Publications by authors named "Podlasek A"

In recent years, civil engineering has increasingly embraced communication tools for automation, with sensors playing a pivotal role, especially in structural health monitoring (SHM). These sensors enable precise data acquisition, measuring parameters like force, displacement, and temperature and transmit data for timely interventions to prevent failures. This approach reduces reliance on manual inspections, offering more accurate outcomes.

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  • The ProFATE trial investigated the impact of temporary blood flow arrest during endovascular thrombectomy on vessel recanalization in patients with acute ischemic stroke.
  • Conducted across four UK centers, the study randomly assigned 134 adults to either a flow arrest or nonflow arrest group to assess the effectiveness of the procedure.
  • Results showed a slight increase in vessel recanalization in the flow arrest group (74.4%) compared to the nonflow arrest group (70.8%), suggesting a potential benefit of temporary blood flow arrest during treatment.
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  • Professor Klaus Fassbender is a prominent German neurologist known for his significant contributions to understanding neurodegenerative diseases like Alzheimer's and Parkinson's, as well as for improving treatment strategies.
  • His research has also advanced knowledge in cerebrovascular diseases, particularly in stroke mechanisms, leading to innovative therapeutic methods that apply lab discoveries in real-world clinical situations.
  • He pioneered the mobile stroke unit (MSU) concept, which allows for immediate prehospital stroke diagnosis and treatment, significantly improving patient outcomes by ensuring timely medical intervention.
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  • - The pre-frontal cortex is crucial for emotional, cognitive, and behavioral functions, and understanding lesions in this area is essential for proper diagnosis and treatment.
  • - The systematic review identified a strong link between right-handedness and cognition impairment due to prefrontal cortex lesions, with executive dysfunction being the most common symptom, followed by emotional instability and aphasia.
  • - Noninvasive brain stimulation is highlighted as an effective treatment for disorders related to prefrontal cortex lesions, but more research is needed to explore the relationship between handedness and lesion occurrence.
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Background: The efficacy and safety of endovascular thrombectomy (EVT) beyond 6 hours from stroke onset for patients with large vessel occlusion (LVO) selected without CT perfusion(CTP) or MR imaging(MRI) is undetermined. We conducted a systematic review and meta-analysis of the current literature comparing outcomes for late presenting patients with LVO treated by best medical management (BMM) with those selected for EVT based only on non-contrast CT(NCCT)/CT angiography(CTA) (without CTP or MRI).

Methods: PRISMA guidelines were employed.

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  • Congenital anomalies of coronary artery anatomy (CAAs) are often asymptomatic but can lead to serious health issues like arrhythmias and heart attacks, with a prevalence of 0.3% to 1.3% in the general population.
  • Multidetector computed tomography angiography (CTA) is an essential, non-invasive tool that improves the diagnosis and management of CAAs by providing better visualization.
  • This study, analyzing 756 coronary CTA examinations, identified 37 cases of CAAs and highlighted various anomalies, emphasizing the need for further research to improve understanding and patient care in this area.
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Urgent direct access to diagnostic services for general practitioners (GPs) is a new pathway to capture any cancer diagnoses that may have been missed due to vague symptom presentations. Hence, GPs should look out for the key symptoms mentioned by NHS England that should prompt urgent direct access referrals for chest X-ray (CXR), computed tomography (CT) chest, MRI brain, ultrasound (US) abdomen and pelvis, and CT abdomen and pelvis. By implementing this approach, we can significantly reduce the time to diagnosis, while minimizing the number of visits to GP and specialist appointments prior to initiating investigations.

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Background: Carotid-related strokes (CRS) are largely unresponsive to intravenous thrombolysis and are often large and disabling. Little is known about contemporary CRS referral pathways and proportion of eligible patients who receive emergency mechanical reperfusion (EMR).

Methods: Referral pathways, serial imaging, treatment data, and neurologic outcomes were evaluated in consecutive CRS patients presenting over 18 months in catchment area of a major carotid disease referral center with proximal-protected CAS expertise, on-site neurology, and stroke thrombectomy capability (Acute Stroke of CArotid Artery Bifurcation Origin Treated With Use oF the MicronEt-covered CGUARD Stent - SAFEGUARD-STROKE Registry; companion to SAFEGUARD-STROKE Study NCT05195658).

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The aim of this study was to evaluate the mobility of copper (Cu) and zinc (Zn) and their impact on the properties of bentonites and unfrozen water content. Limited research in this area necessitates further analysis to prevent the negative effects of metal interactions on bentonite effectiveness. Tests involved American (SWy-3, Stx-1b) and Slovak (BSvk) bentonite samples with Zn or Cu ion exchange.

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This study presents an analysis of soil contamination caused by Ni, Zn, Cd, Cu, and Pb at municipal solid waste (MSW) landfills, with a focus on ecological risk assessment. The approach aims to assess how different landfill practices and environmental conditions affect soil contamination with potentially toxic elements (PTEs) and associated environmental risks. Soil samples were collected from MSW landfills in Poland and the Czech Republic.

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This study investigates human health risks associated with heavy metals (HMs) occurrence in municipal solid waste (MSW) landfills. For testing of selected MSW landfills steps were involved, including site characterization, soil sampling and chemical testing, statistical analysis, as well as health risk assessment, carcinogenic and non-carcinogenic effects. For the Polish landfill (Radiowo) the average HMs concentrations were found in the following order: Zn (52.

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  • A recent study evaluated the effectiveness of second-generation carotid stents (SGS) compared to traditional single-layer stents and carotid endarterectomy (CEA), finding that SGS can lead to better outcomes in certain cases.
  • Data from over 100,000 patients indicated that specific SGS designs, like Casper/Roadsaver and CGuard, significantly reduced the risk of death, stroke, and myocardial infarction compared to CEA, while Gore stent outcomes were generally poorer.
  • Overall, the findings suggest that certain SGS types may offer advantages over CEA, but the performance varies by stent design, highlighting the need for cautious interpretation and consideration of individual patient circumstances.
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Introduction: Perianal fistulas demand precise preoperative assessment for optimal surgical outcomes. MRI, using Short Tau Inversion Recovery (STIR) and T1-post contrast sequences, plays a crucial role in this evaluation.This retrospective cohort study compared STIR imaging's diagnostic efficacy with T1-post contrast sequences in identifying perianal fistulous tracts.

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Background: Half of patients who achieve successful recanalization following endovascular thrombectomy (EVT) for acute ischemic stroke experience poor functional outcome. We aim to investigate whether the use of adjunctive intra-arterial antithrombotic therapy (AAT) during EVT is safe and efficacious compared with standard therapy (ST) of EVT with or without prior intravenous thrombolysis.

Methods: Electronic databases were searched (PubMed/MEDLINE, Embase, Cochrane Library) from 2010 until October 2023.

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Unlabelled: Our study aimed to assess the feasibility outcomes comparing spinal medial branch nerve root block intervention to standard care vertebroplasty for the treatment of painful osteoporotic vertebral fractures in frail, hospitalised older patients. We found the study to be feasible and now propose a clinical effectiveness, cost effectiveness and safety evaluation.

Introduction: Vertebroplasty (VP) is a key-hole procedure involving injection of bone cement into a fractured vertebral body, to reduce pain and increase vertebral body stability, although it is associated with a small risk of complications, particularly in frail, older hospitalised patients.

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Purpose: To evaluate endovascular popliteal artery aneurysm repair using a an "off-label" abdominal endograft limb-module with nitinol-ring structure.

Materials And Methods: Retrospective observational study of 14 popliteal artery aneurysms in 12 male patients (mean age 76 years and median ASA grade 3) treated electively using the Anaconda™ endograft limb (Terumo Aortic) at a single teaching hospital. Eight limbs were treated percutaneously and 6 limbs required surgical arterial exposure.

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Carotid atherosclerotic disease continues to be an important cause of stroke, often disabling or fatal. Such strokes could be largely prevented through optimal medical therapy and carotid revascularization. Advancements in discovery research and imaging along with evidence from recent pharmacology and interventional clinical trials and registries and the progress in acute stroke management have markedly expanded knowledge base for clinical decisions in carotid stenosis.

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The aim of this review is to provide an overview of the use of antiplatelet medication in neurointervention, with a focus on the clinical indications for antiplatelet use in both preventing and reducing platelet aggregation. This review will cover current antiplatelet medications, pharmacokinetics, and pharmacodynamics. We will provide an overview of different endovascular devices and discuss the antiplatelet regimes in neurointervention, highlighting gaps in evidence and scope for future studies.

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Hepatocellular carcinoma (HCC) is responsible for 90% of primary hepatic cancer cases, and its incidence with associated morbidity and mortality is growing worldwide. In recent decades, there has been a revolution in HCC treatment. There are three main types of locoregional therapy: radiofrequency ablation, transarterial chemoembolisation, and transarterial radioembolisation.

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Aims: To determine effects of concurrent smoking and nicotine replacement therapy (NRT) use on reported heaviness of smoking, nicotine (cotinine) body fluid and exhaled air carbon monoxide (CO) concentrations.

Methods: Systematic review and meta-analysis of RCTs, which test interventions permitting concurrent NRT use and smoking and comparing, within participants, outcomes when smoking with those when smoking and using NRT concurrently. Measurements included reported number of cigarettes smoked per day (CPD), body fluid cotinine and expired air CO concentrations.

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The implementation of circular economy (CE) strategies has facilitated a comprehensive approach to waste management (WM) in university campuses. Composting food waste (FW) and biomass can mitigate negative environmental impacts and be part of a closed-loop economy. The compost can be used as a fertilizer, thereby closing the waste cycle.

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Background: Observational studies have demonstrated improved outcomes with the adjunctive use of balloon guide catheters (BGC) during endovascular thrombectomy (EVT) for anterior circulation acute ischaemic stroke (AIS). However, the lack of high-level evidence and global practice heterogeneity justifies a randomised controlled trial (RCT) to investigate the effect of transient proximal blood flow arrest on the procedural and clinical outcomes of patients with AIS following EVT.

Hypothesis: Proximal blood flow arrest in the cervical internal carotid artery during EVT for proximal large vessel occlusion is superior to no flow arrest in achieving complete vessel recanalisation.

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  • Endovascular treatment (EVT) is essential for strokes caused by large vessel occlusion, but a shortage of trained physicians and centers limits patient access to this crucial therapy, leading to delays in treatment.
  • The World Federation for Interventional Stroke Treatment (WIST) proposes competency-based training guidelines to ensure proper accreditation and certification of medical professionals and facilities involved in EVT.
  • WIST emphasizes a personalized training approach that incorporates innovative methods like high-fidelity simulations and human cadaveric models to improve the proficiency of interventionalists and enhance the quality of stroke care.
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