Comparison of the quality of life between women undergoing medical and surgical terminations of pregnancy.

Objective: The aim of this study was to compare the relation between the quality of life, level of depression and some other psychological characteristics of women and the method (pharmacological or instrumental) they chose to terminate their pregnancy up to 49 days of amenorrhoea.

Methods: From Jan 1st, 2019 to Aug 31st, 2020 we prospectively analyzed data obtained by evaluating questionnaires from 106 women with a choice of pharmacological (faUUT) and 105 women with a choice of surgical (iUUT) termination of pregnancy. The questionnaires focused on their quality of life and other characteristics.

Comparison of groups with medical and surgical terminations of pregnancy.

Objective: The aim of this study was to compare two cohorts of subjects who underwent termination of pregnancy up to 49 days of amenorrhoea by medical (pharmacological) termination (faUUT) and surgical instrumental termination of pregnancy (inUUT).

Design: Prospective clinical study.

Setting: Department of Gynecology and Obstetrics, Charles University in Prague, 1st Faculty of Medicine, Hospital Na Bulovce.

β-Cyclodextrin duplexes that are connected through two disulfide bonds: potent hosts for the complexation of organic molecules.

New tubular host molecules, which are composed of two β-cyclodextrin macrocycles that are connected through two disulfide bonds, have been prepared by the air-promoted oxidation of 6(I),6(IV)-dideoxy-6(I),6(IV)-disulfanyl-β-cyclodextrin in aqueous solution. This reaction leads to three products: monomeric intramolecular disulfide and two dimeric species, which are termed as "non-eclipsed" and "eclipsed" cyclodextrin duplexes. Oxidation at a concentration of the starting thiol of 0.

Methyl 2-{4-chloro-2-[5-chloro-2-(2-meth-oxy-2-oxoeth-oxy)benz-yl]phen-oxy}acetate.

In the crystal structure of the title compound, C(19)H(18)Cl(2)O(6), mol-ecules are connected via weak C-H⋯π inter-actions into closely packed dimers.

2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-3-ium chloride.

In the crystal structure of the title compound, C(4)H(8)N(3)O(+)·Cl(-), N-H⋯Cl hydrogen bonds link the components into chains along [010]. In addition, weak C-H⋯Cl hydrogen bonds link the chains into a two-dimensional network perpendicular to (001).

2,17-Dichloro-8,9,10,11-tetra-hydro-19H-dibenzo[k,n][1,10,4,7]dioxadiaza-cyclo-penta-decine-7,12(6H,13H)-dione.

In the crystal structure of the title compound, C(19)H(18)Cl(2)N(2)O(4), N-H⋯O hydrogen bonds link the mol-ecules into infinite chains along the b axis. The structure also features weak C-H⋯O and C-H⋯Cl hydrogen bonds and C-H⋯π and (lone pair)⋯π inter-actions [Cl⋯centroid = 3.5871 (7) Å].

5,11,17,23,29,35-Hexa-tert-butyl-37,38,39,40,41,42-hexa-kis-(eth-oxy-carbonyl-meth-oxy)calix[6]arene acetonitrile disolvate.

In the title compound, C(90)H(120)O(18)·2CH(3)CN, the calix[6]arene has a 1,2,3-alternate conformation and possesses inversion symmetry. It crystallizes as an acetonitrile disolvate, with a half-mol-ecule of calix[6]arene and one mol-ecule of solvent in the asymmetric unit. In the crystal, the two solvent mol-ecules are enclosed in voids between the calix[6]arene mol-ecules.

10,16-Dichloro-6,20-dioxa-3,23-diaza-tetra-cyclo-[23.3.1.0.0]nona-cosa-1(29),7,9,11,14(19),15,17,25,27-nona-ene-4,22-dione methanol monosolvate.

In the title compound, C(25)H(22)Cl(2)N(2)O(4)·CH(3)OH, the macrocyclic mol-ecule adopts a slightly distorted C(2)-symmetric conformation. The macrocyclic mol-ecules are linked via N-H⋯O hydrogen bonds between the amide groups into chains extending along the [010] direction. The methanol mol-ecules bridge these chains via N-H⋯O and O-H⋯O hydrogen bonds with the formation of a two-dimensional polymeric structure parallel to (001).

1,1'-[(2,3,3a,4,5,6,7,7a-Octa-hydro-1H-1,3-benzimidazole-1,3-di-yl)bis-(methyl-ene)]bis-(1H-benzotriazole).

The cyclo-hexane ring in the title compound, C(21)H(24)N(8), adopts a chair conformation and the five-membered heterocyclic ring to which it is fused adopts a twist conformation on their common C-C bond. The substituents on the N atoms of the central five-membered heterocycle are arranged trans with respect to the central ring. The terminal benzotriazole rings are oriented at angles of 74.

4,4'-Di-tert-butyl-2,2'-[(3aRS,7aRS)-2,3,3a,4,5,6,7,7a-octa-hydro-1H-1,3-benzimidazole-1,3-di-yl)bis-(methyl-ene)]diphenol.

In the title compound, C(29)H(42)N(2)O(2), the heterocyclic ring has a twist conformation. The cyclohexane ring adopts a chair conformation. The dihedral angle between the aromatic rings is 32.

N,N,N',N'-Tetra-isobutyl-pyridine-2,6-dicarboxamide.

In the title compound, C(23)H(39)N(3)O(2), the amide O atoms are displaced by 1.020 (1) and 1.211 (1) Å from the mean plane of the central pyridine ring.

2-Amino-1,3-thia-zolium dihydrogen phosphate.

In the title compound, C(3)H(5)N(2)S(+)·H(2)PO(4) (-), the dihydrogen phosphate anions form infinite chains along [001] via short O-H⋯O hydrogen bonds. The 2-amino-thia-zolium cations inter-connect these chains into a three-dimensional network by short linear or bifurcated N-H⋯O and weak C-H⋯O hydrogen bonds.

Low-temperature superstructure of [(N,N-diisobutyl-carbamo-yl)meth-yl]oct-yl(phen-yl)phosphine oxide (CMPO).

At 120 K, the title compound, C(24)H(42)NO(2)P, crystallizes in a unit cell with a doubled a parameter compared with the room-temperature structure. There are four mol-ecules in the asymmetric unit, one of which shows extensive disorder in a 0.588 (3):0.

Tris(2-amino-1,3-thia-zolium) hydrogen sulfate sulfate monohydrate.

The centrosymmetric crystal structure of the novel semi-organic compound, 3C(3)H(5)N(2)S(+)·HSO(4) (-)·SO(4) (2-)·H(2)O, is based on chains of alternating anions and water mol-ecules (formed by O-H⋯O hydrogen bonds). The chains are inter-connected with the 2-amino-1,3-thia-zolium cations via strong N-H⋯O and weak C-H⋯O hydrogen-bonding inter-actions into a three-dimensional network.

N,N,N',N'-Tetra-ethyl-pyridine-2,6-dicarboxamide.

The title compound, C(15)H(23)N(3)O(2), crystallizes with two mol-ecules in the asymmetric unit which are linked by a C-H⋯N hydrogen bond. In the crystal, mol-ecules are connected via weak C-H⋯O and C-H⋯N hydrogen bonds between the amide O atoms and ethyl chains and between pyridine N atoms and aromatic H atoms in para positions. C-H⋯π inter-actions also occur.

3,3'-(Ethane-1,2-di-yl)bis-(6-methyl-3,4-dihydro-2H-1,3-benzoxazine).

The asymmetric unit of the title compound, C(20)H(24)N(2)O(2), contains one half-mol-ecule, which is completed by inversion symmetry. In the crystal, mol-ecular chains are formed through non-classical C-H⋯O hydrogen bonds, formed between axial H atoms of the oxazine ring and a O atom of a neighboring mol-ecule.

4,4'-Dichloro-2,2'-[imidazolidine-1,3-diylbis(methylene)]diphenol.

The imidazolidine ring in the title compound, C(17)H(18)Cl(2)N(2)O(2), adopts a twist conformation. The observed conformation is stabilized by two intra-molecular O-H⋯N hydrogen bonds, with both N atoms acting as hydrogen-bond acceptors. The phenyl substituents are aligned at 70.

2-(2-Meth-oxy-phen-yl)-1-benzofuran.

In the title compound, C(15)H(12)O(2), the dihedral angle between the aromatic ring systems is 16.67 (6)°. The methyl C atom is almost coplanar with its attached benzene ring [displacement = 0.

Bambus[n]urils: a new family of macrocyclic anion receptors.

A recently discovered anion receptor is jointed by three related macrocycles differing in the number of glycoluril units and type of substitution. The synthesis is carried out in nonpolar solvents compared to aqueous media used in the case of the original macrocycle. The size of macrocycle is controlled by a template.

(R)-2,2'-Bis[N'-(3,5-dichloro-phen-yl)ureido]-1,1'-binaphthalene chloro-form disolvate.

The title compound, C(34)H(22)Cl(4)N(4)O(2)·2CHCl(3), is a new urea based on the 1,1'-binaphthalene skeleton, which crystallizes with two mol-ecules of binaphthalene and four mol-ecules of chloro-form in the unit cell. The chloro-form solvent mol-ecules do not participate in non-covalent inter-actions and therefore, can be found in several positions. The binaphthalene mol-ecules are connected via a system of N-H⋯O hydrogen bonds between the ureido units.

5,11,17,23,29-Penta-tert-butyl-31,32,33,34,35-penta-propoxycalix[5]arene dichloro-methane hemisolvate.

The title compound, tert-butyl-propoxycalix[5]arene, C(70)H(100)O(5)·0.5CH(2)Cl(2), crystallizes as a solvate with two mol-ecules of calix[5]arene in 1,2-alternate conformations and one mol-ecule of dichloro-methane in the asymmetric unit. One tert-butyl group in one of the mol-ecules and two in the other are disordered over two positions with occupancy factors fixed at 0.

Hydro-nium perchlorate-dibenzo-18-crown-6 (1/1): monoclinic polymorph.

The asymmetric unit of the title compound, H(3)O(+)·ClO(4) (-)·C(20)H(24)O(6), contains two mol-ecules/ions of each species. Both dibenzo-18-crown-6 mol-ecules have a complexed hydro-nium ion inside their cavity with O-H⋯O and O-H⋯(O,O) links between the two species. The associated perchlorate anions also accept O-H⋯O hydrogen bonds from the hydro-nium ion.

1,4,8,11-Tetra-azoniacyclo-tetradecane diaqua-tetra-chloridomanganese(II) dichloride dihydrate.

The title compound, (C(10)H(28)N(4))[MnCl(4)(H(2)O)(2)]Cl(2)·2H(2)O, consists of isolated octa-hedral [MnCl(4)(H(2)O)(2)](2-) anions, tetra-protonated 1,4,8,11-tetra-azoniacyclo-tetradecane cations, chloride anions and water mol-ecules connected by a network of hydrogen bonds. The Mn(II) atom is situated on an inversion centre, and the 1,4,8,11-tetra-azoniacyclo-tetradecane cation is located on a mirror plane.

Unusual intramolecular bridging reaction in thiacalix[4]arene series.

Thiacalix[4]arene immobilized in the cone conformation undergoes a direct formylation reaction giving unusual products in high yields. The Duff reaction (urotropine/TFA) leads to unprecedented intramolecularly bridged compounds possessing two formyl groups on the opposite para- or para-/meta-positions. The comparison with the corresponding classical calix[4]arene analogues indicates an amazingly different reactivity of the thiacalix[4]arene system.

Uncommon regioselectivity in thiacalix[4]arene formylation.

To reveal the alternative ways for upper-rim thiacalixarene derivatization, the formylation reactions (Gross and/or Duff conditions) of the corresponding tetrapropoxythiacalix[4]arene immobilized in the 1,3-alternate conformation were systematically studied. Surprisingly, albeit using an excess of the formylation agent, only two formyl groups were introduced exclusively into the meta positions of thiacalixarene skeleton. Unexpected regioselectivity of these reactions opens the door for a unique substitution pattern in thiacalixarene chemistry.