Publications by authors named "Pogodina A"

Article Synopsis
  • Glioblastoma (GB) is a highly aggressive brain tumor in adults with complex genetics, making it difficult to treat effectively; current therapies are limited and often ineffective.
  • This systematic review, adhering to PRISMA guidelines, analyzed studies from several databases to explore emerging treatments focused on glioblastoma stem cells and advanced drug delivery systems, culminating in 24 eligible peer-reviewed articles from an initial 755 found.
  • While the review highlights promising new therapies, it points out limitations like potential language bias, variability among studies, and reliance on preclinical models, emphasizing the need for continuous research in this complex area.
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Article Synopsis
  • - Trigeminal neuralgia (TN) is a painful condition treated through various surgical methods, including microvascular decompression (MVD) and stereotactic radiosurgery such as Gamma Knife.
  • - MVD offers substantial long-term relief but has varying recurrence rates, while GKRS provides good initial pain relief but may require repeat procedures over time.
  • - The review stresses the need for personalized treatment plans and careful patient selection to improve outcomes, as each surgical option has its own risks and effectiveness depending on the patient's specific situation.
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Adolescence is a critical period for the onset of eating disorders, which affect an adolescent's diet and can have adverse and long-term health consequences. The relationship between the risk of eating disorders and the diet of Russian adolescents has been little studied. of the research was to characterize the relationship between the risk of eating disorders and dietary patterns in a sample of Russian schoolchildren.

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Chronic pain affects a substantial portion of the global population, significantly impacting quality of life and well-being. This condition involves complex mechanisms, including dysfunction of the autonomic nervous system, which plays a crucial role in pain perception. The insula, a key brain region involved in pain processing, plays a critical role in pain perception and modulation.

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Understanding the principles underlying the stability and sustainability of the gut microbiome of adolescents with normal weight and obesity will make it possible to implement a personalized approach to the correction of metabolic disorders. The article presents the results of a pilot study of the diversity and metabolic potential of the gut microbiome in adolescents with normal body weight and obesity. Biological material was studied using metagenomic sequencing of the V3-V4 variable regions of the 16S rRNA gene.

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Article Synopsis
  • The article discusses a pilot study examining the gut microbiome diversity and metabolic potential in adolescents with functional bowel disorders compared to healthy individuals.
  • Using advanced metagenomic sequencing techniques, researchers found distinct differences in the gut microbiome's composition between those with functional bowel disorders and the control group.
  • The study also revealed that adolescents could be classified into two groups based on their metabolic potential, indicating variations in amino acid and lipid biosynthesis metabolism regardless of their specific bowel disorder symptoms.
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Functional gastrointestinal disorders (FGIDs) in children and adolescents are one of the most common pathologies of the digestive tract. The aim of the study was to study the structure of the colon microbiota in obese adolescents and to establish its relationship with the clinical manifestations of the disease FGIDs. The study included 20 adolescents aged 11-17 years.

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Aim: To evaluate whether the health-related quality-of-life (HRQoL) scores would be different for adolescents with menstrual problems as compared to those with normal menstruation after taking into account clinical, socio-demographic and life-style factors.

Methods: The Paediatric Quality of Life Inventory 4.0 scale was used to assess HRQoL in 126 schoolgirls of 16 ± 0.

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Opportunistic microorganisms in the gut biocenosis were studied in adolescents with normal body weight and obesity (patients consulted at the Clinical Department of Research Center of Family Health and Human Reproduction Problems). The biological material was studied by standard bacteriological methods, representatives of Enterobacteriaceae family were also characterized using metagenomic sequencing of V3-V4 variable regions of 16S gene rRNA. Gut microbiota of obese adolescents was unbalanced and was characterized by low levels of bifido- and lactoflora representatives, a spectrum of E.

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Aim: To establish significant associations between hypertension and the presence and severity of common oral diseases in adolescents.

Material And Methods: A cross-sectional study was conductedWith participation of 130 adolescents, from which 2 groups were formed, matched by sex and age (=65; 38 boys and 28 girls in each group). Inclusion criteria: age 10-17 years; hypertension for inclusion in the group of «cases» and a normal level of blood pressure for inclusion in the control group; informed voluntary consent to participate in the study.

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An aorto-oesophageal fistula is a rare but life-threatening pathological condition developing on the background of diseases of the aorta and oesophagus, as well as after surgical interventions on the aorta. The article deals with a clinical case report regarding management of a patient presenting with an aorto-oesophageal fistula resulting from a thoracic artery aneurysm. The main clinical manifestations of the diseases included dysphagia (due to oesophageal obstruction caused by thrombotic masses of the aneurysm) and the occurring gastrointestinal haemorrhage.

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Childhood obesity and its consequences are a significant public health problem worldwide. Gut microbiota has a potential role in the development of. In the current datasets, we present 16S rDNA amplicon metasequencing of the gut microbiome of adolescents with normal weight, obesity, and obesity with irritable bowel syndrome (IBS) carried out using the Illumine platform.

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The Aim: Of the study was to establish the relationship of hemodynamic parameters of periodontal tissues and lipid peroxidation products in adolescents with arterial hypertension (AH).

Methods: The study included 132 adolescents (average age 14.51±1.

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Gut microbiome of adolescents with obesity and different duration of breastfeeding was analyzed by metagenomic analysis of V3-V4 variable domains of the 16S rRNA gene. In subgroup with breastfeeding duration <3 months, intrapopulation structure of gut microbiome by alpha diversity indices was similar in adolescents with obesity and normal body weight. The decrease in phylotype abundance in the structure of communities was associated only with obesity, while dysbiotic state persisted in both lean and overweight adolescents, which confirmed the effect of breastfeeding duration on stability of gut microbiome.

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Background: To-day, obesity spreads dramatically fast all over the world not only among the adults but also among the children. According to the data available from the scientific literature, the number of adolescents suffering from obesity in Russia increased more than 1.5 times during the period from 2006 till 2015.

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Aim: The objective of the present study was the improvement of the effectiveness of medical rehabilitation of the children presenting with the disturbances of the locomotor function using a «LymphaVision» apparatus for the selective electrical stimulation.

Materials And Methods: The study included 42 patients with movement disorders divided into two groups depending on the method of non-drug therapy. The main group was comprised of the patients receiving the treatment by electrical stimulation with the use of the «LymphaVision» apparatus while the remaining patients made up the group of comparison (they were treated with by means of Vermel electrophoresis with the use of a 1% sodium bromide solution).

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Background: A number of research studies have demonstrated a decrease in health-related quality of life (HRQL) measures among obese children. Moreover, the causes of HRQL impairments are not completely clear. Adolescent obesity is oftentimes associated with other cardiometabolic risk factors (CRFs); hence, the aim of our research was to estimate the frequency of CRFs and to determine whether there is an association between CRFs and HRQL scores among obese adolescents.

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Aim: To define the risk factors of complications which are followed by re-operations in patients with cardiac and pericardial wounds and to prevent these complications.

Material And Methods: Retrospective and prospective analysis of 1072 victims with cardiac and pericardial injuries for 35 years was performed. Overall mortality was 17.

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Multicentric carpotarsal osteolysis (MCTO) syndrome is a rare skeletal dysplasia associated with missense mutation in the MAFB gene, usually manifesting in young childhood, and showing variative phenotypic signs and course. The clinical manifestations of the syndrome include aggressive osteolysis predominantly of carpal and tarsal bones, progressive nephropathy, and mild craniofacial anomalies. The similarity between the initial clinical manifestations of MCTO and the symptoms of childhood inflammatory joint diseases makes a diagnosis very difficult, in the early stages of the disease in particular, and frequently leads to the ungrounded use of long-term immunosuppressive therapy.

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The results of the diagnosis and treatment of 117 patients with cervicothoracic injuries were analyzed. Different complications were observed in 51 (43.6%) cases.

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Aim: To elucidate links of blood serum uric acid level (SUAL) with cardiometabolic risk factors (CMR) in adolescent boys with arterial hypertension (AH).

Material And Methods: We examined 261 adolescent boys (mean age 15.8+/-1.

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It analyzed the diagnosis and treatment results of 123 patients with cervicothoracic injuries for 21 years. The frequency of cervicothoracic injuries among all patients with cervical injuries was 5.7%.

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The comparative analysis of 56 immunograms of patients with mediastinitis, caused by the esophagus trauma is represented. The mean values of 9 immunologic parameteres (the so called "norm of the pathology") were set for patients with noncomplicated mediastinitis. A novel method of the immune status evaluation for the patients with the acute surgical conditions and SIRS has been suggested.

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Treatment results of 38 cases of septic mediastinitis for the last 17 years were analyzed. The frequency of mediastinitis as a complication of the penetrating wound was 0.28%, and of the closed thoracic trauma - 0.

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