[Prevalence of glucose metabolism disorders and thyropathies in the population of District 8 in Prague].

Based on an enquiry made by means of questionnaires sent by post, implemented in 1987 in five health communities of Prague 8, anamnestic data were obtained pertaining to glycoregulation and thyropathies from 5870 respondents. Based on these data the following conclusions were reached: 1. The prevalence of known disorders of glycoregulation, without specification, is in the population of Prague 8 7.

Urinary iodine and the state of the thyroid gland in Czech children.

In 1988 the authors examined by palpation a total of 978 13--14-year-old children (490 boys and 488 girls) from two areas with a different endemic incidence of goitre (Sedlcany area high endemic, Príbram area low endemic). By palpation in this group a non-palpable thyroid gland was found in 48.2% boys and 33.

Influence of thyroid hormone supply on EEG frequency spectrum.

In 5 patients after total thyroidectomy followed by radioiodine ablation the frequency analysis of EEG based on fast Fourier transformation was performed and the results obtained during hypothyroid state and after the substitution treatment with thyroid hormones were compared. During the hypothyroid state the most remarkable finding was the increase of percentage representation of fast frequencies in beta 1 and beta 2 bands, while such values in alpha band including a dominant frequency in that band were reciprocally decreased. After the period of treatment with triiodothyronine during which clinically euthyroid state has been achieved (i.

Prevalence of thyroid diseases in two samples of Czech population. A preliminary study.

Two preliminary pilot studies of prevalence of thyroid disorders in Central Bohemia (with mild endemy before the onset of iodine prophylaxis in 1948) were made: 1. Questionary survey of adult persons in Praha (1559 persons); 2. Clinical and laboratory investigation of 2015 employees of SKODA automobile works in Mladá Boleslav.

Some factors influencing the survival of patients with less advanced stages of differentiated thyroid cancer.

Two groups of patients with less advanced stages of differentiated thyroid cancer were followed from 2 to more than 25 years: 1. 326 patients with preventive thyroid ablation (PTA) in cases of a tumor without lymphatic and remote metastases; 2. 471 patients with lymph node syndrome.

The rational use of 201Tl scintigraphy in the evaluation of differentiated thyroid cancer.

Fifteen patients with differentiated thyroid cancer were examined following 131I thyroid ablation, of these seven were examined after radio-iodine therapy to disseminated neck cancer. They had no further radio-iodine uptake and were evaluated using a 201Tl scan. In thirteen patients there was a good correlation between the results and the clinical diagnosis, showing no uptake in seven subjects with negative clinical findings, and positive delineation of tumour tissue in the neck region in six patients.

Serum thyroglobulin determinations in patients with differentiated thyroid carcinoma.

Serum thyroglobulin levels were measured in 636 patients with differentiated thyroid carcinoma, in whom altogether 1240 determinations were performed in different phases of disease and treatment. A modified sensitive radioimmunoassay was employed using an own high-specific thyroglobulin antibody. The results showed that both the majority of patients with functioning metastases accumulating radioiodine and with non-functioning metastases which could not be detected by scanning had higher serum TG levels, compared with a group of healthy subjects.

TSH stimulation and other ways to increase the uptake in normal and tumorous thyroidal tissue.

The use of bovine TSH is still the most important means for increasing the radioiodine uptake in functionally active tissue. The increase is more marked in normal thyroid tissue (where 2.5 fold increase of the initial value can be expected); but the tumorous tissue reacts to the stimulation, though less substantially (mean increase to 1.

Thyroidectomy as a pathogenic factor in the evolution of thyroid cancer.

In a group fo 860 patients with thyroid cancers (TC), 66 were found having had thyroid surgery for benign disorder more than 5 years before the diagnosis of TC. More than 70% of these patients were operated upon 10 or more years ago. The incidence of cancers developing in thyroid postsurgical remnants could thus be estimated to 5.

[Roentgenological characteristic of pulmonary metastases in thyroid cancer in respect of its biological behaviour (author's transl)].

In metastases of the lung which must be considered as typical in cancer of the thyroid, it is possible to differentiate roentgenologically between fine and coarse nodules, the limit being approximately 10 mm. Metastases consisting of fine nodules are by no means to be considered as representing a fatal generalisation, whereas metastases with coarse nodules are frequently accompanied by other metastases distant from the primary tumour.

Radioiodide treatment of pulmonary metastases of differentiated thyroid cancer. Results and prognostic factors.

Pulmonary metastases were found in 123 out of 840 patients with thyroid cancer between 1955-1977, 87 patients with pulmonary metastases of differentiated cancer were studied in detail, including an evaluation of prognostically important factors. In 66 of them, the induction of 131I uptake in metastases was attempted, in half of them successfully. Uptake was achieved more frequently in younger subjects, in papillary cancers and in patients with fine pulmonary metastases on chest films.

The value of plasma TSH estimation and TRH stimulation test in the course of treatment of differentiated thyroid cancers.

Plasma TSH levels were measured on 114 occasions in 96 patients treated for differentiated thyroid cancer. Prior to thyroid surgery, plasma TSH levels were within the range of normal. Plasma TSH levels increased slightly following partial thyroid resection and definitely after total thyroid ablation.

Labelled amino acids in plasma of patients with thyrotoxicosis and thyroid cancer after radioiodine treatment.

The levels of total organically bound 131I, per cent of labelled iodoproteins, total labelled iodinated amino acids and a percentage of individual iodinated amino acids (thin-layer chromatography) were measured in serum of 84 patients with thyroid cancer and of 16 patients with thyrotoxicosis at 48 h after the administration of therapeutic dose of 131I. In thyrotoxic patients treated with therapeutic doses of 131I (2 to 39.6mCi; 74 to 1500 MBq) the findings were similar to normal subjects.