A Comparative Cross-Platform Analysis to Identify Potential Biomarker Genes for Evaluation of Teratozoospermia and Azoospermia.

Male infertility is a global public health concern. Teratozoospermia is a qualitative anomaly of spermatozoa morphology, contributing significantly to male infertility, whereas azoospermia is the complete absence of spermatozoa in the ejaculate. Thus, there is a serious need for unveiling the common origin and/or connection between both of these diseases, if any.

Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill.

The progress in industrialization has blessed mankind with a technologically superior lifestyle but poor management of industrial waste has in turn poisoned nature. One such chemical is carbon tetra chloride (CCl4), which is a potent environmental toxin emitted from chemical industries and its presence in the atmosphere is increasing at an alarming rate. Presence of CCl4 in human body is reported to cause liver damage through free radical mediated inflammatory processes.

A rapid and efficient DNA extraction protocol from fresh and frozen human blood samples.

Background: Different methods available for extraction of human genomic DNA suffer from one or more drawbacks including low yield, compromised quality, cost, time consumption, use of toxic organic solvents, and many more. Herein, we aimed to develop a method to extract DNA from 500 μL of fresh or frozen human blood.

Methods: Five hundred microliters of fresh and frozen human blood samples were used for standardization of the extraction procedure.

Environmental selection influences the diversity of TLR genes in ethnic Rajbanshi population of North Bengal Region of India.

Background: Toll-like receptors are the mediators of the innate immune response to pathogens. In human, this gene family regulates the inflammatory pathways and is associated with the susceptibility to infection.

Subjects And Methods: The distribution and the diversity patterns of TLR genes in Rajbanshi population ( = 85) who are the inhabitants of the Northern part of West Bengal, have been investigated in the present study.

Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal.

Background: The aim of the present study was to quantify the phytochemicals of Clerodendrum infortunatum root and correlate on the basis of phytochemicals present with other medicinal plants belonging to different families.

Methods: Various standard biochemical and spectrophotometric methods were employed to study the phytochemical status of the root of C. infortunatum.

Study of genetic diversity of KIR and TLR in the Rabhas, an endogamous primitive tribe of India.

The Rabha tribe is a little known small endogamous population belonging to Indo-mongoloid group of north-eastern India. We have analyzed 16 KIR and 5 TLR gene polymorphisms in the Rabha population of northern West Bengal, India for the first time. The observed frequencies of the KIR genes (except framework and pseudogene loci) ranged between 0.

Human migration, diversity and disease association: a convergent role of established and emerging DNA markers.

With the gradual development of intelligence, human got curious to know his origin and evolutionary background. Historical statements and anthropological findings were his primary tool for solving the puzzles of his own origin, until came the golden era of molecular markers which took no time to prove it's excellence in unveiling answers to the questions regarding the migration pattern of human across different geographical regions. As a bonus these markers proved very much beneficial in solving criminal offenses and in understanding the etiology of many dreaded diseases and to design their prevention.

Study of the KIR gene profiles and analysis of the phylogenetic relationships of Rajbanshi population of West Bengal, India.

The natural killer (NK) cells have distinct receptors called killer cell immunoglobulin-like receptors (KIR) which are responsible for regulating NK cell responses to infections and malignancy. The extensive variations in the number and type of KIR genes can be used as a tool to understand the differentiation of populations and also for tracing genetic background. In this study, we have aimed to analyze the KIR gene polymorphism in the Rajbanshi population of West Bengal, India.