Irreversible electroporation in locally advanced pancreatic cancer.

Objective: To determine the feasibility of irreversible electroporation (IRE) for locally advanced pancreatic adenocarcinoma.

Material And Methods: Twenty-three patients underwent IRE after chemotherapy for locally advanced pancreatic cancer between 2015 and 2022. IRE was performed during laparotomy as a rule (=22).

[The role of molecular genetic factors in the development of cholangiocellular carcinoma].

The article lists the main inducers of cholangiocarcinogenesis. The main inflammatory mediators (IL-6, nitric oxide, COX2) have been considered. Data on the study of gene mutations in cholangiocarcinomas are presented.

[Cholangiocellular cancer: the state of the problem and ways to improve the results of surgical treatment].

Aim: To improve the outcomes in patients with resectable biliary cancer.

Material And Methods: There were 263 procedures for cholangiocellular carcinoma (CCC) for the period 1998—2017. Adjuvant chemotherapy was performed in 102 (38.

[Results of the repeated hepatic surgery on the reason of malignant tumors].

The work is based on an analysis of 95 clinical observations of patients with primary and metastatic liver disease who were in the surgical department of tumors of the liver and pancreas of the State Research Institute named by N.N. Blokhin of RAMS from 1990 to 2011.

[The possibilities of surgical treatment of hepatocellular cancer in patients with liver cirrhosis].

154 radical liver resections were performed on the reason of the hepatocellular cancer, of them 33% in patients with liver cirrhosis. Liver function was assessed using the Child--Pugh score. Liver cirrhosis and extensive liver resections proved to be the independent complication and lethality risk factors.

[Surgical treatment of hepatocellular carcinoma].

Experience of surgical treatment of 171 patients, suffering hepatocellular carcinoma (HCC), was summarized. Extensive hepatic operations were performed in 99 (71.2%) patients, of them in 22.

[The prognostic value of tumor cells blood circulation after liver surgery for cancer lesions].

The study aimed to prove the prognostic meaning of micrometastases blood circulation during liver resections for cancer lesions. 33 patients took part in the study. Circulating micrometastases were detected in blood using immunocytological method with pancytoceratine antibodies KL-1 and CAM 5.

[Surgical and combined treatment of multiple and bilobar metastatic affection of the liver].

Short- and long-term results of surgical treatment in combination with local exposures (cryo- and thermo-destruction) and adjuvant chemotherapy in patients treated for multiple and bilobar metastatic affection of the liver were studied. Postoperative lethality was 2,5% (n=2) due to liver insufficiency. Specific for liver resection complications (bile outflow, moderate hepatic failure) do not exceed 20,5%.

[Liver resection in locally-spread and metastatic kidney cancer].

The postoperative outcome and survival were studied in patients operated for renal cancer with involvement of the liver. 9 patients have undergone radical nephrectomy and 12 patients--hepatic resections for direct hepatic involvement (2), synchronous (2) and metachronous (8) metastases of renal cell carcinoma. Right hemihepatectomy was performed in 2 and wedge resection in 10 cases.

[Hepatopancreatoduodenal resection in locally advanced cancer of gallbladder].

A case of hepatopancreatoduodenectomy in advanced cancer of the gall bladder is presented as well as literature data on indications for this operation, technical peculiarities of its performance, postoperative complications, follow up results and advisability of carrying out such a complicated surgical intervention.