the mother and daughter was found in 86.40% of all cases, whereas discordance was found just in 13.