A Revised Abaqus Procedure for Fracture Path Simulation Based on the Material Effort Criterion.

This paper presents the results of computer simulations of fracture in three laboratory tests: the three-point bending of a notched beam cut from sandstone, the pull-out test of a self-undercutting anchor fixed in sandstone, and the pull-out test of a bar embedded in concrete. Five material failure criteria were used: Rankine, Coulomb-Mohr, Drucker-Prager, Ottosen-Podgórski, and Hoek-Brown. These criteria were implemented in the Abaqus FEA system to work with the crack propagation modeling method-extended finite element method (X-FEM).

Geochemical insights of arsenic mobilization into the aquifers of Punjab, Pakistan.

It is well known that groundwater arsenic (As) contamination affects million(s) of people throughout the Indus flood plain, Pakistan. In this study, groundwater (n = 96) and drilled borehole samples (n = 87 sediments of 12 boreholes) were collected to investigate geochemical proxy-indicators for As release into groundwater across floodplains of the Indus Basin. The mean dissolved (μg/L) and sedimentary As concentrations (mg/kg) showed significant association in all studied areas viz.

Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation.

Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous remodeling of the ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controlled by extracellular signals remains unknown. Here we report that TAK1, a kinase responsive to various growth factors and cytokines including TGF-β and TNF-α, triggers ER tubulation by activating αTAT1, an MT-acetylating enzyme that enhances ER-sliding.

Phosphoproteomic profiling identifies DNMT1 as a key substrate of beta IV spectrin-dependent ERK/MAPK signaling in suppressing angiogenesis.

βIV-spectrin is a membrane-associated cytoskeletal protein that maintains the structural stability of cell membranes and integral proteins such as ion channels and transporters. Its biological functions are best characterized in the brain and heart, although recently we discovered a fundamental new role in the vascular system. Using cellular and genetic mouse models, we reported that βIV-spectrin acts as a critical regulator of developmental and tumor-associated angiogenesis.

A novel stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids.

Tailed bacteriophages are one of the most numerous and diverse group of viruses. They store their genome at quasi-crystalline densities in capsids built from multiple copies of proteins adopting the HK97-fold. The high density of the genome exerts an internal pressure, requiring a maturation process that reinforces their capsids.

Evaluating the impact of the Central Chile Mega Drought on debris cover, broadband albedo, and surface drainage system of a Dry Andes glacier.

In recent years, Chile has experienced an extraordinary drought that has had significant impacts on both the livelihoods of people and the environment, including the Andean glaciers. This study focuses on analyzing the surface processes of Universidad Glacier, a benchmark glacier for the Dry Andes. Multiple remote sensing datasets are used alongside a novel spectral index designed for mapping of rock material located on the glacier's surface.

Virion glycosylation influences mycobacteriophage immune recognition.

Glycosylation of eukaryotic virus particles is common and influences their uptake, trafficking, and immune recognition. In contrast, glycosylation of bacteriophage particles has not been reported; phage virions typically do not enter the cytoplasm upon infection, and they do not generally inhabit eukaryotic systems. We show here that several genomically distinct phages of Mycobacteria are modified with glycans attached to the C terminus of capsid and tail tube protein subunits.

Solution for Determining Modulus of Elasticity of Natural Materials Using Vibrations of Non-Uniform Circular Cross-Section Cantilevers.

The article presents an original method for determining the modulus of elasticity of natural materials. A studied solution was based on vibrations of non-uniform circular cross-section cantilevers solved using Bessel functions. The derived equations, together with experimental tests, allowed for calculating the material's properties.

Groundwater salinity in the Horn of Africa: Spatial prediction modeling and estimated people at risk.

Background: Changes in climate and anthropogenic activities have made water salinization a significant threat worldwide, affecting biodiversity, crop productivity and contributing to water insecurity. The Horn of Africa, which includes eastern Ethiopia, northeast Kenya, Eritrea, Djibouti, and Somalia, has natural characteristics that favor high groundwater salinity. Excess salinity has been linked to infrastructure and health problems, including increased infant mortality.

Gaseous and soil OCPs and PCBs along the Indus River, Pakistan: spatial patterns and air-soil gradients.

This study presents first-hand information on the occurrence of persistent organic pollutants (POPs) in the ambient air and surface soil along the Indus flood-plain, Pakistan. The sampling campaign was conducted at 15 site locations during 2014-15, along the Indus River (approximately 1300 km). Composite surface soil samples ( = 15) and passive air samples ( = 15) were collected for the estimation of gaseous POPs as well as air-soil exchange to evaluate the POP emission and distribution or dispersion patterns, source tracking, and contribution of the local and regional sources towards POP accumulation in the Indus River system.

A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability.

Many double-stranded DNA viruses, including tailed bacteriophages (phages) and herpesviruses, use the HK97-fold in their major capsid protein to make the capsomers of the icosahedral viral capsid. After the genome packaging at near-crystalline densities, the capsid is subjected to a major expansion and stabilization step that allows it to withstand environmental stresses and internal high pressure. Several different mechanisms for stabilizing the capsid have been structurally characterized, but how these mechanisms have evolved is still not understood.

Global analysis and prediction of fluoride in groundwater.

The health of millions of people worldwide is negatively impacted by chronic exposure to elevated concentrations of geogenic fluoride in groundwater. Due to health effects including dental mottling and skeletal fluorosis, the World Health Organization maintains a maximum guideline of 1.5 mg/L in drinking water.

Monitoring and prediction of high fluoride concentrations in groundwater in Pakistan.

Concentrations of naturally occurring fluoride in groundwater exceeding the WHO guideline of 1.5 mg/L have been detected in many parts of Pakistan. This may lead to dental or skeletal fluorosis and thereby poses a potential threat to public health.

Freely dissolved organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) along the Indus River Pakistan: spatial pattern and risk assessment.

Freely dissolved OCPs and PCBs were measured by using polyethylene passive samplers at 15 sites during 2014 throughout the stretch of the Indus River to investigate the spatial pattern and risk assess. Levels (pg/L) of dissolved ∑OCPs and ∑PCBs ranged from 34 to 1600 and from 3 to 230. Among the detected OCPs, dissolved DDTs (p,p'-DDE, followed by p,p'-DDT) predominated with levels of 0.

Geogenic manganese and iron in groundwater of Southeast Asia and Bangladesh - Machine learning spatial prediction modeling and comparison with arsenic.

Naturally occurring, geogenic manganese (Mn) and iron (Fe) are frequently found dissolved in groundwater at concentrations that make the water difficult to use (deposits, unpleasant taste) or, in the case of Mn, a potential health hazard. Over 6000 groundwater measurements of Mn and Fe in Southeast Asia and Bangladesh were assembled and statistically examined with other physicochemical parameters. The machine learning methods random forest and generalized boosted regression modeling were used with spatially continuous environmental parameters (climate, geology, soil, topography) to model and map the probability of groundwater Mn > 400 μg/L and Fe > 0.

Chromium contamination in paddy soil-rice systems and associated human health risks in Pakistan.

Chromium (Cr) contamination in paddy soil-rice systems threatens human health through the food chain. This study used a new dataset of 500 paddy soil and plant tissue samples collected in the rice-growing regions of Sindh and Punjab Provinces of Pakistan. Overall, 97.

Fluoride contamination of groundwater resources in Ghana: Country-wide hazard modeling and estimated population at risk.

Most people in Ghana have no or only basic access to safely managed water. Especially in rural areas, much of the population relies on groundwater for drinking, which can be contaminated with fluoride and lead to dental fluorosis. Children under the age of two are particularly susceptible to the adverse effects of fluoride and can retain 80-90% of a fluoride dose, compared to 60% in adults.

Comparison of Various Criteria Determining the Direction of Crack Propagation Using the UDMGINI User Procedure Implemented in Abaqus.

This paper describes a method of predicting the direction of crack propagation implemented by user subroutines in the Simulia-Abaqus FEA system with the use of the extended finite element method (X-FEM). This method is based on displacements and stresses according to Westergaard's solution of Griffith's crack problem. During the calculations, in each crack increment, the algorithm reads the stresses and displacements in the model around the crack tip, calculates the criterion values at the read points, reduces them to a unit distance from the crack tip, fits a polynomial to these points, and finds the minimum of the function closest to the last propagation angle.

Extended Hückel Semi-Empirical Approach as an Efficient Method for Structural Defects Analysis in 4H-SiC.

This paper presents an efficient method to calculate the influence of structural defects on the energy levels and energy band-gap for the 4H-SiC semiconductor. The semi-empirical extended Hückel method was applied to both ideal 4H-SiC crystal and different structures with defects like vacancies, stacking faults, and threading edge dislocations. The Synopsys QuatumATK package was used to perform the simulations.

The Effect of Glue Cohesive Stiffness on the Elastic Performance of Bent Wood-CFRP Beams.

This paper presents experimental, theoretical and numerical studies of wood-CFRP beams bonded with polyurethane (PUR) adhesive. The analyses include two types of CFRP (carbon fibre-reinforced polymer) strengthening configurations and pure glue laminated timber beams as a reference. Through detailed analyses of a double-lap connection on blocks with and without CFRP strips, the authors state that neglecting the cohesive stiffness of adhesive layers may lead to an overestimation of an overall beam's stiffness.

Groundwater Arsenic Distribution in India by Machine Learning Geospatial Modeling.

Groundwater is a critical resource in India for the supply of drinking water and for irrigation. Its usage is limited not only by its quantity but also by its quality. Among the most important contaminants of groundwater in India is arsenic, which naturally accumulates in some aquifers.

Geostatistical model of the spatial distribution of arsenic in groundwaters in Gujarat State, India.

Geogenic arsenic contamination in groundwaters poses a severe health risk to hundreds of millions of people globally. Notwithstanding the particular risks to exposed populations in the Indian sub-continent, at the time of writing, there was a paucity of geostatistically based models of the spatial distribution of groundwater hazard in India. In this study, we used logistic regression models of secondary groundwater arsenic data with research-informed secondary soil, climate and topographic variables as principal predictors generate hazard and risk maps of groundwater arsenic at a resolution of 1 km across Gujarat State.

Global threat of arsenic in groundwater.

Naturally occurring arsenic in groundwater affects millions of people worldwide. We created a global prediction map of groundwater arsenic exceeding 10 micrograms per liter using a random forest machine-learning model based on 11 geospatial environmental parameters and more than 50,000 aggregated data points of measured groundwater arsenic concentration. Our global prediction map includes known arsenic-affected areas and previously undocumented areas of concern.